isocitrate dehydrogenase 3 (NAD+) alpha

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Synonym

isocitrate dehydrogenase 3 (NAD+) alpha, IDH3A

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:177.80 cerebellum:125.90 brain stem:- corpus callosum/glia:204.10 pineal gland:148.30 peripheral nerve:30.70 spine:224.60 retina:237.30 eye:47 artery/aorta:179.90 vein:133.30 lymphnode:50.60 peripheral blood:36.40 spleen:75.60 thymus:257.70 bone marrow:- adipose:242 bone:25.60 skin:153.60
GeneChip cerebrum:6.49 cerebellum:6.52 brain stem:6.79 corpus callosum/glia:5.88 pineal gland:- peripheral nerve:6.54 spine:6.13 retina:- eye:- artery/aorta:6.04 vein:6.70 lymphnode:5.82 peripheral blood:- spleen:5.69 thymus:7.51 bone marrow:4.79 adipose:6.33 bone:- skin:5.85
CAGE cerebrum:4.30 cerebellum:- brain stem:4.36 corpus callosum/glia:3.81 pineal gland:4.01 peripheral nerve:- spine:3.89 retina:- eye:- artery/aorta:3.40 vein:3.48 lymphnode:3.31 peripheral blood:- spleen:3.29 thymus:3.93 bone marrow:- adipose:3.55 bone:- skin:-
RNA-seq cerebrum:5.91 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:4.23 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.39 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:136.70 placenta:87.40 prostate:135.20 ovary:- testis:86.50 heart:140.50 muscle:20.10 esophagus:- stomach:42.50 intestine:194.40 colon:195     liver/hepato:21.10        lung:48.90    bladder:251.20 kidney:72.80 pituitary:- thyroid/parathyroid:- adrenal gland:304.70 pancreas:17.80 breast:55.80 salivary:328.40
GeneChip uterus:6.26 placenta:6.53 prostate:6.67 ovary:6.10 testis:6.88 heart:7.56 muscle:7.38 esophagus:6.74 stomach:5.80 intestine:6.93 colon:6.23 liver/hepato:5.16 lung:5.61 bladder:- kidney:5.60 pituitary:5.97 thyroid/parathyroid:5 adrenal gland:6.48 pancreas:5.39 breast:5.58 salivary:5.65
CAGE uterus:3.20 placenta:3.26 prostate:3.44 ovary:3.13 testis:3.66 heart:4.37 muscle:4.56 esophagus:3.58 stomach:- intestine:4.37 colon:3.70     liver/hepato:3.50    lung:3.16 bladder:3.59 kidney:3.98 pituitary:3.86 thyroid/parathyroid:3.29 adrenal gland:- pancreas:3.20 breast:3.47 salivary:3.75
RNA-seq uterus:- placenta:- prostate:4.51 ovary:4.56 testis:4.77 heart:6.44 muscle:5.36 esophagus:- stomach:- intestine:- colon:4.47     liver/hepato:4.08        lung:4.63    bladder:- kidney:5.44 pituitary:- thyroid/parathyroid:5.37 adrenal gland:4.55 pancreas:- breast:4.86 salivary:-

Gene Information

IDs

Refseq ID NM_005530
Gene ID 3419
Unigene ID Hs.591110
Probe set ID 202069_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000166411
GTEx ID ENSG00000166411

Orthologous Gene

Mouse[3]  NM_029573
Rat[1]  NM_053638

Chromosomal Region

15q25.1  [78,441,663  -  78,464,291]

Gene Family (Interpro ID)

IPR004434  Isocitrate dehydrogenase NAD-dependent, mitochondrial
IPR001804  Isocitrate/isopropylmalate dehydrogenase

Link to Pubmed  (Pubmed ID)

7755589
8125298
8833160
10601238
10677231
12477932
12488461
12543931
12601813
14555658
14702039
15489334
16236267
16737955
17314511
17432878
18029348
18457437
19615732
20306291
20562859
20811636
20877624
21139048
21890473
21906983
21963094
21988832
22190034
22939629
23125841
23798571
24583282
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0005975  carbohydrate metabolic process
GO:0044237  cellular metabolic process
GO:0006099  tricarboxylic acid cycle

Cellular Component

GO:0005759  mitochondrial matrix
GO:0005739  mitochondrion

Molecular Function

GO:0004449  isocitrate dehydrogenase (NAD+) activity
GO:0000287  magnesium ion binding
GO:0051287  NAD or NADH binding