major histocompatibility complex, class II, DM alpha

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Synonym

HLADM, DMA, D6S222E, MHC class II antigen DMA, RING6, HLA-DMA

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:19 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:61.30 spine:- retina:- eye:82.30 artery/aorta:- vein:- lymphnode:141.50 peripheral blood:674.10 spleen:245.80 thymus:141.70 bone marrow:216.50 adipose:121 bone:127.90 skin:384
GeneChip cerebrum:6.05 cerebellum:5.45 brain stem:6.56 corpus callosum/glia:7.42 pineal gland:- peripheral nerve:8.30 spine:7.92 retina:- eye:- artery/aorta:8.24 vein:7.66 lymphnode:9.82 peripheral blood:- spleen:9.88 thymus:8.44 bone marrow:8.20 adipose:8.93 bone:- skin:7.96
CAGE cerebrum:2.81 cerebellum:- brain stem:3.58 corpus callosum/glia:3.89 pineal gland:2.96 peripheral nerve:- spine:3.96 retina:- eye:- artery/aorta:4.22 vein:5.12 lymphnode:4.93 peripheral blood:- spleen:4.84 thymus:4.20 bone marrow:- adipose:4.61 bone:- skin:-
RNA-seq cerebrum:3.35 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:5.82 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:5.20 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:164 placenta:80.10 prostate:112.60 ovary:111.80 testis:21.60 heart:63.90 muscle:100.50 esophagus:- stomach:42.50 intestine:97.20 colon:50.90     liver/hepato:21.10        lung:342.10    bladder:125.60 kidney:31.20 pituitary:116 thyroid/parathyroid:- adrenal gland:101.60 pancreas:53.30 breast:120.80 salivary:656.80
GeneChip uterus:7.68 placenta:6.75 prostate:7.26 ovary:8.18 testis:5.64 heart:7.53 muscle:6.35 esophagus:7.50 stomach:8.67 intestine:8.08 colon:8.15 liver/hepato:6.99 lung:10.18 bladder:- kidney:7.67 pituitary:6.67 thyroid/parathyroid:8.10 adrenal gland:7.84 pancreas:7.64 breast:8.53 salivary:8.98
CAGE uterus:3.77 placenta:3.20 prostate:3.77 ovary:3.59 testis:2.70 heart:3.56 muscle:2.47 esophagus:3.26 stomach:- intestine:4.84 colon:3.89     liver/hepato:3.08    lung:5.18 bladder:3.36 kidney:4.39 pituitary:3.08 thyroid/parathyroid:3.71 adrenal gland:- pancreas:3.61 breast:3.47 salivary:4.56
RNA-seq uterus:- placenta:- prostate:5.20 ovary:4.64 testis:4.10 heart:3.89 muscle:3.03 esophagus:- stomach:- intestine:- colon:3.65     liver/hepato:2.26        lung:6.52    bladder:- kidney:4.95 pituitary:- thyroid/parathyroid:3.87 adrenal gland:6.12 pancreas:- breast:5.28 salivary:-

Gene Information

IDs

Refseq ID NM_006120
Gene ID 3108
Unigene ID Hs.351279
Probe set ID 217478_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000204257
GTEx ID ENSG00000204257

Orthologous Gene

Mouse[1]  NM_010386
Rat [0]  

Chromosomal Region

HSCHR6_MHC_APD  [32,899,979  -  32,904,491]
6p21.32  [32,916,390  -  32,938,493]
HSCHR6_MHC_COX  [32,838,712  -  32,860,827]
HSCHR6_MHC_SSTO  [33,006,288  -  33,028,403]
HSCHR6_MHC_QBL  [32,845,119  -  32,867,240]
HSCHR6_MHC_MCF  [32,949,846  -  32,971,961]
HSCHR6_MHC_DBB  [32,894,331  -  32,898,843]
HSCHR6_MHC_MANN  [33,070,204  -  33,092,323]

Gene Family (Interpro ID)

IPR001003  MHC class II, alpha chain, N-terminal
IPR014745  MHC class II, alpha/beta chain, N-terminal
IPR011162  MHC classes I/II-like antigen recognition protein

Link to Pubmed  (Pubmed ID)

1869305
1922365
1922385
1967269
1978941
2543930
2846691
3489470
7512597
7541827
7602119
8026867
8034636
8084338
8139690
8168144
8225438
8376762
8568858
8574855
8849454
8890155
8947036
9079699
9311912
9371817
9551909
9759843
9768757
9879837
10322421
10631952
10661406
10716924
10729169
11048639
11070170
11118314
11168931
11180452
11337467
11441095
11593029
11739502
11743588
11775239
11827988
11881821
11956296
12392850
12427289
12477932
12648225
12663675
12728471
12742663
12786997
12794545
12836198
12858445
12928384
12970439
14754527
15078178
15194762
15489916
15547082
15547089
15723810
16091223
16354571
16435885
16454711
16737583
16864101
17015729
17652306
17959659
18348411
18779172
18945465
19115949
19149577
19449444
19620308
19770068
19851445
19913121
19946888
20012522
20237496
20408893
20628086
21059907
21778700
21922073
21988832
22103833
22103834
22175768
22309257
22498736
22860026
23260142

Gene Ontology  (GO ID)

Biological Process

GO:0019886  antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0051085  chaperone mediated protein folding requiring cofactor
GO:0016064  immunoglobulin mediated immune response
GO:0048839  inner ear development
GO:0050778  positive regulation of immune response
GO:0045582  positive regulation of T cell differentiation
GO:0045059  positive thymic T cell selection
GO:0006461  protein complex assembly
GO:0015031  protein transport

Cellular Component

GO:0016021  integral to membrane
GO:0031902  late endosome membrane
GO:0005765  lysosomal membrane
GO:0042613  MHC class II protein complex
GO:0005771  multivesicular body