major histocompatibility complex, class II, DR beta 4

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Synonym

HLA DRB1, HLA-DR4B, DRB4, HLA-DRB4

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

nodata

GeneChip

nodata

CAGE

nodata

RNA-seq

cerebrum:0

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

nodata

GeneChip

nodata

CAGE

nodata

RNA-seq

uterus:-

placenta:-

prostate:0

ovary:0

testis:0

heart:0

muscle:0

esophagus:-

stomach:-

intestine:-

colon:0

liver/hepato:0

lung:0

bladder:-

kidney:0

pituitary:-

thyroid/parathyroid:0

adrenal gland:0

pancreas:-

breast:0

salivary:-

IDs

Refseq ID	NM_021983
Gene ID	3126
Unigene ID	-
Probe set ID	-
Ensembl ID	ENSG00000227357 ENSG00000231021
GTEx ID	ENSG00000227357 ENSG00000231021

Orthologous Gene

Mouse [0]
Rat [0]

Chromosomal Region

HSCHR6_MHC_MCF [32,578,924 - 32,593,887]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

HSCHR6_MHC_SSTO [32,509,573 - 32,524,536]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR014745	MHC class II, alpha/beta chain, N-terminal
IPR000353	MHC class II, beta chain, N-terminal
IPR011162	MHC classes I/II-like antigen recognition protein

Gene Ontology (GO ID)

Biological Process

GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0019221	cytokine-mediated signaling pathway
GO:0016045	detection of bacterium
GO:0002455	humoral immune response mediated by circulating immunoglobulin
GO:0006955	immune response
GO:0002381	immunoglobulin production during immune response
GO:0002437	inflammatory response to antigenic stimulus
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0002862	negative regulation of inflammatory response to antigenic stimulus
GO:0032689	negative regulation of interferon-gamma production
GO:0042130	negative regulation of T cell proliferation
GO:0051262	protein tetramerization
GO:0032673	regulation of interleukin-4 production
GO:0007165	signal transduction
GO:0031295	T cell costimulation
GO:0050852	T cell receptor signaling pathway
GO:0042088	T-helper 1 type immune response

Cellular Component

GO:0030669	clathrin-coated endocytic vesicle membrane
GO:0030666	endocytic vesicle membrane
GO:0012507	ER to Golgi transport vesicle membrane
GO:0009897	external side of plasma membrane
GO:0000139	Golgi membrane
GO:0005887	integral to plasma membrane
GO:0031902	late endosome membrane
GO:0005765	lysosomal membrane
GO:0042613	MHC class II protein complex
GO:0005886	plasma membrane
GO:0032588	trans-Golgi network membrane
GO:0030658	transport vesicle membrane

Molecular Function

GO:0032395	MHC class II receptor activity
GO:0042605	peptide antigen binding
GO:0005515	protein binding

major histocompatibility complex, class II, DR beta 4

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function