LAG1 homolog, ceramide synthase 2

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Synonym

SP260, MGC987, TMSG1, Tumor metastasis-suppressor gene 1 protein, LAG1 longevity assurance homolog 2, LASS2, FLJ10243, LAG1 homolog, ceramide synthase 2 (S. cerevisiae)

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:8.15 cerebellum:7.38 brain stem:8.51 corpus callosum/glia:9.56 pineal gland:- peripheral nerve:8.45 spine:9.35 retina:- eye:- artery/aorta:8.02 vein:8.09 lymphnode:7.97 peripheral blood:- spleen:8.14 thymus:7.61 bone marrow:8.21 adipose:8.17 bone:- skin:7.47
CAGE cerebrum:3.90 cerebellum:- brain stem:4.81 corpus callosum/glia:5.34 pineal gland:3.10 peripheral nerve:- spine:4.65 retina:- eye:- artery/aorta:4.28 vein:3.82 lymphnode:3.66 peripheral blood:- spleen:3.82 thymus:3.42 bone marrow:- adipose:4.23 bone:- skin:-
RNA-seq cerebrum:1.08 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.24 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.74 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:8.17 placenta:8.48 prostate:8.42 ovary:8.49 testis:7.64 heart:7.83 muscle:7.12 esophagus:7.59 stomach:8.44 intestine:8.17 colon:8.22 liver/hepato:10.35 lung:8.84 bladder:- kidney:9.65 pituitary:8.32 thyroid/parathyroid:9.10 adrenal gland:9.47 pancreas:8.45 breast:8.65 salivary:7.97
CAGE uterus:3.91 placenta:4.01 prostate:4.19 ovary:4.17 testis:3.79 heart:3.98 muscle:2.75 esophagus:3.79 stomach:- intestine:4.73 colon:4.16     liver/hepato:5.85    lung:4.69 bladder:4.01 kidney:5.31 pituitary:3.86 thyroid/parathyroid:4.64 adrenal gland:- pancreas:4.50 breast:4.41 salivary:3.60
RNA-seq uterus:- placenta:- prostate:0.84 ovary:1.30 testis:1.29 heart:0.44 muscle:0.00 esophagus:- stomach:- intestine:- colon:2.38     liver/hepato:1.03        lung:1.00    bladder:- kidney:3.14 pituitary:- thyroid/parathyroid:0.48 adrenal gland:0.95 pancreas:- breast:1.35 salivary:-

Gene Information

IDs

Refseq ID NM_181746
Gene ID 29956
Unigene ID -
Probe set ID 222212_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000143418
GTEx ID ENSG00000143418

Orthologous Gene

Mouse[1]  NM_029789
Rat [0]  

Chromosomal Region

1q21.3  [150,933,059  -  150,947,479]

Gene Family (Interpro ID)

IPR001356  Homeobox
IPR009057  Homeodomain-like
IPR012287  Homeodomain-related

Link to Pubmed  (Pubmed ID)

11543633
12477932
14702039
15489334
16263699
16341674
16344560
17081983
17353931
18029348
18165233
18194600
19728861
19912991
19946888
20195357
20383146
20406683
20937905
21139048
21755371
21890473
21906983
21928351
21988832
22169644
22178826
22190034
22336162
22573553
22580606
22939629
22991218
23000965
23538298
23585552
23690971
24097068

Gene Ontology  (GO ID)

Biological Process

GO:0046513  ceramide biosynthetic process
GO:0030148  sphingolipid biosynthetic process
GO:0006665  sphingolipid metabolic process

Cellular Component

GO:0005783  endoplasmic reticulum
GO:0005789  endoplasmic reticulum membrane
GO:0016021  integral to membrane
GO:0031965  nuclear membrane

Molecular Function

GO:0005515  protein binding
GO:0043565  sequence-specific DNA binding
GO:0050291  sphingosine N-acyltransferase activity
GO:0003700  transcription factor activity