integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)

Synonym

Vitronectin receptor subunit alpha, antigen identified by monoclonal antibody L230, ITGAV, VNRA, CD51, MSK8, CD51 antigen, Integrin alpha-V precursor

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:58.10

cerebellum:25.20

brain stem:-

corpus callosum/glia:116.60

pineal gland:-

peripheral nerve:61.30

spine:112.30

retina:355.90

eye:111.70

artery/aorta:119.90

vein:-

lymphnode:20.20

peripheral blood:18.20

spleen:-

thymus:64.40

bone marrow:19.70

adipose:40.30

bone:153.50

skin:96

GeneChip

cerebrum:8.34

cerebellum:8

brain stem:8.65

corpus callosum/glia:8.84

pineal gland:-

peripheral nerve:9.20

spine:9.37

retina:-

eye:-

artery/aorta:8.97

vein:8.55

lymphnode:7.81

peripheral blood:-

spleen:7.57

thymus:7.99

bone marrow:5.18

adipose:8.22

bone:-

skin:8.53

CAGE

cerebrum:4.26

cerebellum:-

brain stem:4.55

corpus callosum/glia:4.56

pineal gland:4.16

peripheral nerve:-

spine:4.78

retina:-

eye:-

artery/aorta:4.85

vein:3.78

lymphnode:3.41

peripheral blood:-

spleen:3.91

thymus:3.35

bone marrow:-

adipose:4.57

bone:-

skin:-

RNA-seq

cerebrum:1.34

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0.00

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:2.47

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:127.60

placenta:105.60

prostate:56.30

ovary:37.30

testis:38.90

heart:89.40

muscle:60.30

esophagus:-

stomach:21.20

intestine:97.20

colon:33.90

liver/hepato:63.30

lung:112.40

bladder:-

kidney:104

pituitary:-

thyroid/parathyroid:-

adrenal gland:50.80

pancreas:133.40

breast:148.70

salivary:-

GeneChip

uterus:9.32

placenta:9.15

prostate:9.05

ovary:9.20

testis:7.34

heart:8.83

muscle:7.54

esophagus:7.26

stomach:8.12

intestine:8.06

colon:6.25

liver/hepato:6.57

lung:8.13

bladder:-

kidney:8.27

pituitary:7.60

thyroid/parathyroid:8.91

adrenal gland:8.60

pancreas:6.95

breast:8.22

salivary:8.26

CAGE

uterus:4.63

placenta:4.69

prostate:4.18

ovary:4.42

testis:3.89

heart:4.64

muscle:3.45

esophagus:4.05

stomach:-

intestine:3.69

colon:3.83

liver/hepato:3.49

lung:4.17

bladder:4.19

kidney:5.27

pituitary:3.92

thyroid/parathyroid:4.49

adrenal gland:-

pancreas:4.20

breast:4.66

salivary:4.39

RNA-seq

uterus:-

placenta:-

prostate:0.00

ovary:1.09

testis:0.97

heart:2.03

muscle:1.91

esophagus:-

stomach:-

intestine:-

colon:0.98

liver/hepato:0.00

lung:0.31

bladder:-

kidney:1.42

pituitary:-

thyroid/parathyroid:2.04

adrenal gland:0.00

pancreas:-

breast:1.76

salivary:-

IDs

Refseq ID	NM_002210
Gene ID	3685
Unigene ID	Hs.436873
Probe set ID	202351_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000138448
GTEx ID	ENSG00000138448

Orthologous Gene

Mouse[3]	NM_008402
Rat[3]	NM_008402

Chromosomal Region

2q32.1 [187,454,790 - 187,545,628]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR013517	FG-GAP
IPR013519	Integrin alpha beta-propellor

Gene Ontology (GO ID)

Biological Process

GO:0001525	angiogenesis
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0043277	apoptotic cell clearance
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0070588	calcium ion transmembrane transport
GO:0007155	cell adhesion
GO:0007160	cell-matrix adhesion
GO:0052066	entry of symbiont into host cell by promotion of host phagocytosis
GO:0046718	entry of virus into host cell
GO:0070371	ERK1 and ERK2 cascade
GO:0030198	extracellular matrix organization
GO:0007229	integrin-mediated signaling pathway
GO:0050900	leukocyte migration
GO:0043066	negative regulation of apoptosis
GO:0010888	negative regulation of lipid storage
GO:0032369	negative regulation of lipid transport
GO:0050748	negative regulation of lipoprotein metabolic process
GO:0045715	negative regulation of low-density lipoprotein receptor biosynthetic process
GO:0010745	negative regulation of macrophage derived foam cell differentiation
GO:0045785	positive regulation of cell adhesion
GO:0030335	positive regulation of cell migration
GO:0008284	positive regulation of cell proliferation
GO:0033690	positive regulation of osteoblast proliferation
GO:0050764	regulation of phagocytosis
GO:0019048	virus-host interaction

Cellular Component

GO:0009986	cell surface
GO:0009897	external side of plasma membrane
GO:0005887	integral to plasma membrane
GO:0008305	integrin complex
GO:0016020	membrane
GO:0045335	phagocytic vesicle
GO:0005886	plasma membrane

Molecular Function

GO:0031994	insulin-like growth factor I binding
GO:0046872	metal ion binding
GO:0001846	opsonin binding
GO:0005515	protein binding
GO:0005080	protein kinase C binding
GO:0050431	transforming growth factor beta binding
GO:0005245	voltage-gated calcium channel activity

integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function