apolipoprotein C-II

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Synonym

Apo-CII, apolipoprotein C-II, MGC75082, APOC2, Apolipoprotein C-II precursor, ApoC-II

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:4.70 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:29.40 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:113.40 thymus:- bone marrow:- adipose:- bone:- skin:4.80
GeneChip cerebrum:6.74 cerebellum:5.90 brain stem:7.08 corpus callosum/glia:7.08 pineal gland:- peripheral nerve:6.67 spine:7.26 retina:- eye:- artery/aorta:6.19 vein:5.66 lymphnode:5.66 peripheral blood:- spleen:5.40 thymus:5.34 bone marrow:5.91 adipose:6.07 bone:- skin:6.08
CAGE cerebrum:2.90 cerebellum:- brain stem:3.25 corpus callosum/glia:3.55 pineal gland:1.58 peripheral nerve:- spine:3.79 retina:- eye:- artery/aorta:1.10 vein:0.47 lymphnode:1.50 peripheral blood:- spleen:0.45 thymus:0.50 bone marrow:- adipose:1.12 bone:- skin:-
RNA-seq cerebrum:3.21 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.03 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.02 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:3.60 prostate:11.30 ovary:- testis:- heart:25.50 muscle:20.10 esophagus:- stomach:- intestine:- colon:8.50     liver/hepato:274.40        lung:44    bladder:- kidney:72.80 pituitary:116 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:5.65 placenta:6.05 prostate:5.52 ovary:5.96 testis:5.48 heart:5.94 muscle:5.76 esophagus:5.92 stomach:6.18 intestine:6.99 colon:6.22 liver/hepato:11.69 lung:7.06 bladder:- kidney:6.35 pituitary:6 thyroid/parathyroid:5.58 adrenal gland:6.28 pancreas:6.65 breast:5.75 salivary:5.87
CAGE uterus:0.35 placenta:0.68 prostate:1.28 ovary:0.47 testis:0.79 heart:0.27 muscle:0.17 esophagus:0.18 stomach:- intestine:4.08 colon:2.26     liver/hepato:7.90    lung:2.84 bladder:0.26 kidney:1.32 pituitary:1.17 thyroid/parathyroid:0.76 adrenal gland:- pancreas:0 breast:1.16 salivary:0.62
RNA-seq uterus:- placenta:- prostate:1.06 ovary:0.71 testis:0.38 heart:0.23 muscle:0 esophagus:- stomach:- intestine:- colon:0.50     liver/hepato:11.25        lung:2.34    bladder:- kidney:0.94 pituitary:- thyroid/parathyroid:0.04 adrenal gland:0.29 pancreas:- breast:0.70 salivary:-

Gene Information

IDs

Refseq ID NM_000483
Gene ID 344
Unigene ID Hs.75615
Probe set ID 204561_x_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000224916
ENSG00000234906
GTEx ID ENSG00000224916
ENSG00000234906

Orthologous Gene

Mouse[2]  NM_009695, NM_007385
Rat[2]  NM_001085352, NM_001109419

Chromosomal Region

19q13.32  [45,449,243  -  45,452,814]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

182536
194244
1555583
1782747
1917954
1971748
2209608
2415514
2477392
3014272
3030808
3192518
3263393
3467353
3474626
3525527
3558370
3680515
3944267
3944271
4020294
4345202
6328445
6328478
6546757
6593704
6706938
7815420
7923858
8112221
8245722
8323539
8490626
8530039
10391210
10727238
11162594
11310852
11579204
11751863
11752456
11930616
12032151
12220441
12450397
12477932
12590574
12682050
12782148
12783430
14718574
14746139
15031287
15174051
15489334
15778093
15878877
16432277
16459141
16682745
16763159
16968945
17018885
17174330
17222387
17336988
17429947
17717288
17855807
18005990
18193044
18206908
18660489
18802019
18852267
19014618
19034041
19060906
19197348
19336370
19336475
19534808
19878569
19913121
19948975
20031551
20042600
20331378
20430392
20498921
20571754
20628086
20634891
20686565
20714348
20864672
20972250
21146539
21321243
21476595
21943158
21985034
22239554
22244853
22286219
22808166
23631828

Gene Ontology  (GO ID)

Biological Process

GO:0033344  cholesterol efflux
GO:0042632  cholesterol homeostasis
GO:0034382  chylomicron remnant clearance
GO:0034371  chylomicron remodeling
GO:0034384  high-density lipoprotein particle clearance
GO:0016042  lipid catabolic process
GO:0042157  lipoprotein metabolic process
GO:0042953  lipoprotein transport
GO:0032375  negative regulation of cholesterol transport
GO:0045833  negative regulation of lipid metabolic process
GO:0048261  negative regulation of receptor-mediated endocytosis
GO:0010916  negative regulation of very-low-density lipoprotein particle clearance
GO:0033700  phospholipid efflux
GO:0007603  phototransduction, visible light
GO:0045723  positive regulation of fatty acid biosynthetic process
GO:0051006  positive regulation of lipoprotein lipase activity
GO:0010518  positive regulation of phospholipase activity
GO:0060697  positive regulation of phospholipid catabolic process
GO:0010898  positive regulation of triglyceride catabolic process
GO:0010902  positive regulation of very-low-density lipoprotein particle remodeling
GO:0042493  response to drug
GO:0001523  retinoid metabolic process
GO:0043691  reverse cholesterol transport
GO:0070328  triglyceride homeostasis
GO:0034370  triglyceride-rich lipoprotein particle remodeling
GO:0034372  very-low-density lipoprotein particle remodeling

Cellular Component

GO:0042627  chylomicron
GO:0005769  early endosome
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0034363  intermediate-density lipoprotein particle
GO:0034362  low-density lipoprotein particle
GO:0034366  spherical high-density lipoprotein particle
GO:0034361  very-low-density lipoprotein particle

Molecular Function

GO:0055102  lipase inhibitor activity
GO:0008289  lipid binding
GO:0060230  lipoprotein lipase activator activity
GO:0016004  phospholipase activator activity
GO:0043274  phospholipase binding
GO:0042803  protein homodimerization activity