interferon regulatory factor 7

 jump to detail

Synonym

interferon regulatory factor 7, IRF-7H, IRF7A, IRF7, IRF-7, Interferon regulatory factor 7

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:24.90 cerebellum:12.60 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:61.30 spine:112.30 retina:- eye:23.50 artery/aorta:- vein:- lymphnode:111.20 peripheral blood:291.50 spleen:37.80 thymus:38.70 bone marrow:39.40 adipose:- bone:25.60 skin:4.80
GeneChip cerebrum:5.11 cerebellum:5.56 brain stem:5.08 corpus callosum/glia:5.64 pineal gland:- peripheral nerve:6.10 spine:5.63 retina:- eye:- artery/aorta:6.44 vein:5.90 lymphnode:7.79 peripheral blood:- spleen:8.09 thymus:6.85 bone marrow:6.75 adipose:6.42 bone:- skin:6.40
CAGE cerebrum:2.28 cerebellum:- brain stem:2.44 corpus callosum/glia:2.27 pineal gland:1.96 peripheral nerve:- spine:2.85 retina:- eye:- artery/aorta:2.66 vein:3.52 lymphnode:3.47 peripheral blood:- spleen:3.60 thymus:2.99 bone marrow:- adipose:3.28 bone:- skin:-
RNA-seq cerebrum:0.35 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.93 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.42 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:27.30 placenta:29.10 prostate:11.30 ovary:74.50 testis:8.70 heart:25.50 muscle:- esophagus:- stomach:21.20 intestine:- colon:33.90     liver/hepato:10.60        lung:48.90    bladder:125.60 kidney:31.20 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:80 breast:27.90 salivary:-
GeneChip uterus:5.95 placenta:6.02 prostate:6.32 ovary:5.86 testis:5.26 heart:6.11 muscle:5.60 esophagus:6.52 stomach:6.40 intestine:6.24 colon:5.93 liver/hepato:7.25 lung:7.62 bladder:- kidney:5.90 pituitary:5.68 thyroid/parathyroid:6.48 adrenal gland:5.70 pancreas:5.88 breast:6.35 salivary:6.31
CAGE uterus:2.17 placenta:2.60 prostate:2.82 ovary:2.70 testis:1.90 heart:2.76 muscle:2.59 esophagus:2.60 stomach:- intestine:2.78 colon:2.71     liver/hepato:3.69    lung:3.49 bladder:1.93 kidney:2.67 pituitary:2.36 thyroid/parathyroid:3.15 adrenal gland:- pancreas:2.41 breast:3.52 salivary:2.22
RNA-seq uterus:- placenta:- prostate:0.40 ovary:0.80 testis:0.26 heart:0.46 muscle:0.18 esophagus:- stomach:- intestine:- colon:0.20     liver/hepato:0.80        lung:1.42    bladder:- kidney:0.39 pituitary:- thyroid/parathyroid:1.19 adrenal gland:1.33 pancreas:- breast:1.14 salivary:-

Gene Information

IDs

Refseq ID NM_004031
Gene ID 3665
Unigene ID Hs.166120
Probe set ID 208436_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000185507
GTEx ID ENSG00000185507

Orthologous Gene

Mouse[1]  NM_016850
Rat [0]  

Chromosomal Region

11p15.5  [612,553  -  615,999]

Gene Family (Interpro ID)

IPR001346  Interferon regulatory factor
IPR011991  Winged helix repressor DNA-binding

Link to Pubmed  (Pubmed ID)

9315633
9660935
9786932
9865487
10924517
11031102
11073981
11124948
11162841
11314014
11846980
11877397
11884139
11943871
12374802
12477932
12539042
12604599
12692549
12915551
14517278
14729983
14739303
14747533
14759258
14968112
15251447
15265881
15276183
15308637
15361868
15664159
15664995
15695821
15767370
16127453
16153868
16237059
16341674
16344560
16484229
16778376
16979567
17079482
17121613
17374731
17393359
17404045
17522209
17599067
17823124
18227218
18397234
18505922
18539711
18635538
18641315
18710948
18922877
18987133
19017798
19152337
19285439
19349300
19404407
19426920
19515829
19858727
19880818
20112359
20154210
20209099
20331378
20381110
20392859
20467438
20483755
20581830
20588308
20628624
20668674
20689596
20810735
20844090
20943654
20962850
20980251
20980500
21084487
21167895
21183682
21360504
21435390
21632682
21890473
21903422
21906983
21926187
21931555
21940674
21988832
22095711
22112518
22140520
22194884
22301143
22433914
22455868
22505724
22588174
22709905
22787218
22820642
23175366
23490285
23535064
23740937
23846693
23956435
24275658
24385435

Gene Ontology  (GO ID)

Biological Process

GO:0019221  cytokine-mediated signaling pathway
GO:0019043  establishment of viral latency
GO:0016064  immunoglobulin mediated immune response
GO:0045087  innate immune response
GO:0032607  interferon-alpha production
GO:0032608  interferon-beta production
GO:0060333  interferon-gamma-mediated signaling pathway
GO:0002756  MyD88-independent toll-like receptor signaling pathway
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0032727  positive regulation of interferon-alpha production
GO:0032728  positive regulation of interferon-beta production
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0032481  positive regulation of type I interferon production
GO:0060340  positive regulation of type I interferon-mediated signaling pathway
GO:0002819  regulation of adaptive immune response
GO:0050776  regulation of immune response
GO:0045655  regulation of monocyte differentiation
GO:0034124  regulation of MyD88-dependent toll-like receptor signaling pathway
GO:0034127  regulation of MyD88-independent toll-like receptor signaling pathway
GO:0032479  regulation of type I interferon production
GO:0006974  response to DNA damage stimulus
GO:0009615  response to virus
GO:0034138  toll-like receptor 3 signaling pathway
GO:0034142  toll-like receptor 4 signaling pathway
GO:0034162  toll-like receptor 9 signaling pathway
GO:0002224  toll-like receptor signaling pathway
GO:0006366  transcription from RNA polymerase II promoter
GO:0045351  type I interferon biosynthetic process
GO:0060337  type I interferon-mediated signaling pathway
GO:0019048  virus-host interaction

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0010008  endosome membrane
GO:0005654  nucleoplasm
GO:0005634  nucleus

Molecular Function

GO:0003677  DNA binding
GO:0005515  protein binding