major histocompatibility complex, class II, DQ alpha 2

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Synonym

HLA-DXA, HLA-DQA1, DQ alpha, HLA-DQA2, DX alpha chain

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:5.90 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:60 vein:- lymphnode:10.10 peripheral blood:- spleen:18.90 thymus:- bone marrow:196.80 adipose:- bone:- skin:43.20
GeneChip cerebrum:4.67 cerebellum:4.51 brain stem:5.10 corpus callosum/glia:6.14 pineal gland:- peripheral nerve:7.37 spine:6.91 retina:- eye:- artery/aorta:7.67 vein:6.13 lymphnode:9.70 peripheral blood:- spleen:9.54 thymus:9.63 bone marrow:7.07 adipose:7.94 bone:- skin:7.93
CAGE cerebrum:1.13 cerebellum:- brain stem:1.37 corpus callosum/glia:2.63 pineal gland:1.10 peripheral nerve:- spine:2.07 retina:- eye:- artery/aorta:3.28 vein:5.79 lymphnode:5.35 peripheral blood:- spleen:5.10 thymus:5.07 bone marrow:- adipose:2.15 bone:- skin:-
RNA-seq cerebrum:0 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:25.50 muscle:- esophagus:- stomach:- intestine:- colon:8.50     liver/hepato:-        lung:78.20    bladder:- kidney:10.40 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:8.90 breast:9.30 salivary:-
GeneChip uterus:6.59 placenta:6.32 prostate:6.94 ovary:6.42 testis:4.63 heart:6.24 muscle:4.89 esophagus:7.12 stomach:7.67 intestine:7.24 colon:7.10 liver/hepato:6.37 lung:10.41 bladder:- kidney:6.47 pituitary:5.78 thyroid/parathyroid:7.04 adrenal gland:6.44 pancreas:6.26 breast:7.64 salivary:6.57
CAGE uterus:3.35 placenta:2.44 prostate:3.72 ovary:1.29 testis:1.87 heart:2.29 muscle:1.16 esophagus:1.34 stomach:- intestine:4.00 colon:2.68     liver/hepato:2.79    lung:3.74 bladder:1.86 kidney:4.08 pituitary:1.21 thyroid/parathyroid:2.89 adrenal gland:- pancreas:0.94 breast:1.16 salivary:3.75
RNA-seq uterus:- placenta:- prostate:0 ovary:0 testis:0 heart:0 muscle:0 esophagus:- stomach:- intestine:- colon:0     liver/hepato:0        lung:0    bladder:- kidney:0 pituitary:- thyroid/parathyroid:0 adrenal gland:0 pancreas:- breast:0 salivary:-

Gene Information

IDs

Refseq ID NM_020056
Gene ID 3118
Unigene ID Hs.591798
Probe set ID 212671_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000237541
GTEx ID ENSG00000237541

Orthologous Gene

Mouse [0]  
Rat [0]  

Chromosomal Region

HSCHR6_MHC_APD  [32,694,039  -  32,700,103]
6p21.32  [32,709,119  -  32,714,992]
HSCHR6_MHC_COX  [32,632,816  -  32,638,891]
HSCHR6_MHC_QBL  [32,637,805  -  32,643,664]
HSCHR6_MHC_MCF  [32,742,904  -  32,748,772]
HSCHR6_MHC_DBB  [32,688,301  -  32,694,153]
HSCHR6_MHC_MANN  [32,862,880  -  32,868,441]
HSCHR6_MHC_SSTO  [32,799,929  -  32,805,799]

Gene Family (Interpro ID)

IPR001003  MHC class II, alpha chain, N-terminal
IPR014745  MHC class II, alpha/beta chain, N-terminal
IPR011162  MHC classes I/II-like antigen recognition protein

Link to Pubmed  (Pubmed ID)

1362295
1612647
1869305
1967269
1978941
2513578
2543930
2846691
3036828
3372263
3489470
3610256
6300884
6584734
7512597
7541827
7602119
8026991
8084338
8168144
8376762
9036956
9079699
10661406
10729169
11048639
11118314
11376336
11535811
11593029
11827988
12427289
12477932
12836198
12970439
15078178
15194762
15489916
16091223
16354571
16454711
17554300
17652306
17959659
18065200
18668548
18945465
19116923
19149577
19449444
19620308
19770068
19851445
20012522
20159242
20237496
20305777
20587610
20596022
20711174
21059907
21102463
21408207
21778700
21804548
21922073
22075330
22096524
22103833
22103834
22125590
22175768
22407913
22493691
22693455
22860026
23053960
23146381
23257407
23266558
23284291
23349640
23382691
23472185
23918589

Gene Ontology  (GO ID)

Biological Process

GO:0019886  antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0019221  cytokine-mediated signaling pathway
GO:0006955  immune response
GO:0060333  interferon-gamma-mediated signaling pathway
GO:0031295  T cell costimulation
GO:0050852  T cell receptor signaling pathway

Cellular Component

GO:0030669  clathrin-coated endocytic vesicle membrane
GO:0030666  endocytic vesicle membrane
GO:0010008  endosome membrane
GO:0012507  ER to Golgi transport vesicle membrane
GO:0000139  Golgi membrane
GO:0005887  integral to plasma membrane
GO:0005765  lysosomal membrane
GO:0042613  MHC class II protein complex
GO:0005886  plasma membrane
GO:0032588  trans-Golgi network membrane
GO:0030658  transport vesicle membrane

Molecular Function

GO:0032395  MHC class II receptor activity