insulin-like growth factor 1 (somatomedin C)

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Synonym

-

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:8.30 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:398.70 spine:- retina:- eye:29.40 artery/aorta:30 vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:80.70 bone:25.60 skin:4.80
GeneChip cerebrum:4.44 cerebellum:3.73 brain stem:4.33 corpus callosum/glia:4.04 pineal gland:- peripheral nerve:5.04 spine:4.34 retina:- eye:- artery/aorta:6.26 vein:7.11 lymphnode:5.16 peripheral blood:- spleen:5.52 thymus:4.71 bone marrow:4.62 adipose:7.98 bone:- skin:5.90
CAGE cerebrum:1.32 cerebellum:- brain stem:1.63 corpus callosum/glia:1.59 pineal gland:0.35 peripheral nerve:- spine:1.63 retina:- eye:- artery/aorta:3.49 vein:3.71 lymphnode:3.13 peripheral blood:- spleen:2.96 thymus:1.88 bone marrow:- adipose:4.67 bone:- skin:-
RNA-seq cerebrum:0.08 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.01 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.12 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:100.20 placenta:32.80 prostate:225.30 ovary:372.60 testis:17.30 heart:102.20 muscle:- esophagus:342.80 stomach:- intestine:97.20 colon:25.40     liver/hepato:31.70        lung:29.30    bladder:- kidney:20.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:53.30 breast:27.90 salivary:-
GeneChip uterus:9.23 placenta:6.98 prostate:7.66 ovary:7.49 testis:6.04 heart:7.14 muscle:5.68 esophagus:5.16 stomach:5.68 intestine:6.37 colon:5.89 liver/hepato:7.61 lung:5.23 bladder:- kidney:4.09 pituitary:3.84 thyroid/parathyroid:5.74 adrenal gland:5.57 pancreas:5.47 breast:7.83 salivary:5.31
CAGE uterus:5.11 placenta:3.87 prostate:5.42 ovary:4.19 testis:4.13 heart:4.06 muscle:3.34 esophagus:4.11 stomach:- intestine:2.34 colon:2.85     liver/hepato:4.38    lung:2.92 bladder:4.42 kidney:2.77 pituitary:1.11 thyroid/parathyroid:4.62 adrenal gland:- pancreas:2.54 breast:3.95 salivary:2.26
RNA-seq uterus:- placenta:- prostate:2.73 ovary:1.74 testis:4.04 heart:1.49 muscle:0.97 esophagus:- stomach:- intestine:- colon:2.85     liver/hepato:2.35        lung:0.78    bladder:- kidney:0.63 pituitary:- thyroid/parathyroid:2.34 adrenal gland:1.56 pancreas:- breast:3.76 salivary:-

IDs

Refseq ID NM_000618
Gene ID 3479
Unigene ID Hs.160562
Probe set ID 209541_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000017427
GTEx ID ENSG00000017427

Orthologous Gene

Mouse[13]  NM_001111274, NM_001111275, NM_001111276, NM_010512, NM_184052
Rat[12]  NM_001082477, NM_001082478, NM_001082479, NM_178866, NM_184052

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

632300
1147105
1319992
1370435
1372070
1383255
1733942
1791841
1852007
2018498
2036417
2082190
2752154
2935423
2937782
2982726
3002851
3242681
3455760
3683205
4550398
6189745
6358902
6382022
7188854
7511544
7683646
7688386
7692086
7720641
7782332
7916968
8421089
8452530
8495408
8857020
8939990
9138096
9446566
9453236
9497324
9681507
9722506
9722589
9831081
9853872
9857239
10084601
10191278
10205209
10226805
10350456
10381171
10391209
10407151
10448861
10459853
10512690
10644978
10749889
10766744
10823924
10848592
11063745
11161840
11175789
11246885
11319179
11344214
11600567
11735247
11749962
11762714
11768601
11787050
11822578
11825899
11834727
11857446
11858767
11867942
11877395
11877670
11896491
11897674
11903419
11904589
11907830
11909998
11914023
11914026
11924928
11937187
11943599
11953210
11964397
11972897
11988840
11994280
11994678
12005306
12006706
12011046
12011225
12032677
12050240
12062094
12070137
12086966
12095637
12102164
12111701
12115549
12122101
12127559
12135130
12135360
12164325
12175483
12186542
12201212
12213898
12217887
12218293
12236578
12237896
12240900
12356750
12364325
12381752
12388463
12389335
12394769
12397390
12419777
12424437
12477932
12508915
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12508940
12509920
12511011
12519841
12545204
12555073
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12571183
12590635
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12592062
12610514
12612059
12631341
12642873
12679458
12714114
12716804
12716855
12716875
12727948
12729801
12730416
12732844
12734180
12735930
12746292
12746903
12759337
12787886
12791939
12800944
12810534
12842994
12843178
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12843187
12858577
12861174
12865482
12867429
12870155
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12960100
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14504195
14521955
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14647921
14657423
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14973173
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15044591
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15067513
15072640
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15087580
15090033
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15105834
15134305
15135045
15140223
15181035
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15205474
15210945
15211595
15217931
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15247132
15254679
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15256976
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15350139
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15986122
16000303
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16015705
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16044163
16051222
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17827385
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17888024
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18003755
18006148
18006928
18022169
18026134
18031946
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18054929
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18067523
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18163429
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18188667
18199422
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18215180
18215216
18236213
18237549
18246120
18250100
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18283040
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18299470
18301972
18308828
18311789
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18316725
18317720
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18365879
18372285
18375957
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18398029
18401200
18403642
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18413316
18420583
18432248
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18451573
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19833751
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20002733
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20010501
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20031461
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20157552
20163445
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Gene Ontology  (GO ID)

Biological Process

GO:0007596  blood coagulation
GO:0001974  blood vessel remodeling
GO:0048754  branching morphogenesis of a tube
GO:0006928  cellular component movement
GO:0044267  cellular protein metabolic process
GO:0050650  chondroitin sulfate proteoglycan biosynthetic process
GO:0006260  DNA replication
GO:0031017  exocrine pancreas development
GO:0010001  glial cell differentiation
GO:0009441  glycolate metabolic process
GO:0048839  inner ear development
GO:0048009  insulin-like growth factor receptor signaling pathway
GO:0048286  lung alveolus development
GO:0060463  lung lobe morphogenesis
GO:0060426  lung vasculature development
GO:0030879  mammary gland development
GO:0035264  multicellular organism growth
GO:0014896  muscle hypertrophy
GO:0007517  muscle organ development
GO:0045445  myoblast differentiation
GO:0051450  myoblast proliferation
GO:0014904  myotube cell development
GO:0060766  negative regulation of androgen receptor signaling pathway
GO:0008285  negative regulation of cell proliferation
GO:0070373  negative regulation of ERK1 and ERK2 cascade
GO:0090201  negative regulation of release of cytochrome c from mitochondria
GO:0034392  negative regulation of smooth muscle cell apoptosis
GO:0048015  phosphoinositide-mediated signaling
GO:0030168  platelet activation
GO:0002576  platelet degranulation
GO:0042104  positive regulation of activated T cell proliferation
GO:0070886  positive regulation of calcineurin-NFAT signaling pathway
GO:0010613  positive regulation of cardiac muscle hypertrophy
GO:0008284  positive regulation of cell proliferation
GO:0043388  positive regulation of DNA binding
GO:0045740  positive regulation of DNA replication
GO:0050679  positive regulation of epithelial cell proliferation
GO:0048146  positive regulation of fibroblast proliferation
GO:0046326  positive regulation of glucose import
GO:0045725  positive regulation of glycogen biosynthetic process
GO:0045821  positive regulation of glycolysis
GO:0021940  positive regulation of granule cell precursor proliferation
GO:0043568  positive regulation of insulin-like growth factor receptor signaling pathway
GO:0043410  positive regulation of MAPKKK cascade
GO:0045840  positive regulation of mitosis
GO:0045669  positive regulation of osteoblast differentiation
GO:0050731  positive regulation of peptidyl-tyrosine phosphorylation
GO:0014068  positive regulation of phosphoinositide 3-kinase cascade
GO:0033160  positive regulation of protein import into nucleus, translocation
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0046579  positive regulation of Ras protein signal transduction
GO:0014911  positive regulation of smooth muscle cell migration
GO:0048661  positive regulation of smooth muscle cell proliferation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0042523  positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0060527  prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060736  prostate gland growth
GO:0060741  prostate gland stromal morphogenesis
GO:0030166  proteoglycan biosynthetic process
GO:0007265  Ras protein signal transduction
GO:0032878  regulation of establishment or maintenance of cell polarity
GO:0040014  regulation of multicellular organism growth
GO:0014834  satellite cell maintenance involved in skeletal muscle regeneration
GO:0007165  signal transduction
GO:0001501  skeletal system development
GO:0060509  Type I pneumocyte differentiation
GO:0060510  Type II pneumocyte differentiation
GO:0030104  water homeostasis

Cellular Component

GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0016942  insulin-like growth factor binding protein complex
GO:0005886  plasma membrane
GO:0031093  platelet alpha granule lumen

Molecular Function

GO:0008083  growth factor activity
GO:0005179  hormone activity
GO:0005158  insulin receptor binding
GO:0005159  insulin-like growth factor receptor binding
GO:0005178  integrin binding
GO:0005515  protein binding