interleukin-1 receptor-associated kinase 1

 jump to detail

Synonym

IRAK, interleukin-1 receptor-associated kinase 1, Interleukin-1 receptor-associated kinase 1, IRAK1, IRAK-1, pelle

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:11.90 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:- retina:- eye:105.80 artery/aorta:60 vein:66.60 lymphnode:60.70 peripheral blood:54.70 spleen:- thymus:12.90 bone marrow:59 adipose:121 bone:64 skin:28.80
GeneChip cerebrum:6.62 cerebellum:6.21 brain stem:6.80 corpus callosum/glia:6.64 pineal gland:- peripheral nerve:6.99 spine:7.31 retina:- eye:- artery/aorta:7.22 vein:7.12 lymphnode:8.01 peripheral blood:- spleen:7.92 thymus:7.20 bone marrow:7.56 adipose:7.41 bone:- skin:7.73
CAGE cerebrum:2.85 cerebellum:- brain stem:2.93 corpus callosum/glia:3.06 pineal gland:2.66 peripheral nerve:- spine:3.23 retina:- eye:- artery/aorta:3.10 vein:3.42 lymphnode:4.05 peripheral blood:- spleen:4.09 thymus:3.27 bone marrow:- adipose:3.71 bone:- skin:-
RNA-seq cerebrum:1.67 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.93 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.18 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:27.30 placenta:58.30 prostate:135.20 ovary:37.30 testis:17.30 heart:51.10 muscle:20.10 esophagus:- stomach:63.70 intestine:- colon:84.80     liver/hepato:21.10        lung:29.30    bladder:- kidney:52 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:17.80 breast:- salivary:-
GeneChip uterus:6.78 placenta:6.69 prostate:7.74 ovary:7.09 testis:6.93 heart:6.63 muscle:6.50 esophagus:8.07 stomach:7.52 intestine:7.84 colon:7.53 liver/hepato:7.15 lung:7.35 bladder:- kidney:7.30 pituitary:6.88 thyroid/parathyroid:6.92 adrenal gland:7.84 pancreas:7.84 breast:7.62 salivary:7.99
CAGE uterus:3.04 placenta:3.18 prostate:3.42 ovary:3.35 testis:3.28 heart:3.33 muscle:3.33 esophagus:3.83 stomach:- intestine:4.14 colon:3.95     liver/hepato:4.27    lung:3.69 bladder:3.46 kidney:3.73 pituitary:2.46 thyroid/parathyroid:3.05 adrenal gland:- pancreas:4.03 breast:4.33 salivary:3.64
RNA-seq uterus:- placenta:- prostate:2.85 ovary:3.34 testis:2.89 heart:2.04 muscle:3.12 esophagus:- stomach:- intestine:- colon:2.94     liver/hepato:3.03        lung:2.42    bladder:- kidney:3.65 pituitary:- thyroid/parathyroid:3.88 adrenal gland:4.25 pancreas:- breast:3.82 salivary:-

Gene Information

IDs

Refseq ID NM_001569
Gene ID 3654
Unigene ID Hs.522819
Probe set ID 201587_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000184216
GTEx ID ENSG00000184216

Orthologous Gene

Mouse[4]  NM_001177973, NM_001177974, NM_001177975, NM_001177976, NM_008363
Rat[1]  NM_001127555, NM_001177974, NM_001177975, NM_001177976, NM_008363

Chromosomal Region

Xq28  [153,275,951  -  153,285,431]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

8599092
8837778
9252186
9371760
9374458
9426216
9575168
9625770
9915784
9918122
10022904
10191251
10346818
10383454
10395652
10395695
10465784
10723722
10747026
10854325
10899313
10920205
11076863
11096118
11244088
11259596
11287640
11397809
11518704
11544529
11701612
11744690
11777917
11828002
11937546
11953430
11960013
11976320
12034707
12054681
12055225
12138165
12242293
12370331
12391239
12477932
12496252
12538665
12566447
12609980
12619925
12721283
12724322
12856330
12860405
12874243
12925853
14625308
14684752
14752294
15069085
15084582
15276183
15388348
15465816
15489334
15489336
15523691
15647277
15691841
15767370
15829295
15894263
15917247
16024789
16052631
16094384
16107720
16203735
16286016
16381901
16461741
16477006
16528020
16537705
16690127
16831874
16884718
16907704
16951688
16997282
17053167
17113392
17197697
17276401
17314511
17382928
17548806
17675297
17785851
17878161
17905570
17920759
17997719
18050247
18056395
18070982
18079163
18180283
18221795
18234474
18276832
18326498
18347055
18411265
18474871
18524972
18566305
18724939
18987746
19025640
19026643
19081057
19104650
19166926
19166933
19181383
19185524
19264966
19264973
19282863
19288030
19329491
19453261
19505919
19675569
19716405
19838195
19913121
19948975
20043910
20044140
20056178
20092701
20400509
20448286
20463618
20500689
20542134
20562859
20619458
20628086
20676093
20870441
20890200
20937840
21145461
21160042
21204785
21220427
21435586
21537341
21640790
21708940
21804018
21890473
21898345
21903422
21906983
21911421
21933552
21963094
21987572
22011580
22033216
22033459
22059479
22447928
22451023
22505724
22678362
22759955
22797925
22851693
22896623
22904187
22904263
23000965
23018031
23041547
23233309
23244239
23381138
23383610
23396947
23428850
23435933
23444193
23633945
23776175
23867959
23986494
24434549
24469975
24491438
24735611

Gene Ontology  (GO ID)

Biological Process

GO:0000187  activation of MAPK activity
GO:0007250  activation of NF-kappaB-inducing kinase activity
GO:0071456  cellular response to hypoxia
GO:0045087  innate immune response
GO:0070498  interleukin-1-mediated signaling pathway
GO:0007254  JNK cascade
GO:0031663  lipopolysaccharide-mediated signaling pathway
GO:0002755  MyD88-dependent toll-like receptor signaling pathway
GO:0002756  MyD88-independent toll-like receptor signaling pathway
GO:0043066  negative regulation of apoptosis
GO:0032088  negative regulation of NF-kappaB transcription factor activity
GO:0048011  nerve growth factor receptor signaling pathway
GO:0070423  nucleotide-binding oligomerization domain containing signaling pathway
GO:0043123  positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0048661  positive regulation of smooth muscle cell proliferation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0051259  protein oligomerization
GO:0016567  protein ubiquitination
GO:0001959  regulation of cytokine-mediated signaling pathway
GO:0070555  response to interleukin-1
GO:0032496  response to lipopolysaccharide
GO:0032494  response to peptidoglycan
GO:0007165  signal transduction
GO:0051403  stress-activated MAPK cascade
GO:0034166  toll-like receptor 10 signaling pathway
GO:0034134  toll-like receptor 2 signaling pathway
GO:0034138  toll-like receptor 3 signaling pathway
GO:0034142  toll-like receptor 4 signaling pathway
GO:0034146  toll-like receptor 5 signaling pathway
GO:0034162  toll-like receptor 9 signaling pathway
GO:0002224  toll-like receptor signaling pathway
GO:0007178  transmembrane receptor protein serine/threonine kinase signaling pathway

Cellular Component

GO:0005829  cytosol
GO:0010008  endosome membrane
GO:0045323  interleukin-1 receptor complex
GO:0005811  lipid particle
GO:0005634  nucleus
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0005149  interleukin-1 receptor binding
GO:0016301  kinase activity
GO:0004704  NF-kappaB-inducing kinase activity
GO:0005515  protein binding
GO:0046982  protein heterodimerization activity
GO:0042803  protein homodimerization activity
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0004842  ubiquitin-protein ligase activity