interleukin 4

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Synonym

Binetrakin, Pitrakinra, interleukin 4, IL4, Lymphocyte stimulatory factor 1, BSF1, Interleukin-4 precursor, BSF-1, IL-4, B-cell stimulatory factor 1, MGC79402

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:18.20 spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:3.14 cerebellum:3.20 brain stem:3.17 corpus callosum/glia:3.10 pineal gland:- peripheral nerve:3.07 spine:3.04 retina:- eye:- artery/aorta:3.20 vein:3.20 lymphnode:3.18 peripheral blood:- spleen:2.94 thymus:3.06 bone marrow:3.31 adipose:3.19 bone:- skin:3.36
CAGE cerebrum:0 cerebellum:- brain stem:0 corpus callosum/glia:0 pineal gland:0 peripheral nerve:- spine:0 retina:- eye:- artery/aorta:0 vein:0 lymphnode:0 peripheral blood:- spleen:0 thymus:0.06 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:0 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.00 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:2.95 placenta:3.09 prostate:2.88 ovary:3.03 testis:2.97 heart:3.08 muscle:3.26 esophagus:3.02 stomach:2.98 intestine:3.02 colon:3.12 liver/hepato:3.08 lung:3.18 bladder:- kidney:2.99 pituitary:3.09 thyroid/parathyroid:2.99 adrenal gland:3.06 pancreas:3.43 breast:2.93 salivary:3.07
CAGE uterus:0 placenta:0 prostate:0 ovary:0 testis:0 heart:0 muscle:0 esophagus:0 stomach:- intestine:0 colon:0     liver/hepato:0    lung:0.17 bladder:0 kidney:0 pituitary:0 thyroid/parathyroid:0 adrenal gland:- pancreas:0 breast:0 salivary:0
RNA-seq uterus:- placenta:- prostate:0 ovary:0.00 testis:0.00 heart:0 muscle:0 esophagus:- stomach:- intestine:- colon:0     liver/hepato:0        lung:0.00    bladder:- kidney:0 pituitary:- thyroid/parathyroid:0 adrenal gland:0 pancreas:- breast:0 salivary:-

IDs

Refseq ID NM_000589
Gene ID 3565
Unigene ID Hs.73917
Probe set ID 207539_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000113520
GTEx ID ENSG00000113520

Orthologous Gene

Mouse[1]  NM_021283
Rat [0]  

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

1197194
1346976
1400355
1511746
1567880
1567881
1569578
1609277
1932028
1946344
1993171
2535858
3016727
3257560
7523014
7589092
7664036
7695626
7806280
7963560
8151703
8266078
8516290
8602263
8603435
8609418
8764000
9113989
9130521
9130652
9334723
9799097
9856950
10219247
10438901
10473513
10623799
10710213
10714547
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10853974
11023480
11035134
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11233912
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11315919
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19408823
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19470040
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19804407
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20121760
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Gene Ontology  (GO ID)

Biological Process

GO:0031296  B cell costimulation
GO:0030183  B cell differentiation
GO:0006968  cellular defense response
GO:0071288  cellular response to mercury ion
GO:0006935  chemotaxis
GO:0008203  cholesterol metabolic process
GO:0045189  connective tissue growth factor biosynthetic process
GO:0042832  defense response to protozoan
GO:0007565  female pregnancy
GO:0006955  immune response
GO:0002227  innate immune response in mucosa
GO:0002674  negative regulation of acute inflammatory response
GO:0043066  negative regulation of apoptosis
GO:0002677  negative regulation of chronic inflammatory response
GO:0043031  negative regulation of macrophage activation
GO:0045019  negative regulation of nitric oxide biosynthetic process
GO:0045671  negative regulation of osteoclast differentiation
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0042104  positive regulation of activated T cell proliferation
GO:0030890  positive regulation of B cell proliferation
GO:0045080  positive regulation of chemokine biosynthetic process
GO:0032733  positive regulation of interleukin-10 production
GO:0032736  positive regulation of interleukin-13 production
GO:0048295  positive regulation of isotype switching to IgE isotypes
GO:0048304  positive regulation of isotype switching to IgG isotypes
GO:0045348  positive regulation of MHC class II biosynthetic process
GO:0045582  positive regulation of T cell differentiation
GO:0042102  positive regulation of T cell proliferation
GO:0051091  positive regulation of transcription factor activity
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0042523  positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0050776  regulation of immune response
GO:0045191  regulation of isotype switching
GO:0042325  regulation of phosphorylation
GO:0010155  regulation of proton transport
GO:0034097  response to cytokine stimulus
GO:0042493  response to drug
GO:0045471  response to ethanol
GO:0007584  response to nutrient
GO:0014070  response to organic cyclic substance
GO:0002296  T-helper 1 cell lineage commitment
GO:0045064  T-helper 2 cell differentiation
GO:0042092  T-helper 2 type immune response

Cellular Component

GO:0009897  external side of plasma membrane
GO:0005615  extracellular space

Molecular Function

GO:0005125  cytokine activity
GO:0008083  growth factor activity
GO:0005136  interleukin-4 receptor binding
GO:0005515  protein binding