hydroxysteroid (11-beta) dehydrogenase 2

Synonym

11-beta-hydroxysteroid dehydrogenase type 2, Corticosteroid 11-beta-dehydrogenase isozyme 2, HSD2, HSD11B2, AME, 11-DH2, NAD-dependent 11-beta-hydroxysteroid dehydrogenase, HSD11K, hydroxysteroid (11-beta) dehydrogenase 2, 11-beta-HSD2, AME1

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:4.70

cerebellum:-

brain stem:-

corpus callosum/glia:29.20

pineal gland:-

peripheral nerve:61.30

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:38.70

bone marrow:-

adipose:-

bone:-

skin:67.20

GeneChip

cerebrum:4.41

cerebellum:4.32

brain stem:4.40

corpus callosum/glia:4.05

pineal gland:-

peripheral nerve:4.12

spine:4.13

retina:-

eye:-

artery/aorta:4.66

vein:4.22

lymphnode:4.29

peripheral blood:-

spleen:4.65

thymus:4.02

bone marrow:4.25

adipose:4.57

bone:-

skin:6.06

CAGE

cerebrum:0.89

cerebellum:-

brain stem:0.60

corpus callosum/glia:0.13

pineal gland:0.14

peripheral nerve:-

spine:0.09

retina:-

eye:-

artery/aorta:0.79

vein:1.53

lymphnode:1.02

peripheral blood:-

spleen:1.21

thymus:0.33

bone marrow:-

adipose:0.26

bone:-

skin:-

RNA-seq

cerebrum:0.48

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0.44

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0.09

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:9.10

placenta:14.60

prostate:11.30

ovary:-

testis:26

heart:12.80

muscle:40.20

esophagus:-

stomach:42.50

intestine:32.40

colon:8.50

liver/hepato:-

lung:14.70

bladder:-

kidney:10.40

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

GeneChip

uterus:5.82

placenta:8.36

prostate:5.59

ovary:4.99

testis:4.53

heart:4.41

muscle:4.64

esophagus:4.83

stomach:4.65

intestine:5.82

colon:8.62

liver/hepato:4.47

lung:4.53

bladder:-

kidney:10.21

pituitary:4.32

thyroid/parathyroid:5.43

adrenal gland:4.73

pancreas:4.69

breast:5.02

salivary:8.80

CAGE

uterus:2.40

placenta:4.51

prostate:2.27

ovary:2.44

testis:1.36

heart:0.32

muscle:0.09

esophagus:1.83

stomach:-

intestine:4.97

colon:5.09

liver/hepato:1.01

lung:1.54

bladder:0.83

kidney:5.60

pituitary:0.10

thyroid/parathyroid:2.14

adrenal gland:-

pancreas:1.59

breast:1.53

salivary:4.85

RNA-seq

uterus:-

placenta:-

prostate:1.02

ovary:2.81

testis:1.90

heart:0.04

muscle:0

esophagus:-

stomach:-

intestine:-

colon:3.49

liver/hepato:1.02

lung:1.33

bladder:-

kidney:6.99

pituitary:-

thyroid/parathyroid:1.63

adrenal gland:1.13

pancreas:-

breast:0.54

salivary:-

IDs

Refseq ID	NM_000196
Gene ID	3291
Unigene ID	Hs.137674
Probe set ID	204130_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000176387
GTEx ID	ENSG00000176387

Orthologous Gene

Mouse[1]	NM_008289
Rat [0]

Chromosomal Region

16q22.1 [67,465,041 - 67,471,456]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR002347	Glucose/ribitol dehydrogenase
IPR002198	Short-chain dehydrogenase/reductase SDR

Gene Ontology (GO ID)

Biological Process

GO:0007565	female pregnancy
GO:0006704	glucocorticoid biosynthetic process
GO:0002017	regulation of blood volume by renal aldosterone
GO:0042493	response to drug
GO:0032094	response to food
GO:0051384	response to glucocorticoid stimulus
GO:0001666	response to hypoxia
GO:0032868	response to insulin stimulus

Cellular Component

GO:0005783

endoplasmic reticulum

Molecular Function

GO:0003845	11-beta-hydroxysteroid dehydrogenase activity
GO:0051287	NAD or NADH binding
GO:0005496	steroid binding

hydroxysteroid (11-beta) dehydrogenase 2

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function