hematopoietic cell-specific Lyn substrate 1

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Synonym

Hematopoietic lineage cell-specific protein, HCLS1, hematopoietic cell-specific Lyn substrate 1, Hematopoietic cell-specific LYN substrate 1, LckBP1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:30.80 cerebellum:25.20 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:112.30 retina:- eye:76.40 artery/aorta:60 vein:- lymphnode:424.60 peripheral blood:382.60 spleen:586.10 thymus:335 bone marrow:157.40 adipose:80.70 bone:217.50 skin:134.40
GeneChip cerebrum:5.43 cerebellum:4.76 brain stem:5.63 corpus callosum/glia:6.54 pineal gland:- peripheral nerve:6.83 spine:6.91 retina:- eye:- artery/aorta:6.56 vein:5.92 lymphnode:9.24 peripheral blood:- spleen:9.67 thymus:9.25 bone marrow:9.55 adipose:7.03 bone:- skin:6.58
CAGE cerebrum:3.08 cerebellum:- brain stem:3.67 corpus callosum/glia:3.79 pineal gland:2.94 peripheral nerve:- spine:4.21 retina:- eye:- artery/aorta:3.44 vein:5.38 lymphnode:5.51 peripheral blood:- spleen:5.89 thymus:5.11 bone marrow:- adipose:4.82 bone:- skin:-
RNA-seq cerebrum:3.40 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:5.66 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:5.46 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:98.40 prostate:11.30 ovary:37.30 testis:8.70 heart:51.10 muscle:- esophagus:- stomach:85 intestine:194.40 colon:42.40     liver/hepato:52.80        lung:78.20    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:35.60 breast:- salivary:-
GeneChip uterus:6.06 placenta:7.29 prostate:5.86 ovary:5.92 testis:4.85 heart:5.96 muscle:4.81 esophagus:5.96 stomach:7.07 intestine:6.69 colon:6.57 liver/hepato:6.83 lung:8.17 bladder:- kidney:5.32 pituitary:6.07 thyroid/parathyroid:6.25 adrenal gland:6.68 pancreas:6.59 breast:6.43 salivary:5.59
CAGE uterus:3.43 placenta:4.25 prostate:3.31 ovary:3.23 testis:2.77 heart:3.62 muscle:3.37 esophagus:3.27 stomach:- intestine:3.65 colon:3.42     liver/hepato:3.70    lung:4.37 bladder:3.63 kidney:3.91 pituitary:3.62 thyroid/parathyroid:2.96 adrenal gland:- pancreas:2.48 breast:3.19 salivary:3.58
RNA-seq uterus:- placenta:- prostate:3.13 ovary:3.13 testis:2.81 heart:3.07 muscle:1.01 esophagus:- stomach:- intestine:- colon:3.16     liver/hepato:3.90        lung:4.36    bladder:- kidney:4.06 pituitary:- thyroid/parathyroid:3.23 adrenal gland:6.13 pancreas:- breast:3.81 salivary:-

Gene Information

IDs

Refseq ID NM_005335
Gene ID 3059
Unigene ID Hs.14601
Probe set ID 202957_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000180353
GTEx ID ENSG00000180353

Orthologous Gene

Mouse[1]  NM_008225
Rat[1]  NM_001011898

Chromosomal Region

3q13.33  [121,350,246  -  121,379,774]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

2587259
7682714
7927516
8125298
8713105
8978766
9058808
9104825
9670936
10066823
10233887
10590261
10806407
11689006
11988074
12477932
12522270
12534372
14702039
15022330
15144186
15166239
15489334
15570572
15710041
15754022
15795233
16094384
16157603
16189514
16713569
17508001
18029348
18067320
20211142
20467438
20530793
21044950
21287358
22333038
22679023
22768161
23001182
23017497
23022380
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0071345  cellular response to cytokine stimulus
GO:0030218  erythrocyte differentiation
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0008284  positive regulation of cell proliferation
GO:0030854  positive regulation of granulocyte differentiation
GO:0045651  positive regulation of macrophage differentiation
GO:0033138  positive regulation of peptidyl-serine phosphorylation
GO:0050731  positive regulation of peptidyl-tyrosine phosphorylation
GO:0014068  positive regulation of phosphoinositide 3-kinase cascade
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0042993  positive regulation of transcription factor import into nucleus
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0042531  positive regulation of tyrosine phosphorylation of STAT protein
GO:0030833  regulation of actin filament polymerization
GO:0006355  regulation of transcription, DNA-dependent
GO:0009725  response to hormone stimulus

Cellular Component

GO:0005737  cytoplasm
GO:0005739  mitochondrion
GO:0005634  nucleus
GO:0005886  plasma membrane
GO:0005667  transcription factor complex

Molecular Function

GO:0005515  protein binding
GO:0032403  protein complex binding
GO:0019901  protein kinase binding
GO:0017124  SH3 domain binding