integrin-linked kinase

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Synonym

p59ILK, Integrin-linked protein kinase 1, ILK1, 59 kDa serine/threonine-protein kinase, integrin-linked kinase, P59, ILK-1, ILK, DKFZp686F1765

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:7.92 cerebellum:7.88 brain stem:7.94 corpus callosum/glia:8.08 pineal gland:- peripheral nerve:8.68 spine:8.13 retina:- eye:- artery/aorta:9.86 vein:9.83 lymphnode:8.33 peripheral blood:- spleen:8.57 thymus:7.80 bone marrow:8.51 adipose:8.96 bone:- skin:8.49
CAGE cerebrum:3.23 cerebellum:- brain stem:3.19 corpus callosum/glia:3.41 pineal gland:3.42 peripheral nerve:- spine:3.25 retina:- eye:- artery/aorta:5.25 vein:3.77 lymphnode:3.44 peripheral blood:- spleen:3.64 thymus:2.67 bone marrow:- adipose:3.64 bone:- skin:-
RNA-seq cerebrum:2.74 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.67 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.02 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:9.63 placenta:8.43 prostate:9.06 ovary:8.97 testis:8.10 heart:9.01 muscle:8.26 esophagus:8.58 stomach:9.03 intestine:8.87 colon:9.10 liver/hepato:7.94 lung:8.94 bladder:- kidney:8.61 pituitary:8.29 thyroid/parathyroid:8.41 adrenal gland:8.55 pancreas:8.15 breast:9.08 salivary:8.42
CAGE uterus:4.77 placenta:3.74 prostate:4.41 ovary:3.92 testis:3.43 heart:4.28 muscle:3.54 esophagus:4.30 stomach:- intestine:3.62 colon:4.54     liver/hepato:3.22    lung:3.96 bladder:4.82 kidney:3.75 pituitary:3.08 thyroid/parathyroid:3.52 adrenal gland:- pancreas:3.71 breast:4.37 salivary:3.82
RNA-seq uterus:- placenta:- prostate:5.00 ovary:3.18 testis:3.16 heart:3.26 muscle:3.29 esophagus:- stomach:- intestine:- colon:4.22     liver/hepato:1.82        lung:4.34    bladder:- kidney:3.12 pituitary:- thyroid/parathyroid:2.42 adrenal gland:3.18 pancreas:- breast:2.91 salivary:-

IDs

Refseq ID NM_004517
Gene ID 3611
Unigene ID -
Probe set ID 201234_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000166333
GTEx ID ENSG00000166333

Orthologous Gene

Mouse[2]  NM_001161724, NM_010562
Rat[1]  NM_133409, NM_010562

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

8538749
9177792
9366252
9736715
9737788
10022929
10601309
10712922
10871859
11078733
11278835
11304546
11313365
11331308
11331582
11402068
11445557
11546794
11694518
11696434
11724787
11825911
11856758
11931630
12020426
12020826
12060675
12149249
12152651
12164932
12167643
12176337
12220642
12372433
12432066
12477932
12600888
12629168
12642872
12654898
12665801
12670870
12686550
12771992
12778079
12884912
12925691
12960424
14500673
14551191
14555513
14679308
14749128
15044083
15073119
15284246
15304053
15313908
15340074
15467740
15489334
15565145
15722199
15802621
15867245
15882985
15905178
16189514
16407822
16421303
16517730
16611685
16648553
16712791
16799642
16818815
16836071
16936772
16951248
16987993
17088456
17107957
17143519
17187779
17213807
17298394
17335036
17353931
17420447
17468516
17498677
17526737
17553790
17563721
17575101
17646580
17656471
17951996
18037995
18080083
18214046
18252715
18283114
18327965
18339839
18464290
18505933
18635968
18660489
18727519
18773488
18813944
18823942
19020711
19074270
19117955
19118217
19118218
19147542
19153670
19334037
19409087
19463178
19478459
19489119
19541809
19567202
19633364
19676046
19738201
19829382
19885839
19946888
20005845
20091050
20113654
20164304
20232298
20305688
20460506
20493167
20495362
20546345
20625942
20725137
20827300
20838383
20838384
20857141
21035499
21084641
21139048
21145461
21177334
21196412
21234586
21278793
21339732
21347395
21351095
21521694
21553049
21601006
21602880
21621326
21639857
21643011
21680733
21688303
21719054
21778429
21828040
21890473
21900206
21906983
21928230
21939655
21941415
21963094
21987572
21988832
22053931
22194624
22268729
22310280
22340785
22345562
22441983
22482400
22490953
22568984
22570869
22616551
22638656
22658851
22666394
22677169
22683084
22763012
22767580
22814720
22863883
22938462
22939624
23000965
23027626
23065574
23108908
23186335
23435415
23455922
23667531
23703635
23707970
23729269
23739974
23747271
23748822
23783575
23784942
23801886
23832543
23863169
24040439
24064223
24260102
24356468

Gene Ontology  (GO ID)

Biological Process

GO:0001658  branching involved in ureteric bud morphogenesis
GO:0007569  cell aging
GO:0007050  cell cycle arrest
GO:0034329  cell junction assembly
GO:0008283  cell proliferation
GO:0007160  cell-matrix adhesion
GO:0045197  establishment or maintenance of epithelial cell apical/basal polarity
GO:0043206  fibril organization
GO:0007229  integrin-mediated signaling pathway
GO:0032288  myelin assembly
GO:0022011  myelination in the peripheral nervous system
GO:0010667  negative regulation of cardiac muscle cell apoptosis
GO:0043524  negative regulation of neuron apoptosis
GO:0006469  negative regulation of protein kinase activity
GO:0014912  negative regulation of smooth muscle cell migration
GO:0048662  negative regulation of smooth muscle cell proliferation
GO:0021675  nerve development
GO:0048812  neuron projection morphogenesis
GO:0018105  peptidyl-serine phosphorylation
GO:0045773  positive regulation of axon extension
GO:0030513  positive regulation of BMP signaling pathway
GO:0030335  positive regulation of cell migration
GO:0008284  positive regulation of cell proliferation
GO:0001954  positive regulation of cell-matrix adhesion
GO:0050775  positive regulation of dendrite morphogenesis
GO:0043406  positive regulation of MAP kinase activity
GO:0045663  positive regulation of myoblast differentiation
GO:0045669  positive regulation of osteoblast differentiation
GO:0042327  positive regulation of phosphorylation
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0006468  protein amino acid phosphorylation
GO:0051291  protein heterooligomerization
GO:0043491  protein kinase B signaling cascade
GO:0032956  regulation of actin cytoskeleton organization
GO:0034446  substrate adhesion-dependent cell spreading

Cellular Component

GO:0043025  cell soma
GO:0005911  cell-cell junction
GO:0043034  costamere
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0043198  dendritic shaft
GO:0005925  focal adhesion
GO:0030027  lamellipodium
GO:0005886  plasma membrane
GO:0043234  protein complex
GO:0030017  sarcomere
GO:0043195  terminal button

Molecular Function

GO:0005524  ATP binding
GO:0005178  integrin binding
GO:0005515  protein binding
GO:0019901  protein kinase binding
GO:0004674  protein serine/threonine kinase activity
GO:0017124  SH3 domain binding
GO:0004871  signal transducer activity