interferon regulatory factor 4

Synonym

Multiple myeloma oncogene 1, Interferon regulatory factor 4, IRF-4, MUM1, IRF4, interferon regulatory factor 4, LSIRF, NF-EM5, Lymphocyte-specific interferon regulatory factor

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:2.40

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:112.30

retina:-

eye:5.90

artery/aorta:-

vein:-

lymphnode:273

peripheral blood:72.90

spleen:37.80

thymus:12.90

bone marrow:19.70

adipose:-

bone:38.40

skin:76.80

GeneChip

cerebrum:6.07

cerebellum:5.87

brain stem:6.06

corpus callosum/glia:5.99

pineal gland:-

peripheral nerve:6.17

spine:6.17

retina:-

eye:-

artery/aorta:6.37

vein:6.05

lymphnode:7.14

peripheral blood:-

spleen:7.03

thymus:6.43

bone marrow:6.84

adipose:6.41

bone:-

skin:6.46

CAGE

cerebrum:0.11

cerebellum:-

brain stem:0.30

corpus callosum/glia:0.47

pineal gland:0.21

peripheral nerve:-

spine:0.40

retina:-

eye:-

artery/aorta:1.88

vein:3.80

lymphnode:4.34

peripheral blood:-

spleen:4.19

thymus:3.26

bone marrow:-

adipose:2.78

bone:-

skin:-

RNA-seq

cerebrum:0.00

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:2.81

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:1.63

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:9.10

placenta:-

prostate:11.30

ovary:-

testis:125.50

heart:12.80

muscle:-

esophagus:-

stomach:212.40

intestine:64.80

colon:-

liver/hepato:-

lung:9.80

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:9.30

salivary:-

GeneChip

uterus:5.98

placenta:5.98

prostate:5.82

ovary:5.78

testis:5.92

heart:5.87

muscle:6

esophagus:5.85

stomach:6.59

intestine:6.39

colon:6.55

liver/hepato:5.99

lung:6.16

bladder:-

kidney:5.89

pituitary:6.05

thyroid/parathyroid:5.96

adrenal gland:5.75

pancreas:6.12

breast:6.17

salivary:6

CAGE

uterus:2.21

placenta:0.77

prostate:1.51

ovary:1.59

testis:1.52

heart:0.93

muscle:0.72

esophagus:2.63

stomach:-

intestine:2.90

colon:3.04

liver/hepato:2.35

lung:2.47

bladder:2.87

kidney:1.40

pituitary:0

thyroid/parathyroid:0.98

adrenal gland:-

pancreas:0.94

breast:2.02

salivary:3.05

RNA-seq

uterus:-

placenta:-

prostate:0.00

ovary:0.30

testis:0.01

heart:0.00

muscle:0.00

esophagus:-

stomach:-

intestine:-

colon:0.01

liver/hepato:0.00

lung:0.96

bladder:-

kidney:0.00

pituitary:-

thyroid/parathyroid:0.00

adrenal gland:2.47

pancreas:-

breast:0.26

salivary:-

IDs

Refseq ID	NM_002460
Gene ID	3662
Unigene ID	Hs.401013
Probe set ID	204562_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000137265
GTEx ID	ENSG00000137265

Orthologous Gene

Mouse[2]	NM_013674
Rat[1]	NM_001106108

Chromosomal Region

6p25.3 [391,739 - 411,447]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR001346	Interferon regulatory factor
IPR011991	Winged helix repressor DNA-binding

Gene Ontology (GO ID)

Biological Process

GO:0019221	cytokine-mediated signaling pathway
GO:0042832	defense response to protozoan
GO:0043966	histone H3 acetylation
GO:0043967	histone H4 acetylation
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0043011	myeloid dendritic cell differentiation
GO:0034122	negative regulation of toll-like receptor signaling pathway
GO:0043388	positive regulation of DNA binding
GO:0045082	positive regulation of interleukin-10 biosynthetic process
GO:0045368	positive regulation of interleukin-13 biosynthetic process
GO:0045086	positive regulation of interleukin-2 biosynthetic process
GO:0045404	positive regulation of interleukin-4 biosynthetic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045893	positive regulation of transcription, DNA-dependent
GO:0045622	regulation of T-helper cell differentiation
GO:0042110	T cell activation
GO:0006351	transcription, DNA-dependent
GO:0060337	type I interferon-mediated signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0000788	nuclear nucleosome
GO:0005730	nucleolus
GO:0005634	nucleus

Molecular Function

GO:0005515	protein binding
GO:0016279	protein-lysine N-methyltransferase activity
GO:0043565	sequence-specific DNA binding
GO:0003700	transcription factor activity
GO:0008134	transcription factor binding

interferon regulatory factor 4

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function