isoleucyl-tRNA synthetase

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Synonym

PRO0785, Isoleucyl-tRNA synthetase, cytoplasmic, FLJ20736, IRS, ILRS, IleRS, isoleucine-tRNA synthetase, Isoleucine--tRNA ligase, IARS

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:216.90 cerebellum:327.40 brain stem:- corpus callosum/glia:291.60 pineal gland:148.30 peripheral nerve:245.40 spine:224.60 retina:118.60 eye:76.40 artery/aorta:- vein:266.60 lymphnode:171.90 peripheral blood:54.70 spleen:- thymus:38.70 bone marrow:196.80 adipose:161.30 bone:153.50 skin:432
GeneChip cerebrum:8.35 cerebellum:8.64 brain stem:8.57 corpus callosum/glia:7.81 pineal gland:- peripheral nerve:8.76 spine:8.06 retina:- eye:- artery/aorta:8.06 vein:8.14 lymphnode:8.47 peripheral blood:- spleen:8.07 thymus:8.62 bone marrow:8.30 adipose:8.29 bone:- skin:8.53
CAGE cerebrum:4.18 cerebellum:- brain stem:4.24 corpus callosum/glia:3.84 pineal gland:4.33 peripheral nerve:- spine:4.13 retina:- eye:- artery/aorta:4.11 vein:3.83 lymphnode:4.17 peripheral blood:- spleen:3.96 thymus:4.00 bone marrow:- adipose:3.92 bone:- skin:-
RNA-seq cerebrum:4.03 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.52 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.82 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:182.30 placenta:102 prostate:22.50 ovary:149.10 testis:341.80 heart:51.10 muscle:60.30 esophagus:- stomach:786 intestine:- colon:169.60     liver/hepato:158.30        lung:205.30    bladder:125.60 kidney:52 pituitary:116 thyroid/parathyroid:- adrenal gland:152.40 pancreas:160 breast:102.20 salivary:-
GeneChip uterus:8.82 placenta:7.41 prostate:8.84 ovary:8.74 testis:8.42 heart:8.46 muscle:8.95 esophagus:8.82 stomach:8.64 intestine:8.70 colon:8.07 liver/hepato:7.83 lung:7.87 bladder:- kidney:8.24 pituitary:8.53 thyroid/parathyroid:8.37 adrenal gland:8.54 pancreas:8.75 breast:8.48 salivary:8.27
CAGE uterus:4.18 placenta:3.54 prostate:3.76 ovary:4.28 testis:3.98 heart:4.13 muscle:4.49 esophagus:3.95 stomach:- intestine:3.43 colon:3.74     liver/hepato:4.17    lung:3.82 bladder:4.00 kidney:3.94 pituitary:4.31 thyroid/parathyroid:4.22 adrenal gland:- pancreas:4.62 breast:4.07 salivary:4.30
RNA-seq uterus:- placenta:- prostate:4.13 ovary:4.93 testis:4.33 heart:3.49 muscle:5.47 esophagus:- stomach:- intestine:- colon:3.84     liver/hepato:3.40        lung:3.42    bladder:- kidney:4.74 pituitary:- thyroid/parathyroid:5.38 adrenal gland:4.41 pancreas:- breast:4.26 salivary:-

Gene Information

IDs

Refseq ID NM_002161
Gene ID 3376
Unigene ID Hs.445403
Probe set ID 204744_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000196305
GTEx ID ENSG00000196305

Orthologous Gene

Mouse[2]  NM_172015
Rat[1]  NM_001100572

Chromosomal Region

9q22.31  [94,972,489  -  95,056,038]

Gene Family (Interpro ID)

IPR018353  Isoleucyl-tRNA synthetase
IPR002301  Isoleucyl-tRNA synthetase, class Ia

Link to Pubmed  (Pubmed ID)

1651330
7721108
8052601
8078941
8188258
8449960
8812440
8816763
9278442
9466989
9556618
9878398
10669760
10913161
11714285
12477932
14702039
15164053
16055448
16196087
16210410
16344560
17353931
18029348
18457437
18541383
18781797
19380743
19615732
19738201
20379614
21081666
21139048
21145461
21319273
21832049
21890473
21906983
21963094
22053931
22190034
22268729
22505724
22623428
22797925
22863883
22939629
23000965
23125841
23349634
23862649
23956138
24639526
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0010467  gene expression
GO:0006428  isoleucyl-tRNA aminoacylation
GO:0006418  tRNA aminoacylation for protein translation

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005730  nucleolus
GO:0005634  nucleus

Molecular Function

GO:0005524  ATP binding
GO:0004822  isoleucine-tRNA ligase activity
GO:0005515  protein binding