major histocompatibility complex, class II, DR alpha

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Synonym

MHC class II antigen DRA, HLA-DRA, HLA-DRA1

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:48.60

cerebellum:25.20

brain stem:-

corpus callosum/glia:-

pineal gland:296.70

peripheral nerve:122.70

spine:224.60

retina:-

eye:123.40

artery/aorta:359.70

vein:-

lymphnode:748.20

peripheral blood:309.70

spleen:548.30

thymus:116

bone marrow:1102.10

adipose:121

bone:127.90

skin:916.80

GeneChip

cerebrum:7.06

cerebellum:5.49

brain stem:8.04

corpus callosum/glia:8.65

pineal gland:-

peripheral nerve:9.74

spine:9.42

retina:-

eye:-

artery/aorta:9.10

vein:8.55

lymphnode:10.67

peripheral blood:-

spleen:10.67

thymus:10.46

bone marrow:9.23

adipose:9.73

bone:-

skin:9.54

CAGE

cerebrum:4.85

cerebellum:-

brain stem:5.65

corpus callosum/glia:5.81

pineal gland:5.06

peripheral nerve:-

spine:6.47

retina:-

eye:-

artery/aorta:6.21

vein:7.37

lymphnode:7.37

peripheral blood:-

spleen:7.39

thymus:6.50

bone marrow:-

adipose:6.28

bone:-

skin:-

RNA-seq

cerebrum:0

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:802

placenta:120.20

prostate:123.90

ovary:149.10

testis:116.80

heart:102.20

muscle:100.50

esophagus:-

stomach:531.10

intestine:162

colon:127.20

liver/hepato:126.70

lung:830.90

bladder:-

kidney:135.20

pituitary:-

thyroid/parathyroid:163.70

adrenal gland:711

pancreas:97.80

breast:139.40

salivary:-

GeneChip

uterus:8.88

placenta:8.07

prostate:9.16

ovary:9.37

testis:6.67

heart:8.68

muscle:7.28

esophagus:8.78

stomach:9.33

intestine:9.35

colon:9.13

liver/hepato:7.88

lung:11.41

bladder:-

kidney:8.60

pituitary:7.82

thyroid/parathyroid:8.48

adrenal gland:8.52

pancreas:8.53

breast:9.45

salivary:8.69

CAGE

uterus:5.70

placenta:4.97

prostate:5.86

ovary:5.43

testis:4.70

heart:5.43

muscle:4.58

esophagus:5.51

stomach:-

intestine:7.12

colon:5.81

liver/hepato:5.44

lung:7.56

bladder:5.79

kidney:6.77

pituitary:5.03

thyroid/parathyroid:5.24

adrenal gland:-

pancreas:4.99

breast:4.70

salivary:5.77

RNA-seq

uterus:-

placenta:-

prostate:0

ovary:0

testis:0

heart:0

muscle:0

esophagus:-

stomach:-

intestine:-

colon:0

liver/hepato:0

lung:0

bladder:-

kidney:0

pituitary:-

thyroid/parathyroid:0

adrenal gland:0

pancreas:-

breast:0

salivary:-

IDs

Refseq ID	NM_019111
Gene ID	3122
Unigene ID	Hs.520048
Probe set ID	208894_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000204287
GTEx ID	ENSG00000204287

Orthologous Gene

Mouse [0]
Rat [0]

Chromosomal Region

HSCHR6_MHC_COX [32,355,870 - 32,361,037]

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HSCHR6_MHC_QBL [32,365,090 - 32,370,300]

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HSCHR6_MHC_MCF [32,482,996 - 32,488,206]

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HSCHR6_MHC_DBB [32,382,335 - 32,387,545]

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6p21.32 [32,407,619 - 32,412,823]

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HSCHR6_MHC_MANN [32,446,282 - 32,451,493]

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HSCHR6_MHC_SSTO [32,413,425 - 32,418,635]

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Gene Family (Interpro ID)

IPR001003	MHC class II, alpha chain, N-terminal
IPR014745	MHC class II, alpha/beta chain, N-terminal
IPR011162	MHC classes I/II-like antigen recognition protein

Gene Ontology (GO ID)

Biological Process

GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0019221	cytokine-mediated signaling pathway
GO:0006955	immune response
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0031295	T cell costimulation
GO:0050852	T cell receptor signaling pathway

Cellular Component

GO:0030669	clathrin-coated endocytic vesicle membrane
GO:0030666	endocytic vesicle membrane
GO:0012507	ER to Golgi transport vesicle membrane
GO:0000139	Golgi membrane
GO:0005887	integral to plasma membrane
GO:0031902	late endosome membrane
GO:0005765	lysosomal membrane
GO:0005764	lysosome
GO:0042613	MHC class II protein complex
GO:0005886	plasma membrane
GO:0032588	trans-Golgi network membrane
GO:0030658	transport vesicle membrane

Molecular Function

GO:0032395

MHC class II receptor activity

major histocompatibility complex, class II, DR alpha

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function