inhibitor of DNA binding 3, dominant negative helix-loop-helix protein

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Synonym

ID3, Helix-loop-helix protein HEIR-1, DNA-binding protein inhibitor ID-3, 1R21, ID-like protein inhibitor HLH 1R21, Inhibitor of DNA binding 3, HEIR-1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:43.90 cerebellum:12.60 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:797.50 spine:- retina:118.60 eye:170.40 artery/aorta:30 vein:- lymphnode:30.30 peripheral blood:- spleen:56.70 thymus:12.90 bone marrow:39.40 adipose:40.30 bone:102.40 skin:43.20
GeneChip cerebrum:6.45 cerebellum:5.98 brain stem:6.36 corpus callosum/glia:7.52 pineal gland:- peripheral nerve:8.08 spine:8.04 retina:- eye:- artery/aorta:8.66 vein:8.89 lymphnode:7.34 peripheral blood:- spleen:7.53 thymus:8.18 bone marrow:6.28 adipose:8.13 bone:- skin:7.67
CAGE cerebrum:4.37 cerebellum:- brain stem:4.65 corpus callosum/glia:5.18 pineal gland:4.64 peripheral nerve:- spine:5.16 retina:- eye:- artery/aorta:6.42 vein:5.64 lymphnode:4.89 peripheral blood:- spleen:4.89 thymus:5.20 bone marrow:- adipose:5.36 bone:- skin:-
RNA-seq cerebrum:3.10 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:4.70 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.78 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:63.80 placenta:145.70 prostate:90.10 ovary:409.90 testis:8.70 heart:12.80 muscle:20.10 esophagus:- stomach:212.40 intestine:64.80 colon:50.90     liver/hepato:10.60        lung:68.40    bladder:- kidney:41.60 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:35.60 breast:158 salivary:-
GeneChip uterus:8.24 placenta:8.03 prostate:9.15 ovary:8.55 testis:5.23 heart:8.38 muscle:6.62 esophagus:7.33 stomach:8.16 intestine:7.93 colon:8.87 liver/hepato:6.84 lung:8.72 bladder:- kidney:8.22 pituitary:8.02 thyroid/parathyroid:9.65 adrenal gland:7.37 pancreas:6.68 breast:7.45 salivary:5.93
CAGE uterus:5.54 placenta:5.47 prostate:6.08 ovary:5.46 testis:3.88 heart:5.79 muscle:4.89 esophagus:5.42 stomach:- intestine:5.20 colon:5.45     liver/hepato:4.64    lung:5.55 bladder:5.35 kidney:5.10 pituitary:4.98 thyroid/parathyroid:6.66 adrenal gland:- pancreas:4.27 breast:6.10 salivary:3.82
RNA-seq uterus:- placenta:- prostate:5.93 ovary:5.30 testis:4.64 heart:4.23 muscle:3.50 esophagus:- stomach:- intestine:- colon:4.84     liver/hepato:3.40        lung:5.07    bladder:- kidney:4.70 pituitary:- thyroid/parathyroid:5.40 adrenal gland:6.08 pancreas:- breast:4.56 salivary:-

Gene Information

IDs

Refseq ID NM_002167
Gene ID 3399
Unigene ID Hs.76884
Probe set ID 207826_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000117318
GTEx ID ENSG00000117318

Orthologous Gene

Mouse[1]  NM_008321
Rat [0]  

Chromosomal Region

1p36.12  [23,884,409  -  23,886,285]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

1628620
7777541
7821789
7828896
8437843
8632670
8645731
8759016
8798572
8804437
8999959
9242638
9372912
9525934
9821964
10022839
10585876
10593873
11591653
11756408
11940648
12054881
12477932
12547711
12952978
14627819
15342556
15370294
15451666
15489334
15494533
15583422
15645115
16271072
16449966
16556596
16682435
16710414
17537403
18255255
18281048
18374504
18477564
19054058
19477940
19515385
19948975
20080245
20185798
20191379
20211142
20512523
21030215
21191065
21486943
21498546
21837949
21933340
21963094
21975932
21987572
21993163
22151756
22354994
22505724
22698403
22882857
23060149
23119064
23143595
23311395
23342268
23768125
23771884
24222112
24343358

Gene Ontology  (GO ID)

Biological Process

GO:0007417  central nervous system development
GO:0030855  epithelial cell differentiation
GO:0007507  heart development
GO:0001656  metanephros development
GO:0007275  multicellular organismal development
GO:0007517  muscle organ development
GO:0045668  negative regulation of osteoblast differentiation
GO:0043433  negative regulation of transcription factor activity
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0030182  neuron differentiation
GO:0030903  notochord development
GO:0042476  odontogenesis
GO:0043065  positive regulation of apoptosis
GO:0051726  regulation of cell cycle
GO:0006275  regulation of DNA replication
GO:0009611  response to wounding
GO:0006351  transcription, DNA-dependent

Cellular Component

GO:0005737  cytoplasm
GO:0005634  nucleus

Molecular Function

GO:0046983  protein dimerization activity
GO:0019904  protein domain specific binding
GO:0003714  transcription corepressor activity
GO:0003700  transcription factor activity
GO:0008134  transcription factor binding