heme oxygenase (decycling) 1

jump to detail

Synonym

heme oxygenase (decycling) 1, HO, HO-1, HMOX1, bK286B10, Heme oxygenase 1, heme oxygenase-1, heme oxygenase-1 (HO-1), HO1

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:13 cerebellum:- brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:- spine:- retina:- eye:76.40 artery/aorta:119.90 vein:133.30 lymphnode:- peripheral blood:510.10 spleen:434.80 thymus:25.80 bone marrow:19.70 adipose:40.30 bone:51.20 skin:24
GeneChip cerebrum:5.62 cerebellum:5.06 brain stem:5.83 corpus callosum/glia:6.10 pineal gland:- peripheral nerve:6.03 spine:6.53 retina:- eye:- artery/aorta:6.46 vein:6.18 lymphnode:6.94 peripheral blood:- spleen:8.14 thymus:5.78 bone marrow:7.80 adipose:6.82 bone:- skin:7.30
CAGE cerebrum:2.94 cerebellum:- brain stem:3.48 corpus callosum/glia:3.57 pineal gland:2.59 peripheral nerve:- spine:4.12 retina:- eye:- artery/aorta:4.54 vein:4.46 lymphnode:4.94 peripheral blood:- spleen:7.04 thymus:2.90 bone marrow:- adipose:4.82 bone:- skin:-
RNA-seq cerebrum:2.41 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:5.92 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.77 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:346.10 prostate:- ovary:111.80 testis:13 heart:25.50 muscle:- esophagus:- stomach:21.20 intestine:- colon:33.90     liver/hepato:31.70        lung:68.40    bladder:- kidney:52 pituitary:- thyroid/parathyroid:- adrenal gland:101.60 pancreas:17.80 breast:27.90 salivary:-
GeneChip uterus:5.78 placenta:7.79 prostate:5.21 ovary:6.60 testis:6.06 heart:6.25 muscle:5.83 esophagus:7.10 stomach:5.55 intestine:6.59 colon:6.20 liver/hepato:7.03 lung:6.78 bladder:- kidney:6.92 pituitary:5.31 thyroid/parathyroid:5.33 adrenal gland:5.92 pancreas:6.20 breast:6.01 salivary:5.39
CAGE uterus:2.79 placenta:4.69 prostate:3.13 ovary:4.98 testis:3.74 heart:3.78 muscle:3.76 esophagus:3.81 stomach:- intestine:4.82 colon:3.89     liver/hepato:5.70    lung:5.10 bladder:3.68 kidney:4.82 pituitary:2.24 thyroid/parathyroid:3.14 adrenal gland:- pancreas:2.54 breast:4.44 salivary:2.31
RNA-seq uterus:- placenta:- prostate:3.27 ovary:5.93 testis:3.39 heart:1.83 muscle:3.89 esophagus:- stomach:- intestine:- colon:2.58     liver/hepato:6.62        lung:5.62    bladder:- kidney:5.36 pituitary:- thyroid/parathyroid:4.05 adrenal gland:5.45 pancreas:- breast:4.09 salivary:-

IDs

Refseq ID NM_002133
Gene ID 3162
Unigene ID Hs.517581
Probe set ID 203665_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000100292
GTEx ID ENSG00000100292

Orthologous Gene

Mouse[1]  NM_010442
Rat [0]  

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

2537723
2911585
3345742
7778849
8034330
8146161
8650873
9884342
9890653
10082382
10467099
10591208
10631150
10952020
11385506
11718398
11727267
11786534
11820797
11829463
11849436
11986386
12086318
12091240
12099373
12117910
12118938
12130498
12133007
12136229
12151344
12153964
12182912
12202863
12207883
12222997
12239590
12376298
12376363
12376366
12377749
12379283
12396617
12397597
12431619
12433915
12469218
12477932
12480749
12493432
12500973
12511571
12566526
12579334
12585963
12626517
12649161
12679469
12690112
12709566
12709568
12709569
12709590
12709592
12716475
12730098
12736395
12761501
12777398
12783778
12805077
12810075
12832044
12842469
12865654
12872043
12891549
12909459
12927812
12927819
12933701
12941774
12947311
12969148
13678532
14521259
14523007
14525760
14529548
14587309
14615405
14635185
14647439
14660632
14683741
14691581
14715242
14726403
14733911
14981149
14988408
14992466
15004156
15024026
15028349
15049686
15064108
15084931
15140586
15161530
15166181
15184199
15233805
15284058
15285018
15297453
15316927
15319861
15336443
15337692
15342556
15365571
15451051
15461802
15465821
15470195
15474356
15516695
15519649
15522396
15525643
15544924
15547665
15581622
15611319
15618017
15629867
15652505
15661856
15688187
15690204
15741166
15763346
15797262
15797755
15805230
15817713
15833736
15834587
15849554
15875813
15878918
15885363
15897578
15899048
15964514
16020495
16100019
16117883
16123320
16154535
16181102
16189191
16210136
16232329
16234431
16249618
16271489
16309585
16309586
16309588
16313248
16319139
16374439
16387424
16399210
16455537
16462769
16474202
16485041
16495813
16530877
16540907
16545694
16582079
16596642
16609364
16620829
16697692
16712795
16724942
16771696
16772700
16783602
16804400
16840713
16849502
16882737
16887359
16923960
16945925
16950787
16951197
16971418
16999951
17003650
17018578
17018862
17020887
17064313
17065227
17079780
17081983
17095719
17203192
17204476
17211576
17216339
17219054
17229906
17244614
17254481
17277740
17295091
17389623
17391133
17400606
17413033
17452746
17467999
17511591
17520317
17526019
17526500
17531161
17541213
17558910
17567933
17600318
17601350
17603281
17620093
17652371
17657593
17667816
17721824
17726138
17823375
17853070
17873285
17883332
17886034
17896171
17915953
17919491
17919492
17927807
17953374
17964723
17971338
17991645
18007994
18042465
18045827
18048809
18050210
18077487
18093274
18174022
18195184
18200441
18201862
18202225
18205746
18216050
18234118
18261117
18272347
18274635
18275848
18289072
18307065
18312299
18332044
18344023
18381758
18390757
18404535
18443197
18459998
18460015
18461097
18483307
18502573
18508827
18515325
18524839
18544348
18550526
18560362
18566988
18576916
18582925
18586007
18587252
18596041
18597895
18620357
18640487
18651163
18665050
18689604
18692581
18757839
18769149
18774956
18786476
18787101
18799519
18804049
18811919
18841019
18845641
18923065
18930811
18957281
18975324
18977241
18981090
18983509
19056482
19120903
19122175
19129475
19133325
19165391
19194559
19236506
19238116
19243019
19243105
19246912
19250338
19255063
19255829
19282863
19289500
19303319
19322201
19325051
19336475
19360326
19371606
19389234
19399816
19422386
19428335
19445907
19457084
19457866
19475336
19484149
19487598
19508729
19522732
19526221
19526463
19536150
19548360
19556236
19578796
19586801
19587144
19590927
19604147
19625608
19669099
19676145
19696228
19777608
19785642
19797297
19808663
19808972
19822148
19850937
19853072
19874887
19879747
19884647
19886851
19895178
19903700
19903769
19910578
19913121
19924377
19925812
19965783
20013271
20020468
20021945
20039940
20049130
20064636
20110814
20121710
20127796
20155807
20170613
20175935
20188821
20190330
20193368
20194081
20223113
20229611
20232486
20299368
20345481
20345975
20346360
20351094
20386498
20395442
20404253
20416077
20430037
20446774
20482362
20485444
20504881
20508205
20509889
20518850
20526373
20580464
20585394
20587610
20597111
20599261
20628086
20633528
20667089
20682519
20689807
20705711
20706680
20708634
20733275
20796278
20811623
20832528
20838751
20846452
20868356
20869265
20934533
20938987
21037234
21044950
21079975
21080099
21081499
21091076
21102410
21113640
21136273
21144518
21148661
21157922
21172416
21174817
21191307
21198350
21206978
21211285
21216973
21233593
21236443
21275653
21296438
21307400
21321939
21354100
21366594
21389316
21412259
21425334
21426408
21454555
21495030
21497776
21502755
21506927
21518986
21525764
21531452
21545264
21552291
21555518
21556890
21576421
21598088
21620964
21646819
21647550
21725851
21729576
21737788
21741353
21742584
21756955
21765894
21781496
21808062
21827279
21833623
21861350
21868703
21889036
21898994
21902835
21906983
21911884
21911919
21945498
21963094
21982894
21987660
21988832
21992109
22048453
22078849
22088544
22095074
22123460
22137262
22138245
22142473
22147556
22155307
22158875
22200625
22203790
22212955
22264017
22271370
22276118
22290142
22302482
22323644
22330859
22338608
22418244
22427825
22438807
22461696
22490514
22503972
22541814
22542718
22545110
22549002
22559824
22573121
22578468
22578957
22579918
22580187
22583702
22587389
22594519
22609818
22613607
22630328
22666428
22670665
22682876
22689053
22698995
22750196
22776971
22842631
22843690
22849380
22875919
22879597
22881289
22901690
22939811
22945906
22959128
22966170
22989377
23010497
23046979
23051580
23052192
23055342
23074199
23087099
23090292
23092328
23103292
23114386
23123430
23139759
23150184
23158494
23221079
23226098
23238643
23251661
23255485
23288142
23293173
23324179
23345623
23403148
23403272
23406266
23406650
23412940
23423194
23430116
23437133
23454680
23521418
23526997
23536693
23567851
23569422
23571756
23580430
23583371
23602216
23606537
23615401
23617628
23660665
23665328
23671274
23714423
23716558
23720344
23725037
23728734
23737527
23739547
23792437
23813560
23840483
23893806
23919806
23939757
23981612
24038461
24053646
24075775
24098580
24109237
24180625
24201221
24211270
24226420
24234335
24239896
24300974
24413553
24440642
24553299
24670375
24733848

Gene Ontology  (GO ID)

Biological Process

GO:0001525  angiogenesis
GO:0008219  cell death
GO:0006879  cellular iron ion homeostasis
GO:0071276  cellular response to cadmium ion
GO:0071456  cellular response to hypoxia
GO:0031670  cellular response to nutrient
GO:0008630  DNA damage response, signal transduction resulting in induction of apoptosis
GO:0001935  endothelial cell proliferation
GO:0034101  erythrocyte homeostasis
GO:0007588  excretion
GO:0002246  healing during inflammatory response
GO:0042167  heme catabolic process
GO:0006788  heme oxidation
GO:0055072  iron ion homeostasis
GO:0034383  low-density lipoprotein particle clearance
GO:0043392  negative regulation of DNA binding
GO:0002686  negative regulation of leukocyte migration
GO:0032764  negative regulation of mast cell cytokine production
GO:0043305  negative regulation of mast cell degranulation
GO:0043524  negative regulation of neuron apoptosis
GO:0048662  negative regulation of smooth muscle cell proliferation
GO:0043433  negative regulation of transcription factor activity
GO:0006778  porphyrin metabolic process
GO:0045766  positive regulation of angiogenesis
GO:0045080  positive regulation of chemokine biosynthetic process
GO:0043123  positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0048661  positive regulation of smooth muscle cell proliferation
GO:0045909  positive regulation of vasodilation
GO:0051260  protein homooligomerization
GO:0007243  protein kinase cascade
GO:0045765  regulation of angiogenesis
GO:0008217  regulation of blood pressure
GO:0051090  regulation of transcription factor activity
GO:0043619  regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0043627  response to estrogen stimulus
GO:0042542  response to hydrogen peroxide
GO:0035094  response to nicotine
GO:0006979  response to oxidative stress
GO:0007264  small GTPase mediated signal transduction
GO:0014806  smooth muscle hyperplasia
GO:0055085  transmembrane transport

Cellular Component

GO:0005901  caveola
GO:0005829  cytosol
GO:0005783  endoplasmic reticulum
GO:0005789  endoplasmic reticulum membrane
GO:0005615  extracellular space
GO:0016020  membrane
GO:0005730  nucleolus
GO:0005634  nucleus

Molecular Function

GO:0019899  enzyme binding
GO:0020037  heme binding
GO:0004392  heme oxygenase (decyclizing) activity
GO:0046872  metal ion binding
GO:0004630  phospholipase D activity
GO:0042803  protein homodimerization activity
GO:0004871  signal transducer activity