ISL LIM homeobox 1

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Synonym

Insulin gene enhancer protein ISL-1, ISL1, Islet-1, Isl-1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:64 cerebellum:37.80 brain stem:- corpus callosum/glia:- pineal gland:445 peripheral nerve:61.30 spine:112.30 retina:- eye:152.80 artery/aorta:- vein:- lymphnode:70.80 peripheral blood:18.20 spleen:37.80 thymus:51.50 bone marrow:59 adipose:- bone:12.80 skin:9.60
GeneChip cerebrum:3.68 cerebellum:3.70 brain stem:3.39 corpus callosum/glia:3.77 pineal gland:- peripheral nerve:6.26 spine:3.72 retina:- eye:- artery/aorta:3.61 vein:3.40 lymphnode:3.56 peripheral blood:- spleen:3.46 thymus:5.18 bone marrow:3.58 adipose:4.45 bone:- skin:3.61
CAGE cerebrum:0.30 cerebellum:- brain stem:0.03 corpus callosum/glia:0.07 pineal gland:0.21 peripheral nerve:- spine:0.09 retina:- eye:- artery/aorta:0.87 vein:0.96 lymphnode:0.15 peripheral blood:- spleen:0 thymus:1.16 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:0.02 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.18 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.02 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:45.60 placenta:61.90 prostate:78.90 ovary:111.80 testis:95.20 heart:76.60 muscle:- esophagus:342.80 stomach:- intestine:- colon:17     liver/hepato:10.60        lung:29.30    bladder:- kidney:62.40 pituitary:- thyroid/parathyroid:163.70 adrenal gland:- pancreas:97.80 breast:37.20 salivary:-
GeneChip uterus:4.80 placenta:5.14 prostate:6.85 ovary:3.37 testis:4.74 heart:3.39 muscle:3.39 esophagus:3.84 stomach:7.04 intestine:4.32 colon:3.56 liver/hepato:3.31 lung:3.45 bladder:- kidney:3.29 pituitary:5.16 thyroid/parathyroid:3.54 adrenal gland:3.51 pancreas:4.58 breast:3.77 salivary:3.60
CAGE uterus:1.73 placenta:2.12 prostate:2.52 ovary:0 testis:0.80 heart:0.19 muscle:0.05 esophagus:0.18 stomach:- intestine:0.38 colon:0.46     liver/hepato:0.14    lung:0.05 bladder:1.15 kidney:0.08 pituitary:0.56 thyroid/parathyroid:0.17 adrenal gland:- pancreas:1.98 breast:0 salivary:0
RNA-seq uterus:- placenta:- prostate:1.04 ovary:0.00 testis:1.46 heart:0 muscle:0 esophagus:- stomach:- intestine:- colon:0.30     liver/hepato:0        lung:0    bladder:- kidney:0 pituitary:- thyroid/parathyroid:0.22 adrenal gland:0 pancreas:- breast:0 salivary:-

Gene Information

IDs

Refseq ID NM_002202
Gene ID 3670
Unigene ID Hs.505004
Probe set ID 206104_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000016082
GTEx ID ENSG00000016082

Orthologous Gene

Mouse[2]  NM_021459
Rat [0]  

Chromosomal Region

5q11.1  [50,678,958  -  50,690,564]

Gene Family (Interpro ID)

IPR001356  Homeobox
IPR009057  Homeodomain-like
IPR012287  Homeodomain-related

Link to Pubmed  (Pubmed ID)

1685766
7789634
7907017
7912209
8565076
8889548
9000074
9452425
9849969
10431247
11043578
11882901
12477932
15161765
15489334
15839736
15843409
16321656
16713999
16873704
17022998
17363077
17519333
18081024
18239644
18454440
18583962
19571884
19619559
19896915
20211142
20306291
20520780
20807224
21060249
21145461
21739268
21832049
21988832
22094256
22194342
22303449
22388755
22480195
23152444
23229290
23259602
23348208
23436614
23455924
23503646
23572340
24018375
24037217
24131831

Gene Ontology  (GO ID)

Biological Process

GO:0060413  atrial septum morphogenesis
GO:0031103  axon regeneration
GO:0060913  cardiac cell fate determination
GO:0060379  cardiac muscle cell myoblast differentiation
GO:0003215  cardiac right ventricle morphogenesis
GO:0071385  cellular response to glucocorticoid stimulus
GO:0003203  endocardial cushion morphogenesis
GO:0060384  innervation
GO:0048762  mesenchymal cell differentiation
GO:0033147  negative regulation of estrogen receptor signaling pathway
GO:0050728  negative regulation of inflammatory response
GO:0043524  negative regulation of neuron apoptosis
GO:0045665  negative regulation of neuron differentiation
GO:0090074  negative regulation of protein homodimerization activity
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0090090  negative regulation of Wnt receptor signaling pathway through beta-catenin
GO:0001755  neural crest cell migration
GO:0048665  neuron fate specification
GO:0003151  outflow tract morphogenesis
GO:0003148  outflow tract septum morphogenesis
GO:0031016  pancreas development
GO:0048936  peripheral nervous system neuron axonogenesis
GO:0060037  pharyngeal system development
GO:0021983  pituitary gland development
GO:0045766  positive regulation of angiogenesis
GO:0008284  positive regulation of cell proliferation
GO:0043388  positive regulation of DNA binding
GO:0032725  positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032024  positive regulation of insulin secretion
GO:0032729  positive regulation of interferon-gamma production
GO:0032730  positive regulation of interleukin-1 alpha production
GO:0032731  positive regulation of interleukin-1 beta production
GO:0032735  positive regulation of interleukin-12 production
GO:0032755  positive regulation of interleukin-6 production
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0032760  positive regulation of tumor necrosis factor production
GO:0042517  positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0010575  positive regulation vascular endothelial growth factor production
GO:0003266  regulation of second heart field cardioblast proliferation
GO:0031290  retinal ganglion cell axon guidance
GO:0003139  secondary heart field specification
GO:0048880  sensory system development
GO:0021520  spinal cord motor neuron cell fate specification
GO:0021522  spinal cord motor neuron differentiation
GO:0021559  trigeminal nerve development
GO:0055010  ventricular cardiac muscle tissue morphogenesis
GO:0021524  visceral motor neuron differentiation

Cellular Component

GO:0005737  cytoplasm
GO:0005634  nucleus

Molecular Function

GO:0043425  bHLH transcription factor binding
GO:0003682  chromatin binding
GO:0030331  estrogen receptor binding
GO:0016922  ligand-dependent nuclear receptor binding
GO:0003700  transcription factor activity
GO:0008270  zinc ion binding