forkhead box A2

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Synonym

HNF3B, Hepatocyte nuclear factor 3-beta, FOXA2, MGC19807, HNF-3B, forkhead box A2, TCF3B, Forkhead box protein A2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:5.90 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:4.97 cerebellum:4.75 brain stem:5.45 corpus callosum/glia:4.76 pineal gland:- peripheral nerve:4.50 spine:4.71 retina:- eye:- artery/aorta:4.93 vein:5.18 lymphnode:4.54 peripheral blood:- spleen:4.35 thymus:4.15 bone marrow:4.94 adipose:4.98 bone:- skin:5.02
CAGE cerebrum:0 cerebellum:- brain stem:0.03 corpus callosum/glia:0 pineal gland:0 peripheral nerve:- spine:0 retina:- eye:- artery/aorta:0.59 vein:0 lymphnode:0.28 peripheral blood:- spleen:0 thymus:0 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:0.01 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.25 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:4.30 heart:- muscle:- esophagus:- stomach:- intestine:- colon:17     liver/hepato:-        lung:9.80    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:35.60 breast:- salivary:-
GeneChip uterus:5.14 placenta:4.49 prostate:4.49 ovary:5.06 testis:4.74 heart:5.10 muscle:5.11 esophagus:4.71 stomach:7.04 intestine:5.84 colon:6.35 liver/hepato:7.85 lung:5.90 bladder:- kidney:5.01 pituitary:4.71 thyroid/parathyroid:5.02 adrenal gland:4.93 pancreas:6.38 breast:4.49 salivary:5.24
CAGE uterus:1.22 placenta:0.08 prostate:0.33 ovary:1.50 testis:0.04 heart:0 muscle:0.05 esophagus:0 stomach:- intestine:1.02 colon:1.76     liver/hepato:3.79    lung:3.01 bladder:0.09 kidney:0 pituitary:0.10 thyroid/parathyroid:0.82 adrenal gland:- pancreas:3.87 breast:0 salivary:0
RNA-seq uterus:- placenta:- prostate:0 ovary:1.08 testis:0.19 heart:0 muscle:0 esophagus:- stomach:- intestine:- colon:0.26     liver/hepato:3.56        lung:0.82    bladder:- kidney:0.15 pituitary:- thyroid/parathyroid:0.37 adrenal gland:0 pancreas:- breast:0 salivary:-

Gene Information

IDs

Refseq ID NM_153675
Gene ID 3170
Unigene ID Hs.155651
Probe set ID 210103_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000125798
GTEx ID ENSG00000125798

Orthologous Gene

Mouse[1]  NM_010446
Rat [0]  

Chromosomal Region

20p11.21  [22,561,643  -  22,566,093]

Gene Family (Interpro ID)

IPR001766  Transcription factor, fork head
IPR011991  Winged helix repressor DNA-binding

Link to Pubmed  (Pubmed ID)

9119385
9931457
10623575
10672453
10748198
10868948
10899756
11069927
11780052
11875061
12124776
12163409
12477932
12509444
12642491
12911579
14500912
14739090
15123725
15205324
15489334
15737987
16001449
16459311
16675598
16892178
17101796
17283222
17471492
17715393
18381283
18593902
18660816
18666263
18682709
18753309
18797817
18798232
19302415
19589781
19769745
19913121
19934400
20048076
20049900
20074681
20152958
20160041
20357092
20382118
20628086
20820189
20967225
21037926
21292830
21466784
22067325
22196886
22268124
22325233
22341411
22432472
22581228
22693459
22877565
22945641
23236435
23275033
23349771
23391216
24478438

Gene Ontology  (GO ID)

Biological Process

GO:0008344  adult locomotory behavior
GO:0009952  anterior/posterior pattern formation
GO:0060441  branching involved in lung morphogenesis
GO:0021533  cell differentiation in hindbrain
GO:0016568  chromatin modification
GO:0021904  dorsal/ventral neural tube patterning
GO:0001705  ectoderm formation
GO:0031018  endocrine pancreas development
GO:0007492  endoderm development
GO:0001701  in utero embryonic development
GO:0060487  lung epithelial cell differentiation
GO:0032289  myelin formation in the central nervous system
GO:0010719  negative regulation of epithelial to mesenchymal transition
GO:0033132  negative regulation of glucokinase activity
GO:0045665  negative regulation of neuron differentiation
GO:0043433  negative regulation of transcription factor activity
GO:0000433  negative regulation of transcription from RNA polymerase II promoter by glucose
GO:0048665  neuron fate specification
GO:0021779  oligodendrocyte cell fate commitment
GO:0040019  positive regulation of embryonic development
GO:0045666  positive regulation of neuron differentiation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0000432  positive regulation of transcription from RNA polymerase II promoter by glucose
GO:0045945  positive regulation of transcription from RNA polymerase III promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0090009  primitive streak formation
GO:0030193  regulation of blood coagulation
GO:0051090  regulation of transcription factor activity
GO:0006357  regulation of transcription from RNA polymerase II promoter
GO:0070741  response to interleukin-6
GO:0032525  somite rostral/caudal axis specification

Cellular Component

GO:0005737  cytoplasm
GO:0005634  nucleus
GO:0005667  transcription factor complex

Molecular Function

GO:0008301  DNA bending activity
GO:0003677  DNA binding
GO:0044212  DNA regulatory region binding
GO:0003690  double-stranded DNA binding
GO:0019904  protein domain specific binding
GO:0003705  RNA polymerase II transcription factor activity, enhancer binding
GO:0003700  transcription factor activity
GO:0008134  transcription factor binding