hexosaminidase B (beta polypeptide)

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Synonym

HCC-7, HEXB, Beta-hexosaminidase beta chain precursor, hexosaminidase B (beta polypeptide), Cervical cancer proto-oncogene 7, ENC-1AS, N-acetyl-beta-glucosaminidase, Hexosaminidase B, Beta-N-acetylhexosaminidase

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:49.80 cerebellum:25.20 brain stem:- corpus callosum/glia:29.20 pineal gland:148.30 peripheral nerve:153.40 spine:- retina:- eye:29.40 artery/aorta:2937.60 vein:333.20 lymphnode:30.30 peripheral blood:72.90 spleen:94.50 thymus:64.40 bone marrow:19.70 adipose:201.70 bone:127.90 skin:72
GeneChip cerebrum:7.13 cerebellum:6.91 brain stem:7.17 corpus callosum/glia:6.86 pineal gland:- peripheral nerve:7.99 spine:7.22 retina:- eye:- artery/aorta:8.47 vein:8.83 lymphnode:8.13 peripheral blood:- spleen:8.21 thymus:7.65 bone marrow:7.88 adipose:8.46 bone:- skin:8.62
CAGE cerebrum:2.92 cerebellum:- brain stem:2.97 corpus callosum/glia:3.02 pineal gland:3.10 peripheral nerve:- spine:2.75 retina:- eye:- artery/aorta:4.09 vein:3.60 lymphnode:3.58 peripheral blood:- spleen:3.75 thymus:2.95 bone marrow:- adipose:4.68 bone:- skin:-
RNA-seq cerebrum:3.41 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:5.56 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:5.67 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:118.50 placenta:655.70 prostate:67.60 ovary:260.80 testis:8.70 heart:- muscle:- esophagus:342.80 stomach:42.50 intestine:64.80 colon:101.80     liver/hepato:10.60        lung:102.60    bladder:- kidney:124.80 pituitary:- thyroid/parathyroid:491.20 adrenal gland:101.60 pancreas:80 breast:74.30 salivary:-
GeneChip uterus:8.90 placenta:10.25 prostate:9.87 ovary:8.70 testis:6.91 heart:8.33 muscle:7.48 esophagus:7.99 stomach:8.55 intestine:8.72 colon:8.66 liver/hepato:8.31 lung:9.70 bladder:- kidney:8.30 pituitary:7.71 thyroid/parathyroid:9.09 adrenal gland:8.33 pancreas:9.05 breast:8.67 salivary:8.87
CAGE uterus:3.89 placenta:5.85 prostate:3.91 ovary:3.89 testis:3.26 heart:4.04 muscle:2.94 esophagus:3.79 stomach:- intestine:4.27 colon:4.15     liver/hepato:4.38    lung:4.69 bladder:3.93 kidney:4.13 pituitary:3.48 thyroid/parathyroid:4.20 adrenal gland:- pancreas:3.92 breast:4.09 salivary:4.09
RNA-seq uterus:- placenta:- prostate:5.84 ovary:5.73 testis:5.44 heart:5.32 muscle:4.68 esophagus:- stomach:- intestine:- colon:5.82     liver/hepato:5.38        lung:5.94    bladder:- kidney:5.41 pituitary:- thyroid/parathyroid:5.84 adrenal gland:5.23 pancreas:- breast:5.51 salivary:-

Gene Information

IDs

Refseq ID NM_000521
Gene ID 3074
Unigene ID Hs.69293
Probe set ID 201944_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000049860
GTEx ID ENSG00000049860

Orthologous Gene

Mouse[2]  NM_010422
Rat[1]  NM_001011946

Chromosomal Region

5q13.3  [73,935,848  -  74,018,472]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

1054503
1386607
1487253
1531140
1720305
1825792
1967020
2139028
2147027
2147427
2170400
2522450
2525487
2579389
2921040
2948136
2964638
2965147
2966076
2971039
2971395
2977375
3013851
6230359
6959123
7177110
7299841
7557963
7626071
7633435
8045559
8106452
8357844
8634145
8663217
8673609
8950198
9401004
9694901
9856491
9888387
10571007
10591618
10982028
11447134
12413610
12477932
12662933
12706724
12754519
14702039
15459180
15485660
15489334
15953731
16352452
16710745
17251047
18180457
18204279
18217416
18552385
18588514
18758829
18930675
19278737
19615986
19913121
19946888
20628086
20800603
21307379
21321400
21637923
21890473
21900206
21906983
21978926
22191674
22268729
22789865
22848519
22863301
22863883
23046579
23349634
23370522
23886397
23906468

Gene Ontology  (GO ID)

Biological Process

GO:0043615  astrocyte cell migration
GO:0005975  carbohydrate metabolic process
GO:0008219  cell death
GO:0006874  cellular calcium ion homeostasis
GO:0044267  cellular protein metabolic process
GO:0030207  chondroitin sulfate catabolic process
GO:0030204  chondroitin sulfate metabolic process
GO:0006689  ganglioside catabolic process
GO:0030203  glycosaminoglycan metabolic process
GO:0006687  glycosphingolipid metabolic process
GO:0030214  hyaluronan catabolic process
GO:0030212  hyaluronan metabolic process
GO:0042340  keratan sulfate catabolic process
GO:0042339  keratan sulfate metabolic process
GO:0019915  lipid storage
GO:0007626  locomotory behavior
GO:0007040  lysosome organization
GO:0008049  male courtship behavior
GO:0042552  myelination
GO:0050885  neuromuscular process controlling balance
GO:0009313  oligosaccharide catabolic process
GO:0048477  oogenesis
GO:0007341  penetration of zona pellucida
GO:0008654  phospholipid biosynthetic process
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0008360  regulation of cell shape
GO:0007605  sensory perception of sound
GO:0001501  skeletal system development
GO:0006665  sphingolipid metabolic process

Cellular Component

GO:0001669  acrosomal vesicle
GO:0043202  lysosomal lumen
GO:0016020  membrane

Molecular Function

GO:0004563  beta-N-acetylhexosaminidase activity
GO:0046982  protein heterodimerization activity
GO:0042803  protein homodimerization activity