inositol 1,4,5-triphosphate receptor, type 1

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Synonym

IP3R1, inositol 1,4,5-triphosphate receptor, type 1, Type 1 inositol 1,4,5-trisphosphate receptor, IP3 receptor isoform 1, Insp3r1, Inositol 1,4,5-trisphosphate receptor type 1, ITPR1, InsP3R1, IP3R, INSP3R1, Type 1 InsP3 receptor

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:115 cerebellum:163.70 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:122.70 spine:- retina:118.60 eye:58.80 artery/aorta:- vein:- lymphnode:151.70 peripheral blood:18.20 spleen:18.90 thymus:90.20 bone marrow:19.70 adipose:- bone:38.40 skin:67.20
GeneChip cerebrum:7.08 cerebellum:8.89 brain stem:6.28 corpus callosum/glia:4.51 pineal gland:- peripheral nerve:5.56 spine:4.94 retina:- eye:- artery/aorta:7.41 vein:6.99 lymphnode:6.53 peripheral blood:- spleen:6.76 thymus:6.77 bone marrow:4.53 adipose:5.82 bone:- skin:5.44
CAGE cerebrum:4.16 cerebellum:- brain stem:2.91 corpus callosum/glia:2.92 pineal gland:4.54 peripheral nerve:- spine:2.39 retina:- eye:- artery/aorta:4.15 vein:3.65 lymphnode:3.71 peripheral blood:- spleen:3.75 thymus:3.71 bone marrow:- adipose:3.44 bone:- skin:-
RNA-seq cerebrum:3.11 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.00 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.04 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:218.70 placenta:40.10 prostate:112.60 ovary:- testis:51.90 heart:25.50 muscle:- esophagus:- stomach:21.20 intestine:32.40 colon:50.90     liver/hepato:126.70        lung:107.50    bladder:- kidney:187.10 pituitary:232 thyroid/parathyroid:- adrenal gland:253.90 pancreas:26.70 breast:55.80 salivary:-
GeneChip uterus:7.25 placenta:5.26 prostate:7.49 ovary:7.54 testis:5 heart:6.33 muscle:3.96 esophagus:5.31 stomach:6.47 intestine:5.72 colon:5.47 liver/hepato:4.29 lung:6.75 bladder:- kidney:6.84 pituitary:7.26 thyroid/parathyroid:8.11 adrenal gland:6.92 pancreas:4.29 breast:6.89 salivary:6.90
CAGE uterus:4.50 placenta:2.76 prostate:4.58 ovary:4.29 testis:3.28 heart:3.27 muscle:2.19 esophagus:3.59 stomach:- intestine:2.84 colon:3.25     liver/hepato:2.80    lung:3.51 bladder:4.40 kidney:3.41 pituitary:3.58 thyroid/parathyroid:4.04 adrenal gland:- pancreas:1.59 breast:2.59 salivary:4.31
RNA-seq uterus:- placenta:- prostate:0.60 ovary:1.35 testis:0.60 heart:0.18 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.13     liver/hepato:0        lung:0.26    bladder:- kidney:1.03 pituitary:- thyroid/parathyroid:1.30 adrenal gland:0.63 pancreas:- breast:0.83 salivary:-

Gene Information

IDs

Refseq ID NM_001168272
Gene ID 3708
Unigene ID Hs.567295
Probe set ID 203710_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000150995
GTEx ID ENSG00000150995

Orthologous Gene

Mouse[2]  NM_010585
Rat [0]  

Chromosomal Region

3p26.1  [4,535,032  -  4,889,524]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

1693919
7500840
7559486
7852357
7945203
8132516
8132598
8521476
8648241
8713116
8889548
9278393
9346894
9511764
9607712
9808459
9853757
10209024
10724174
10737800
10828023
10843712
10874040
11163362
11329013
11413485
11445634
11524429
11574661
11587548
11723290
11782428
11956293
12032348
12196544
12356940
12444087
12477932
12480535
12525476
12529267
12606542
12611586
12676536
12717445
12754204
12766172
12828938
14505576
14570872
14635192
14685260
14697242
14707143
14761954
14981189
15067324
15104175
15146197
15148151
15613488
15623527
15623688
15652484
16091359
16223735
16237118
16278292
16344560
16454711
16621795
16723353
16844763
16990268
16990611
17081983
17130290
17256008
17437169
17502376
17590087
17690304
17696464
17932120
18056410
18303017
18364356
18579805
18657507
18708078
18990696
19120137
19147678
19240031
19325567
19429868
19666470
19730683
19854836
19934645
19946888
20082166
20301317
20301536
20360068
20379614
20395455
20427533
20437544
20632399
20669319
21046461
21071436
21139048
21367767
21382133
21457704
21555639
21762810
21784978
21827915
21963094
22318346
22473799
22761998
22818390
22837378
22855054
22872699
22929228
22986007
23122728
23251661
23535729
23553787
23582047
23955339
23983250
24078636
24602615

Gene Ontology  (GO ID)

Biological Process

GO:0007202  activation of phospholipase C activity
GO:0070059  apoptosis in response to endoplasmic reticulum stress
GO:0007596  blood coagulation
GO:0006816  calcium ion transport
GO:0006112  energy reserve metabolic process
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0008543  fibroblast growth factor receptor signaling pathway
GO:0045087  innate immune response
GO:0048016  inositol phosphate-mediated signaling
GO:0048011  nerve growth factor receptor signaling pathway
GO:0030168  platelet activation
GO:0050796  regulation of insulin secretion
GO:0051209  release of sequestered calcium ion into cytosol
GO:0001666  response to hypoxia
GO:0007165  signal transduction

Cellular Component

GO:0005783  endoplasmic reticulum
GO:0005789  endoplasmic reticulum membrane
GO:0016021  integral to membrane
GO:0031088  platelet dense granule membrane
GO:0031094  platelet dense tubular network
GO:0031095  platelet dense tubular network membrane

Molecular Function

GO:0015085  calcium ion transmembrane transporter activity
GO:0005220  inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0005218  intracellular ligand-gated calcium channel activity
GO:0035091  phosphoinositide binding
GO:0005515  protein binding