major histocompatibility complex, class II, DP alpha 1

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Synonym

HLA-DPA1, HLADP, HLA-DP1A, HLA-SB alpha chain, DP(W4), MHC class II DP3-alpha, HLASB, DP(W3)

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:60.40 cerebellum:50.40 brain stem:- corpus callosum/glia:116.60 pineal gland:148.30 peripheral nerve:30.70 spine:112.30 retina:118.60 eye:117.50 artery/aorta:209.80 vein:- lymphnode:91 peripheral blood:164 spleen:189.10 thymus:90.20 bone marrow:137.80 adipose:403.30 bone:255.90 skin:316.80
GeneChip cerebrum:8.20 cerebellum:7.44 brain stem:9.13 corpus callosum/glia:9.74 pineal gland:- peripheral nerve:10.93 spine:10.53 retina:- eye:- artery/aorta:10.57 vein:10.14 lymphnode:11.68 peripheral blood:- spleen:11.72 thymus:11.13 bone marrow:9.69 adipose:10.64 bone:- skin:10.18
CAGE cerebrum:4.58 cerebellum:- brain stem:5.57 corpus callosum/glia:5.86 pineal gland:4.66 peripheral nerve:- spine:6.13 retina:- eye:- artery/aorta:6.16 vein:6.60 lymphnode:7.01 peripheral blood:- spleen:6.97 thymus:6.57 bone marrow:- adipose:6.16 bone:- skin:-
RNA-seq cerebrum:0 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:136.70 placenta:43.70 prostate:112.60 ovary:149.10 testis:73.50 heart:38.30 muscle:20.10 esophagus:- stomach:127.50 intestine:259.20 colon:76.30     liver/hepato:21.10        lung:332.40    bladder:- kidney:93.60 pituitary:347.90 thyroid/parathyroid:- adrenal gland:355.50 pancreas:177.80 breast:27.90 salivary:-
GeneChip uterus:9.77 placenta:8.54 prostate:10.11 ovary:10.16 testis:7.98 heart:9.79 muscle:8.30 esophagus:9.87 stomach:10.38 intestine:10.14 colon:9.93 liver/hepato:9.50 lung:12.17 bladder:- kidney:9.64 pituitary:9.29 thyroid/parathyroid:10.15 adrenal gland:10.35 pancreas:9.41 breast:10.39 salivary:9.61
CAGE uterus:5.54 placenta:4.53 prostate:5.83 ovary:5.12 testis:4.46 heart:5.22 muscle:4.20 esophagus:5.04 stomach:- intestine:5.91 colon:5.14     liver/hepato:5.45    lung:7.11 bladder:5.21 kidney:5.89 pituitary:4.74 thyroid/parathyroid:4.61 adrenal gland:- pancreas:4.92 breast:4.75 salivary:5.64
RNA-seq uterus:- placenta:- prostate:0 ovary:0 testis:0 heart:0 muscle:0 esophagus:- stomach:- intestine:- colon:0     liver/hepato:0        lung:0    bladder:- kidney:0 pituitary:- thyroid/parathyroid:0 adrenal gland:0 pancreas:- breast:0 salivary:-

Gene Information

IDs

Refseq ID NM_033554
Gene ID 3113
Unigene ID Hs.347270
Probe set ID 211990_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000168384
ENSG00000229685
ENSG00000231389
ENSG00000235844
ENSG00000236177
GTEx ID ENSG00000168384
ENSG00000229685
ENSG00000231389
ENSG00000235844
ENSG00000236177

Orthologous Gene

Mouse [0]  
Rat [0]  

Chromosomal Region

HSCHR6_MHC_APD  [33,015,768  -  33,031,962]
6p21.32  [33,032,346  -  33,048,552]
HSCHR6_MHC_COX  [32,954,322  -  32,970,527]
HSCHR6_MHC_SSTO  [33,171,992  -  33,188,198]
HSCHR6_MHC_QBL  [32,961,400  -  32,977,612]
HSCHR6_MHC_MCF  [33,065,822  -  33,082,016]
HSCHR6_MHC_DBB  [33,010,288  -  33,026,494]
HSCHR6_MHC_MANN  [33,186,489  -  33,202,701]

Gene Family (Interpro ID)

IPR001003  MHC class II, alpha chain, N-terminal
IPR014745  MHC class II, alpha/beta chain, N-terminal
IPR011162  MHC classes I/II-like antigen recognition protein

Link to Pubmed  (Pubmed ID)

1869305
1967269
1978941
2461352
2543930
2578218
2846691
2987832
2997750
3036829
3266023
3489470
6300884
6325928
6584734
7512597
7541827
7602119
7725312
7912458
8084338
8168144
8376762
8454872
8568247
8649448
8773319
8889548
9079699
9366419
9694359
10090623
10661406
10729169
10958363
11019928
11048639
11118314
11556979
11593029
11777970
11827988
12073072
12427289
12445315
12477932
12580031
12707403
12778461
12836198
12899833
12910711
12956878
12970439
15041165
15078178
15121303
15191952
15194762
15304007
15342556
15489916
15603877
15663751
15713216
16042197
16091223
16098233
16242130
16354571
16454711
16465617
17060025
17234427
17652306
17785583
17959659
18593440
18784467
18945465
19143812
19143818
19149577
19200828
19349983
19449444
19589487
19620308
19722042
19770068
19795399
19851445
19896518
19913121
20012522
20237496
20376809
20424227
20462405
20470845
20595243
20628086
20668555
21059907
21274863
21346778
21399633
21402545
21750111
21778700
21779181
21814517
21922073
22103833
22103834
22105689
22175768
22448225
22496224
22737229
22860026
22923493
23180272
23326374
23428460
23449268
23459078
23760081
23825586
24006435
24462895

Gene Ontology  (GO ID)

Biological Process

GO:0019886  antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0071346  cellular response to interferon-gamma
GO:0019221  cytokine-mediated signaling pathway
GO:0006955  immune response
GO:0060333  interferon-gamma-mediated signaling pathway
GO:0031295  T cell costimulation
GO:0050852  T cell receptor signaling pathway

Cellular Component

GO:0030669  clathrin-coated endocytic vesicle membrane
GO:0030666  endocytic vesicle membrane
GO:0010008  endosome membrane
GO:0012507  ER to Golgi transport vesicle membrane
GO:0000139  Golgi membrane
GO:0005887  integral to plasma membrane
GO:0005765  lysosomal membrane
GO:0042613  MHC class II protein complex
GO:0005886  plasma membrane
GO:0032588  trans-Golgi network membrane
GO:0030658  transport vesicle membrane

Molecular Function

GO:0032395  MHC class II receptor activity