interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)

Synonym

IL12B, IL-12B, NKSF2, NK cell stimulatory factor chain 2, CLMF2, IL-12 p40, Interleukin-12 beta chain precursor, CLMF, NKSF, CLMF p40

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

nodata

GeneChip

cerebrum:2.62

cerebellum:2.65

brain stem:2.66

corpus callosum/glia:2.74

pineal gland:-

peripheral nerve:2.68

spine:2.59

retina:-

eye:-

artery/aorta:2.65

vein:2.65

lymphnode:2.73

peripheral blood:-

spleen:2.67

thymus:2.88

bone marrow:2.70

adipose:2.63

bone:-

skin:2.61

CAGE

cerebrum:0

cerebellum:-

brain stem:0

corpus callosum/glia:0

pineal gland:0

peripheral nerve:-

spine:0

retina:-

eye:-

artery/aorta:0

vein:0

lymphnode:0.03

peripheral blood:-

spleen:0

thymus:0.99

bone marrow:-

adipose:0

bone:-

skin:-

RNA-seq

cerebrum:0.01

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

nodata

GeneChip

uterus:2.61

placenta:2.93

prostate:2.49

ovary:2.61

testis:2.54

heart:2.69

muscle:2.63

esophagus:2.53

stomach:2.60

intestine:2.60

colon:2.64

liver/hepato:2.55

lung:2.65

bladder:-

kidney:2.54

pituitary:2.55

thyroid/parathyroid:2.63

adrenal gland:2.51

pancreas:2.63

breast:2.67

salivary:2.56

CAGE

uterus:0

placenta:0

prostate:0

ovary:0

testis:0

heart:0

muscle:0

esophagus:0

stomach:-

intestine:0

colon:0

liver/hepato:0

lung:0

bladder:0

kidney:0

pituitary:0

thyroid/parathyroid:0

adrenal gland:-

pancreas:0

breast:0

salivary:0

RNA-seq

uterus:-

placenta:-

prostate:0

ovary:0

testis:0.08

heart:0

muscle:0

esophagus:-

stomach:-

intestine:-

colon:0

liver/hepato:0

lung:0.08

bladder:-

kidney:0.02

pituitary:-

thyroid/parathyroid:0

adrenal gland:0.03

pancreas:-

breast:0.03

salivary:-

IDs

Refseq ID	NM_002187
Gene ID	3593
Unigene ID	-
Probe set ID	207901_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000113302
GTEx ID	ENSG00000113302

Orthologous Gene

Mouse[2]	NM_008352
Rat [0]

Chromosomal Region

5q33.3 [158,741,791 - 158,757,895]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

LRG_71 [5,001 - 20,691]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR003961	Fibronectin, type III
IPR008957	Fibronectin, type III-like fold

Gene Ontology (GO ID)

Biological Process

GO:0007050	cell cycle arrest
GO:0016477	cell migration
GO:0071346	cellular response to interferon-gamma
GO:0071222	cellular response to lipopolysaccharide
GO:0050829	defense response to Gram-negative bacterium
GO:0042832	defense response to protozoan
GO:0051607	defense response to virus
GO:0042095	interferon-gamma biosynthetic process
GO:0030101	natural killer cell activation
GO:0044130	negative regulation of growth of symbiont in host
GO:0002862	negative regulation of inflammatory response to antigenic stimulus
GO:0032693	negative regulation of interleukin-10 production
GO:0032700	negative regulation of interleukin-17 production
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0042104	positive regulation of activated T cell proliferation
GO:0010535	positive regulation of activation of JAK2 kinase activity
GO:0045785	positive regulation of cell adhesion
GO:0002230	positive regulation of defense response to virus by host
GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0050729	positive regulation of inflammatory response
GO:0045078	positive regulation of interferon-gamma biosynthetic process
GO:0032729	positive regulation of interferon-gamma production
GO:0032733	positive regulation of interleukin-10 production
GO:0032735	positive regulation of interleukin-12 production
GO:0032740	positive regulation of interleukin-17 production
GO:0050671	positive regulation of lymphocyte proliferation
GO:0043382	positive regulation of memory T cell differentiation
GO:0032816	positive regulation of natural killer cell activation
GO:0002860	positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0032819	positive regulation of natural killer cell proliferation
GO:0042346	positive regulation of NF-kappaB import into nucleus
GO:0051135	positive regulation of NK T cell activation
GO:0051142	positive regulation of NK T cell proliferation
GO:0045672	positive regulation of osteoclast differentiation
GO:0034393	positive regulation of smooth muscle cell apoptosis
GO:0001916	positive regulation of T cell mediated cytotoxicity
GO:0042102	positive regulation of T cell proliferation
GO:0002827	positive regulation of T-helper 1 type immune response
GO:0034105	positive regulation of tissue remodeling
GO:0032760	positive regulation of tumor necrosis factor production
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042520	positive regulation of tyrosine phosphorylation of Stat4 protein
GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042035	regulation of cytokine biosynthetic process
GO:0042510	regulation of tyrosine phosphorylation of Stat1 protein
GO:0010224	response to UV-B
GO:0019953	sexual reproduction
GO:0042088	T-helper 1 type immune response
GO:0042093	T-helper cell differentiation

Cellular Component

GO:0005737	cytoplasm
GO:0005615	extracellular space
GO:0043514	interleukin-12 complex
GO:0070743	interleukin-23 complex
GO:0016020	membrane

Molecular Function

GO:0005125	cytokine activity
GO:0004896	cytokine receptor activity
GO:0008083	growth factor activity
GO:0042802	identical protein binding
GO:0042164	interleukin-12 alpha subunit binding
GO:0005143	interleukin-12 receptor binding
GO:0045519	interleukin-23 receptor binding
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity
GO:0042803	protein homodimerization activity

interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function