interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)

jump to detail

Synonym

IL12B, IL-12B, NKSF2, NK cell stimulatory factor chain 2, CLMF2, IL-12 p40, Interleukin-12 beta chain precursor, CLMF, NKSF, CLMF p40

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:2.62 cerebellum:2.65 brain stem:2.66 corpus callosum/glia:2.74 pineal gland:- peripheral nerve:2.68 spine:2.59 retina:- eye:- artery/aorta:2.65 vein:2.65 lymphnode:2.73 peripheral blood:- spleen:2.67 thymus:2.88 bone marrow:2.70 adipose:2.63 bone:- skin:2.61
CAGE cerebrum:0 cerebellum:- brain stem:0 corpus callosum/glia:0 pineal gland:0 peripheral nerve:- spine:0 retina:- eye:- artery/aorta:0 vein:0 lymphnode:0.03 peripheral blood:- spleen:0 thymus:0.99 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:0.01 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:2.61 placenta:2.93 prostate:2.49 ovary:2.61 testis:2.54 heart:2.69 muscle:2.63 esophagus:2.53 stomach:2.60 intestine:2.60 colon:2.64 liver/hepato:2.55 lung:2.65 bladder:- kidney:2.54 pituitary:2.55 thyroid/parathyroid:2.63 adrenal gland:2.51 pancreas:2.63 breast:2.67 salivary:2.56
CAGE uterus:0 placenta:0 prostate:0 ovary:0 testis:0 heart:0 muscle:0 esophagus:0 stomach:- intestine:0 colon:0     liver/hepato:0    lung:0 bladder:0 kidney:0 pituitary:0 thyroid/parathyroid:0 adrenal gland:- pancreas:0 breast:0 salivary:0
RNA-seq uterus:- placenta:- prostate:0 ovary:0 testis:0.08 heart:0 muscle:0 esophagus:- stomach:- intestine:- colon:0     liver/hepato:0        lung:0.08    bladder:- kidney:0.02 pituitary:- thyroid/parathyroid:0 adrenal gland:0.03 pancreas:- breast:0.03 salivary:-

IDs

Refseq ID NM_002187
Gene ID 3593
Unigene ID -
Probe set ID 207901_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000113302
GTEx ID ENSG00000113302

Orthologous Gene

Mouse[2]  NM_008352
Rat [0]  

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

1358798
1673147
1674604
2070420
2204066
7527439
7527811
7565674
7695626
7698768
7836910
7843232
7867080
7903063
8551218
8648753
8760829
8799158
8992506
9108403
9158092
9225992
9516412
9603732
9603733
9671213
9700192
9712080
9789052
9854038
10207176
10320373
10352291
10419056
10890924
10899108
11023671
11087201
11110796
11114383
11196715
11197695
11751963
11753820
11813133
11820460
11940489
11972887
11978670
12023369
12065887
12086971
12100467
12117904
12117918
12202149
12207325
12241719
12270766
12297341
12370346
12413772
12421946
12424624
12424627
12472178
12477932
12542496
12672403
12719551
12857749
12876411
12914676
14551880
14597672
14675396
14679201
14746806
14764743
14962816
14976188
15004750
15007350
15057902
15102082
15114670
15265908
15285014
15295696
15322986
15331709
15356557
15448160
15464247
15482860
15483662
15489334
15523691
15603869
15620465
15644581
15837792
15858599
15869883
15871664
15937086
15941730
15988104
15993716
16005098
16039994
16100774
16210052
16216674
16482511
16514412
16574246
16600026
16637265
16681592
16712658
16750991
16751425
16772281
16789008
16942485
16948912
16966828
17077296
17148969
17152005
17172248
17207965
17236132
17327408
17388919
17392024
17403771
17431094
17445208
17477815
17504509
17509455
17513774
17554261
17564777
17567674
17579859
17587057
17644387
17653830
17703412
17846855
17881511
17888176
17889143
17901940
17932439
17945537
17993580
17994425
18034172
18048021
18075513
18082575
18086266
18092318
18163209
18190588
18192685
18219280
18240960
18300039
18319400
18341612
18367309
18369459
18383521
18389618
18413324
18422730
18438406
18449199
18485489
18497679
18512797
18522869
18557702
18563338
18587394
18588591
18606709
18619507
18628242
18631256
18632587
18633131
18675459
18676680
18680750
18703108
18717726
18800148
18821674
18827961
18834321
19012493
19013323
19035472
19088061
19118071
19134014
19169254
19169255
19170196
19174780
19185507
19210338
19234184
19247692
19249008
19258635
19258923
19262574
19264456
19274925
19279357
19328947
19342681
19419334
19422935
19435421
19487916
19495883
19505916
19516896
19525409
19554267
19573080
19625176
19646340
19683555
19692168
19705136
19733878
19760754
19773279
19773451
19782084
19819209
19832040
19838195
19860911
19861958
19913121
19956104
20003322
20012528
20014019
20016509
20027321
20054003
20060272
20061784
20105444
20145925
20217072
20236616
20237496
20331378
20349123
20350312
20371868
20372811
20387064
20395963
20399512
20416077
20452482
20453000
20483637
20485444
20503287
20521253
20525402
20530519
20544370
20551083
20568250
20570966
20621951
20628086
20653817
20653995
20658240
20673868
20705102
20711808
20714168
20716621
20802378
20811626
20875078
20875477
20953186
20953188
20953190
21055733
21072187
21102463
21145044
21196650
21198744
21208785
21278068
21297633
21310195
21321105
21339808
21351215
21397857
21443923
21470215
21513752
21567173
21623733
21637332
21641076
21689404
21733366
21743469
21747388
21753150
21796650
21819616
21833088
21878338
21972680
22005588
22011063
22045842
22070668
22144535
22190364
22194214
22296201
22327783
22383962
22384203
22479607
22503230
22581790
22614250
22621617
22655069
22656398
22702905
22739501
22740240
22819329
22863216
22897389
22930279
22940148
23006423
23028907
23053983
23065198
23065210
23071313
23093722
23099807
23103228
23128233
23137633
23154183
23240095
23285955
23297015
23297419
23376980
23403235
23429356
23441821
23527200
23573954
23575353
23578145
23600862
23621408
23665963
23679818
23717436
23734222
23755218
23817431
23830516
23844553
23901045
23955419
23991654
24051922
24073214
24127073
24158609
24654313

Gene Ontology  (GO ID)

Biological Process

GO:0007050  cell cycle arrest
GO:0016477  cell migration
GO:0071346  cellular response to interferon-gamma
GO:0071222  cellular response to lipopolysaccharide
GO:0050829  defense response to Gram-negative bacterium
GO:0042832  defense response to protozoan
GO:0051607  defense response to virus
GO:0042095  interferon-gamma biosynthetic process
GO:0030101  natural killer cell activation
GO:0044130  negative regulation of growth of symbiont in host
GO:0002862  negative regulation of inflammatory response to antigenic stimulus
GO:0032693  negative regulation of interleukin-10 production
GO:0032700  negative regulation of interleukin-17 production
GO:0048662  negative regulation of smooth muscle cell proliferation
GO:0042104  positive regulation of activated T cell proliferation
GO:0010535  positive regulation of activation of JAK2 kinase activity
GO:0045785  positive regulation of cell adhesion
GO:0002230  positive regulation of defense response to virus by host
GO:0032725  positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0050729  positive regulation of inflammatory response
GO:0045078  positive regulation of interferon-gamma biosynthetic process
GO:0032729  positive regulation of interferon-gamma production
GO:0032733  positive regulation of interleukin-10 production
GO:0032735  positive regulation of interleukin-12 production
GO:0032740  positive regulation of interleukin-17 production
GO:0050671  positive regulation of lymphocyte proliferation
GO:0043382  positive regulation of memory T cell differentiation
GO:0032816  positive regulation of natural killer cell activation
GO:0002860  positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0032819  positive regulation of natural killer cell proliferation
GO:0042346  positive regulation of NF-kappaB import into nucleus
GO:0051135  positive regulation of NK T cell activation
GO:0051142  positive regulation of NK T cell proliferation
GO:0045672  positive regulation of osteoclast differentiation
GO:0034393  positive regulation of smooth muscle cell apoptosis
GO:0001916  positive regulation of T cell mediated cytotoxicity
GO:0042102  positive regulation of T cell proliferation
GO:0002827  positive regulation of T-helper 1 type immune response
GO:0034105  positive regulation of tissue remodeling
GO:0032760  positive regulation of tumor necrosis factor production
GO:0042517  positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042520  positive regulation of tyrosine phosphorylation of Stat4 protein
GO:0042523  positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042035  regulation of cytokine biosynthetic process
GO:0042510  regulation of tyrosine phosphorylation of Stat1 protein
GO:0010224  response to UV-B
GO:0019953  sexual reproduction
GO:0042088  T-helper 1 type immune response
GO:0042093  T-helper cell differentiation

Cellular Component

GO:0005737  cytoplasm
GO:0005615  extracellular space
GO:0043514  interleukin-12 complex
GO:0070743  interleukin-23 complex
GO:0016020  membrane

Molecular Function

GO:0005125  cytokine activity
GO:0004896  cytokine receptor activity
GO:0008083  growth factor activity
GO:0042802  identical protein binding
GO:0042164  interleukin-12 alpha subunit binding
GO:0005143  interleukin-12 receptor binding
GO:0045519  interleukin-23 receptor binding
GO:0005515  protein binding
GO:0046982  protein heterodimerization activity
GO:0042803  protein homodimerization activity