glycogen synthase kinase 3 alpha

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Synonym

Glycogen synthase kinase-3 alpha, GSK3A, glycogen synthase kinase 3 alpha, GSK-3 alpha, DKFZp686D0638

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:73.50 cerebellum:50.40 brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:122.70 spine:112.30 retina:- eye:170.40 artery/aorta:- vein:66.60 lymphnode:121.30 peripheral blood:18.20 spleen:94.50 thymus:25.80 bone marrow:118.10 adipose:- bone:25.60 skin:62.40
GeneChip cerebrum:6.72 cerebellum:6.68 brain stem:6.71 corpus callosum/glia:6.50 pineal gland:- peripheral nerve:6.64 spine:6.60 retina:- eye:- artery/aorta:6.79 vein:6.64 lymphnode:6.49 peripheral blood:- spleen:6.36 thymus:6.34 bone marrow:6.75 adipose:6.64 bone:- skin:6.52
CAGE cerebrum:4.20 cerebellum:- brain stem:4.13 corpus callosum/glia:4.22 pineal gland:3.67 peripheral nerve:- spine:3.58 retina:- eye:- artery/aorta:3.58 vein:3.59 lymphnode:3.38 peripheral blood:- spleen:3.48 thymus:3.61 bone marrow:- adipose:3.26 bone:- skin:-
RNA-seq cerebrum:4.81 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:4.68 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.79 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:45.60 placenta:87.40 prostate:56.30 ovary:74.50 testis:51.90 heart:63.90 muscle:20.10 esophagus:- stomach:42.50 intestine:64.80 colon:288.30     liver/hepato:-        lung:63.50    bladder:125.60 kidney:187.10 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:71.10 breast:83.60 salivary:328.40
GeneChip uterus:6.49 placenta:6.57 prostate:6.37 ovary:6.32 testis:6.62 heart:6.52 muscle:6.59 esophagus:6.64 stomach:6.54 intestine:6.82 colon:6.68 liver/hepato:6.57 lung:6.44 bladder:- kidney:6.53 pituitary:6.93 thyroid/parathyroid:6.53 adrenal gland:6.54 pancreas:7.35 breast:6.36 salivary:6.30
CAGE uterus:3.47 placenta:3.61 prostate:3.67 ovary:3.49 testis:3.95 heart:3.51 muscle:3.59 esophagus:3.58 stomach:- intestine:4.13 colon:3.72     liver/hepato:3.39    lung:3.46 bladder:3.45 kidney:3.67 pituitary:3.19 thyroid/parathyroid:3.71 adrenal gland:- pancreas:3.34 breast:3.60 salivary:3.42
RNA-seq uterus:- placenta:- prostate:4.87 ovary:3.93 testis:4.67 heart:3.82 muscle:5.35 esophagus:- stomach:- intestine:- colon:4.10     liver/hepato:3.52        lung:4.55    bladder:- kidney:4.14 pituitary:- thyroid/parathyroid:4.23 adrenal gland:3.68 pancreas:- breast:3.66 salivary:-

Gene Information

IDs

Refseq ID NM_019884
Gene ID 2931
Unigene ID Hs.466828
Probe set ID 632_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000105723
GTEx ID ENSG00000105723

Orthologous Gene

Mouse[1]  NM_001031667
Rat[1]  NM_017344

Chromosomal Region

19q13.2  [42,734,338  -  42,746,777]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

7706316
7715701
7931292
8404858
8524413
8725894
9468292
9735171
9809441
10448973
11035810
11481324
11500362
11509608
11749387
11884598
12054501
12086949
12379450
12477932
12665592
12675919
12761548
12890758
14550568
14563837
14635195
14645548
15057824
15194499
15302935
15324660
15361837
15469820
15489334
15592455
15631989
15678105
16365045
16371461
16446437
16537926
16543145
16543730
16611631
16757548
16806170
16912034
16934436
16984735
16987514
17052453
17139249
17158447
17192257
17325032
17505062
17569761
17609434
18042454
18285345
18450971
18500637
18516299
18826950
18829575
18955053
19131971
19136008
19142874
19156168
19323791
19336475
19366350
19464003
19507191
19656851
19705135
19706605
19759537
19995607
20080974
20113358
20368287
20371704
20541704
20668436
20831597
20920357
21139048
21220517
21255011
21320285
21436692
21576335
21718540
21775285
21890473
21896753
22022450
22065737
22326953
22328534
22384031
22505724
22539113
22539723
22658458
22939624
23000965
23192081
23243017
23352529
23369789
23602568
23621307
23798682
23959799
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0006987  activation of signaling protein activity involved in unfolded protein response
GO:0003214  cardiac left ventricle morphogenesis
GO:0016477  cell migration
GO:0044267  cellular protein metabolic process
GO:0032869  cellular response to insulin stimulus
GO:0071285  cellular response to lithium ion
GO:0071407  cellular response to organic cyclic substance
GO:0030968  endoplasmic reticulum unfolded protein response
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0008543  fibroblast growth factor receptor signaling pathway
GO:0006349  genetic imprinting
GO:0005977  glycogen metabolic process
GO:0044027  hypermethylation of CpG island
GO:0045087  innate immune response
GO:0008286  insulin receptor signaling pathway
GO:0046325  negative regulation of glucose import
GO:0045719  negative regulation of glycogen biosynthetic process
GO:0046627  negative regulation of insulin receptor signaling pathway
GO:0032007  negative regulation of TOR signaling pathway
GO:0051348  negative regulation of transferase activity
GO:0010905  negative regulation of UDP-glucose catabolic process
GO:0090090  negative regulation of Wnt receptor signaling pathway through beta-catenin
GO:0048011  nerve growth factor receptor signaling pathway
GO:0007399  nervous system development
GO:0048015  phosphoinositide-mediated signaling
GO:0030819  positive regulation of cAMP biosynthetic process
GO:0045823  positive regulation of heart contraction
GO:0033138  positive regulation of peptidyl-serine phosphorylation
GO:0010800  positive regulation of peptidyl-threonine phosphorylation
GO:0045732  positive regulation of protein catabolic process
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0006468  protein amino acid phosphorylation
GO:0003073  regulation of systemic arterial blood pressure
GO:0016055  Wnt receptor signaling pathway

Cellular Component

GO:0030877  beta-catenin destruction complex
GO:0005829  cytosol

Molecular Function

GO:0005524  ATP binding
GO:0005515  protein binding
GO:0034236  protein kinase A catalytic subunit binding
GO:0004674  protein serine/threonine kinase activity
GO:0050321  tau-protein kinase activity