histidine-rich glycoprotein

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Synonym

Histidine-rich glycoprotein precursor, DKFZp779H1622, histidine-rich glycoprotein, Histidine-proline-rich glycoprotein, HRGP, HPRG, HRG

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:20.10 cerebellum:25.20 brain stem:- corpus callosum/glia:- pineal gland:445 peripheral nerve:- spine:- retina:- eye:29.40 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:37.80 thymus:12.90 bone marrow:- adipose:40.30 bone:12.80 skin:-
GeneChip cerebrum:5.07 cerebellum:5.26 brain stem:5.11 corpus callosum/glia:4.97 pineal gland:- peripheral nerve:4.88 spine:5.09 retina:- eye:- artery/aorta:4.83 vein:5.36 lymphnode:4.89 peripheral blood:- spleen:4.91 thymus:4.41 bone marrow:5.38 adipose:5.11 bone:- skin:4.84
CAGE cerebrum:0.17 cerebellum:- brain stem:0 corpus callosum/glia:0.07 pineal gland:0 peripheral nerve:- spine:0 retina:- eye:- artery/aorta:0 vein:0 lymphnode:0 peripheral blood:- spleen:0 thymus:0 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:0.10 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.01 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:9.10 placenta:18.20 prostate:11.30 ovary:- testis:21.60 heart:- muscle:20.10 esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:48.90    bladder:- kidney:31.20 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:37.20 salivary:-
GeneChip uterus:4.76 placenta:5.39 prostate:4.47 ovary:4.74 testis:4.75 heart:5.37 muscle:5.54 esophagus:4.83 stomach:5.39 intestine:5.16 colon:5.40 liver/hepato:13.18 lung:4.94 bladder:- kidney:8.32 pituitary:4.86 thyroid/parathyroid:4.82 adrenal gland:5.15 pancreas:5.18 breast:4.80 salivary:5.14
CAGE uterus:0 placenta:0 prostate:0 ovary:0 testis:0.12 heart:0.20 muscle:0.05 esophagus:0 stomach:- intestine:0 colon:0     liver/hepato:8.00    lung:0 bladder:0 kidney:1.91 pituitary:0 thyroid/parathyroid:0.12 adrenal gland:- pancreas:0 breast:0 salivary:0
RNA-seq uterus:- placenta:- prostate:0 ovary:0 testis:0.07 heart:0 muscle:0.01 esophagus:- stomach:- intestine:- colon:0     liver/hepato:8.72        lung:0.01    bladder:- kidney:2.52 pituitary:- thyroid/parathyroid:0.01 adrenal gland:0.01 pancreas:- breast:0 salivary:-

Gene Information

IDs

Refseq ID NM_000412
Gene ID 3273
Unigene ID Hs.149849
Probe set ID 206226_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000113905
GTEx ID ENSG00000113905

Orthologous Gene

Mouse[1]  NM_053176
Rat[1]  NM_133428

Chromosomal Region

3q27.3  [186,378,005  -  186,396,029]

Gene Family (Interpro ID)

IPR000010  Proteinase inhibitor I25, cystatin

Link to Pubmed  (Pubmed ID)

678554
1459097
1561009
1678514
2347592
2524479
2566603
3011081
3819648
3958188
4116337
6414553
6438154
6740558
8188234
8348977
8478589
8478593
9184145
9276466
9414276
10050040
10421785
10514432
11134179
12391183
12477932
12764609
14718574
14744774
15138272
15220341
15269838
15489334
16107330
16335952
16344560
16436387
16489009
17229145
18797515
19056867
19285951
19674792
19712047
19903770
19913121
20071662
20237496
20303064
20573803
20628086
21215706
21304106
21665544
21757718
21988832
22703881
22895448
23576524
23672470

Gene Ontology  (GO ID)

Biological Process

GO:0001525  angiogenesis
GO:0007596  blood coagulation
GO:0006935  chemotaxis
GO:0050832  defense response to fungus
GO:0042730  fibrinolysis
GO:0016525  negative regulation of angiogenesis
GO:0043537  negative regulation of blood vessel endothelial cell migration
GO:0007162  negative regulation of cell adhesion
GO:0033629  negative regulation of cell adhesion mediated by integrin
GO:0030308  negative regulation of cell growth
GO:0008285  negative regulation of cell proliferation
GO:0051918  negative regulation of fibrinolysis
GO:0010593  negative regulation of lamellipodium assembly
GO:0030168  platelet activation
GO:0002576  platelet degranulation
GO:0043065  positive regulation of apoptosis
GO:0051894  positive regulation of focal adhesion formation
GO:0002839  positive regulation of immune response to tumor cell
GO:0032956  regulation of actin cytoskeleton organization
GO:0030193  regulation of blood coagulation
GO:0010468  regulation of gene expression
GO:0050730  regulation of peptidyl-tyrosine phosphorylation
GO:0010543  regulation of platelet activation
GO:0043254  regulation of protein complex assembly

Cellular Component

GO:0005576  extracellular region
GO:0005886  plasma membrane
GO:0031093  platelet alpha granule lumen

Molecular Function

GO:0004869  cysteine-type endopeptidase inhibitor activity
GO:0020037  heme binding
GO:0043395  heparan sulfate proteoglycan binding
GO:0008201  heparin binding
GO:0019865  immunoglobulin binding
GO:0046872  metal ion binding
GO:0005515  protein binding
GO:0004867  serine-type endopeptidase inhibitor activity
GO:0008270  zinc ion binding