3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)

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Synonym

HMGCS1, HMG-CoA synthase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, MGC90332, Hydroxymethylglutaryl-CoA synthase, cytoplasmic, HMGCS

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:282.10 cerebellum:75.60 brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:153.40 spine:673.80 retina:118.60 eye:41.10 artery/aorta:60 vein:- lymphnode:131.40 peripheral blood:91.10 spleen:56.70 thymus:77.30 bone marrow:19.70 adipose:- bone:51.20 skin:153.60
GeneChip cerebrum:7.28 cerebellum:6.29 brain stem:7.46 corpus callosum/glia:6.93 pineal gland:- peripheral nerve:8.17 spine:7.79 retina:- eye:- artery/aorta:6.36 vein:5.90 lymphnode:6.46 peripheral blood:- spleen:5.81 thymus:6.12 bone marrow:4.78 adipose:6.38 bone:- skin:7.66
CAGE cerebrum:3.70 cerebellum:- brain stem:4.06 corpus callosum/glia:4.04 pineal gland:3.01 peripheral nerve:- spine:4.27 retina:- eye:- artery/aorta:2.69 vein:2.39 lymphnode:3.41 peripheral blood:- spleen:2.61 thymus:2.36 bone marrow:- adipose:2.25 bone:- skin:-
RNA-seq cerebrum:5.51 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.21 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.09 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:54.70 placenta:65.60 prostate:56.30 ovary:- testis:86.50 heart:51.10 muscle:20.10 esophagus:- stomach:63.70 intestine:129.60 colon:42.40     liver/hepato:253.30        lung:161.30    bladder:125.60 kidney:83.20 pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:35.60 breast:37.20 salivary:-
GeneChip uterus:6.54 placenta:6.33 prostate:7.72 ovary:6.59 testis:6.63 heart:5.90 muscle:5.43 esophagus:8.09 stomach:6.74 intestine:6.89 colon:6.24 liver/hepato:8.09 lung:6.73 bladder:- kidney:6.02 pituitary:6.30 thyroid/parathyroid:6.15 adrenal gland:7.78 pancreas:5.51 breast:6.83 salivary:5.73
CAGE uterus:3.29 placenta:2.64 prostate:2.76 ovary:3.91 testis:3.13 heart:2.39 muscle:1.29 esophagus:5.15 stomach:- intestine:4.04 colon:2.69     liver/hepato:4.37    lung:4.60 bladder:3.16 kidney:3.55 pituitary:2.82 thyroid/parathyroid:2.50 adrenal gland:- pancreas:2.76 breast:3.30 salivary:2.78
RNA-seq uterus:- placenta:- prostate:3.36 ovary:5.65 testis:3.65 heart:1.43 muscle:0.00 esophagus:- stomach:- intestine:- colon:2.80     liver/hepato:6.27        lung:5.52    bladder:- kidney:4.38 pituitary:- thyroid/parathyroid:4.01 adrenal gland:3.57 pancreas:- breast:3.56 salivary:-

Gene Information

IDs

Refseq ID NM_002130
Gene ID 3157
Unigene ID Hs.397729
Probe set ID 221750_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000112972
GTEx ID ENSG00000112972

Orthologous Gene

Mouse[4]  NM_145942
Rat [0]  

Chromosomal Region

5p12  [43,289,497  -  43,313,614]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

1358203
1971108
2870496
2877984
3470763
7913309
12477932
14702039
15489334
16344560
17081983
18029348
18636124
18660489
18854154
19088433
20346956
21139048
21890473
21906983
21963094
22053931
22505724
22939629
23000965
23464991
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0007420  brain development
GO:0044255  cellular lipid metabolic process
GO:0071397  cellular response to cholesterol
GO:0071372  cellular response to follicle-stimulating hormone stimulus
GO:0006695  cholesterol biosynthetic process
GO:0008299  isoprenoid biosynthetic process
GO:0006629  lipid metabolic process
GO:0001889  liver development
GO:0008584  male gonad development
GO:0001101  response to acid
GO:0042493  response to drug
GO:0055094  response to lipoprotein stimulus
GO:0009645  response to low light intensity stimulus
GO:0014074  response to purine
GO:0046690  response to tellurium ion
GO:0033197  response to vitamin E

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005730  nucleolus
GO:0005634  nucleus
GO:0005886  plasma membrane

Molecular Function

GO:0008144  drug binding
GO:0004421  hydroxymethylglutaryl-CoA synthase activity
GO:0016853  isomerase activity
GO:0043177  organic acid binding
GO:0042803  protein homodimerization activity