granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)

Synonym

T-cell serine protease 1-3E, CCPI, Human lymphocyte protein, Granzyme-2, Fragmentin-2, Granzyme B precursor, CGL1, GZMB, CTSGL1, GRB, CGL-1, CSP-B, CTLA1, CTLA-1, Cathepsin G-like 1, CSPB, SECT, Cytotoxic T-lymphocyte proteinase 2, Lymphocyte protease

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:58.10

cerebellum:201.50

brain stem:-

corpus callosum/glia:29.20

pineal gland:-

peripheral nerve:-

spine:224.60

retina:237.30

eye:47

artery/aorta:89.90

vein:-

lymphnode:182

peripheral blood:36.40

spleen:37.80

thymus:25.80

bone marrow:39.40

adipose:80.70

bone:12.80

skin:28.80

GeneChip

cerebrum:3.46

cerebellum:3.46

brain stem:3.48

corpus callosum/glia:3.38

pineal gland:-

peripheral nerve:3.53

spine:3.49

retina:-

eye:-

artery/aorta:3.80

vein:3.80

lymphnode:4.34

peripheral blood:-

spleen:6.17

thymus:3.79

bone marrow:4.58

adipose:4.13

bone:-

skin:4.22

CAGE

cerebrum:0.23

cerebellum:-

brain stem:0.37

corpus callosum/glia:0.34

pineal gland:0.36

peripheral nerve:-

spine:0.42

retina:-

eye:-

artery/aorta:1.65

vein:3.06

lymphnode:1.79

peripheral blood:-

spleen:3.45

thymus:1.85

bone marrow:-

adipose:1.97

bone:-

skin:-

RNA-seq

cerebrum:0.08

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:2.13

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:1.46

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:27.30

placenta:58.30

prostate:33.80

ovary:37.30

testis:26

heart:25.50

muscle:80.40

esophagus:-

stomach:42.50

intestine:-

colon:101.80

liver/hepato:52.80

lung:19.60

bladder:125.60

kidney:62.40

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:62.20

breast:9.30

salivary:-

GeneChip

uterus:3.89

placenta:3.55

prostate:3.52

ovary:3.40

testis:3.33

heart:3.61

muscle:3.74

esophagus:3.64

stomach:3.79

intestine:3.55

colon:3.77

liver/hepato:3.85

lung:5.47

bladder:-

kidney:3.47

pituitary:3.51

thyroid/parathyroid:3.41

adrenal gland:3.49

pancreas:3.47

breast:3.46

salivary:3.41

CAGE

uterus:1.28

placenta:2.04

prostate:1.32

ovary:0.86

testis:0.71

heart:1.22

muscle:0.99

esophagus:1.52

stomach:-

intestine:1.20

colon:0.67

liver/hepato:1.79

lung:3.14

bladder:0.83

kidney:1.06

pituitary:0.19

thyroid/parathyroid:1.55

adrenal gland:-

pancreas:0.58

breast:1.36

salivary:1.15

RNA-seq

uterus:-

placenta:-

prostate:1.19

ovary:0.66

testis:1.16

heart:0.65

muscle:0.23

esophagus:-

stomach:-

intestine:-

colon:0.52

liver/hepato:0.41

lung:3.87

bladder:-

kidney:0.65

pituitary:-

thyroid/parathyroid:0.11

adrenal gland:1.70

pancreas:-

breast:1.59

salivary:-

IDs

Refseq ID	NM_004131
Gene ID	3002
Unigene ID	Hs.105105
Probe set ID	210164_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000100453
GTEx ID	ENSG00000100453

Orthologous Gene

Mouse[9]	NM_013542, NM_010374, NM_153052, NM_010373, NM_010375, NM_010372, NM_010371
Rat [0]

Chromosomal Region

14q12 [25,100,160 - 25,103,473]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR001254	Peptidase S1/S6, chymotrypsin/Hap
IPR001314	Peptidase S1A, chymotrypsin
IPR009003	Serine/cysteine peptidase, trypsin-like

Gene Ontology (GO ID)

Biological Process

GO:0006915	apoptosis
GO:0006922	cleavage of lamin
GO:0019835	cytolysis
GO:0007219	Notch signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0001772	immunological synapse
GO:0043231	intracellular membrane-bounded organelle
GO:0005634	nucleus

Molecular Function

GO:0005515	protein binding
GO:0004252	serine-type endopeptidase activity
GO:0008236	serine-type peptidase activity

granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function