inositol 1,4,5-triphosphate receptor, type 2

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Synonym

Inositol 1,4,5-trisphosphate receptor type 2, Type 2 inositol 1,4,5-trisphosphate receptor, InsP3R2, ITPR2, IP3R2, Type 2 InsP3 receptor, IP3 receptor isoform 2, inositol 1,4,5-triphosphate receptor, type 2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:56.90 cerebellum:- brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:30.70 spine:- retina:355.90 eye:64.60 artery/aorta:89.90 vein:- lymphnode:182 peripheral blood:36.40 spleen:37.80 thymus:309.20 bone marrow:118.10 adipose:- bone:51.20 skin:72
GeneChip cerebrum:5.98 cerebellum:5.88 brain stem:6.01 corpus callosum/glia:6.11 pineal gland:- peripheral nerve:6.25 spine:6.09 retina:- eye:- artery/aorta:6.06 vein:5.99 lymphnode:6.29 peripheral blood:- spleen:6.59 thymus:7.27 bone marrow:6.19 adipose:6.15 bone:- skin:5.90
CAGE cerebrum:3.28 cerebellum:- brain stem:3.83 corpus callosum/glia:3.48 pineal gland:3.93 peripheral nerve:- spine:4.26 retina:- eye:- artery/aorta:3.14 vein:3.74 lymphnode:3.44 peripheral blood:- spleen:3.88 thymus:4.67 bone marrow:- adipose:3.38 bone:- skin:-
RNA-seq cerebrum:2.33 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.28 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.27 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:72.90 placenta:69.20 prostate:33.80 ovary:- testis:30.30 heart:12.80 muscle:60.30 esophagus:- stomach:85 intestine:32.40 colon:84.80     liver/hepato:84.40        lung:58.70    bladder:- kidney:176.80 pituitary:- thyroid/parathyroid:- adrenal gland:253.90 pancreas:71.10 breast:223 salivary:328.40
GeneChip uterus:6 placenta:6.01 prostate:5.86 ovary:6.29 testis:5.55 heart:5.86 muscle:6.05 esophagus:6.51 stomach:6.29 intestine:6.10 colon:6.27 liver/hepato:7.68 lung:6.42 bladder:- kidney:6.39 pituitary:5.98 thyroid/parathyroid:5.95 adrenal gland:6.38 pancreas:6.36 breast:6.48 salivary:6.53
CAGE uterus:3.57 placenta:3.21 prostate:3.30 ovary:3.13 testis:2.67 heart:3.26 muscle:2.62 esophagus:3.36 stomach:- intestine:3.55 colon:3.34     liver/hepato:3.91    lung:3.41 bladder:3.06 kidney:3.52 pituitary:3.18 thyroid/parathyroid:2.92 adrenal gland:- pancreas:2.98 breast:2.95 salivary:4.27
RNA-seq uterus:- placenta:- prostate:1.58 ovary:2.02 testis:1.99 heart:1.42 muscle:0.56 esophagus:- stomach:- intestine:- colon:2.30     liver/hepato:2.76        lung:1.43    bladder:- kidney:3.03 pituitary:- thyroid/parathyroid:1.84 adrenal gland:1.96 pancreas:- breast:3.15 salivary:-

Gene Information

IDs

Refseq ID NM_002223
Gene ID 3709
Unigene ID Hs.512235
Probe set ID 211360_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000123104
GTEx ID ENSG00000123104

Orthologous Gene

Mouse[16]  NM_010586, NM_019923
Rat [0]  

Chromosomal Region

12p11.23  [26,490,342  -  26,986,131]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

1693919
8081734
9729462
10828023
10843712
10874040
10970773
11013462
11163362
11336651
11413485
11694504
11782428
14684825
15342556
16344560
17437169
17827064
18249094
18519826
18936250
19120137
19193627
19464757
19549843
19590686
19913121
19946888
20379614
20395455
20427533
20628086
20935629
21063100
21139048
21555518
21762810
21852551
21890473
21963094
22010048
23131553
23582047
23955339
23983250
24415751

Gene Ontology  (GO ID)

Biological Process

GO:0007202  activation of phospholipase C activity
GO:0007596  blood coagulation
GO:0071320  cellular response to cAMP
GO:0071361  cellular response to ethanol
GO:0006112  energy reserve metabolic process
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0008543  fibroblast growth factor receptor signaling pathway
GO:0045087  innate immune response
GO:0048011  nerve growth factor receptor signaling pathway
GO:0030168  platelet activation
GO:0050796  regulation of insulin secretion
GO:0001666  response to hypoxia
GO:0007165  signal transduction
GO:0006810  transport

Cellular Component

GO:0005938  cell cortex
GO:0005789  endoplasmic reticulum membrane
GO:0016021  integral to membrane
GO:0005886  plasma membrane
GO:0031095  platelet dense tubular network membrane
GO:0033017  sarcoplasmic reticulum membrane

Molecular Function

GO:0015085  calcium ion transmembrane transporter activity
GO:0005220  inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0035091  phosphoinositide binding