interleukin 6 receptor

Synonym

MGC104991, IL-6R-alpha, IL6RA, IL6R, CD126 antigen, CD126, IL-6R 1, gp80, IL-6R-1, Interleukin-6 receptor alpha chain precursor, interleukin 6 receptor, Membrane glycoprotein 80

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

nodata

GeneChip

cerebrum:4.77

cerebellum:3.81

brain stem:4.89

corpus callosum/glia:5.30

pineal gland:-

peripheral nerve:5.76

spine:5.68

retina:-

eye:-

artery/aorta:5.87

vein:6.08

lymphnode:7.73

peripheral blood:-

spleen:7.49

thymus:5.52

bone marrow:7.56

adipose:6.02

bone:-

skin:6.15

CAGE

cerebrum:2.04

cerebellum:-

brain stem:2.59

corpus callosum/glia:2.43

pineal gland:1.73

peripheral nerve:-

spine:2.49

retina:-

eye:-

artery/aorta:2.41

vein:3.11

lymphnode:3.33

peripheral blood:-

spleen:2.86

thymus:2.14

bone marrow:-

adipose:2.93

bone:-

skin:-

RNA-seq

cerebrum:1.15

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:2.20

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:1.83

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

nodata

GeneChip

uterus:5.69

placenta:4.58

prostate:5.74

ovary:5.99

testis:4.71

heart:5.60

muscle:5.71

esophagus:5.92

stomach:6.40

intestine:5.37

colon:6.22

liver/hepato:9.58

lung:7.16

bladder:-

kidney:6.34

pituitary:5.76

thyroid/parathyroid:4.86

adrenal gland:6.10

pancreas:4.39

breast:6.28

salivary:4.49

CAGE

uterus:2.65

placenta:1.84

prostate:2.36

ovary:2.42

testis:2.21

heart:2.16

muscle:4.59

esophagus:2.48

stomach:-

intestine:3.25

colon:3.45

liver/hepato:4.19

lung:3.69

bladder:2.58

kidney:2.57

pituitary:2.41

thyroid/parathyroid:1.65

adrenal gland:-

pancreas:2.26

breast:2.69

salivary:1.00

RNA-seq

uterus:-

placenta:-

prostate:0.00

ovary:1.20

testis:1.01

heart:0.00

muscle:0.00

esophagus:-

stomach:-

intestine:-

colon:0.81

liver/hepato:1.93

lung:1.54

bladder:-

kidney:0.86

pituitary:-

thyroid/parathyroid:0.50

adrenal gland:0.63

pancreas:-

breast:0.80

salivary:-

IDs

Refseq ID	NM_181359
Gene ID	3570
Unigene ID	-
Probe set ID	205945_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000160712
GTEx ID	ENSG00000160712

Orthologous Gene

Mouse[2]	NM_010559
Rat [0]

Chromosomal Region

1q21.3 [154,377,669 - 154,441,926]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR003961	Fibronectin, type III
IPR008957	Fibronectin, type III-like fold

Gene Ontology (GO ID)

Biological Process

GO:0006953	acute-phase response
GO:0070120	ciliary neurotrophic factor-mediated signaling pathway
GO:0019221	cytokine-mediated signaling pathway
GO:0050829	defense response to Gram-negative bacterium
GO:0050830	defense response to Gram-positive bacterium
GO:0031018	endocrine pancreas development
GO:0002384	hepatic immune response
GO:0070102	interleukin-6-mediated signaling pathway
GO:0002548	monocyte chemotaxis
GO:0032966	negative regulation of collagen biosynthetic process
GO:0032717	negative regulation of interleukin-8 production
GO:0002446	neutrophil mediated immunity
GO:0010536	positive regulation of activation of Janus kinase activity
GO:0008284	positive regulation of cell proliferation
GO:0032722	positive regulation of chemokine production
GO:0032755	positive regulation of interleukin-6 production
GO:0002690	positive regulation of leukocyte chemotaxis
GO:0043410	positive regulation of MAPKKK cascade
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0045669	positive regulation of osteoblast differentiation
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0034097	response to cytokine stimulus

Cellular Component

GO:0016324	apical plasma membrane
GO:0016323	basolateral plasma membrane
GO:0009986	cell surface
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005896	interleukin-6 receptor complex
GO:0005886	plasma membrane

Molecular Function

GO:0070119	ciliary neurotrophic factor binding
GO:0004897	ciliary neurotrophic factor receptor activity
GO:0019899	enzyme binding
GO:0019981	interleukin-6 binding
GO:0004915	interleukin-6 receptor activity
GO:0005138	interleukin-6 receptor binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

interleukin 6 receptor

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function