jumonji, AT rich interactive domain 2

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Synonym

Jumonji/ARID domain-containing protein 2, jumonji, AT rich interactive domain 2, jumonji (mouse) homolog, Jumonji protein, JARID2, JMJ

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:12.90 bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:7.14 cerebellum:8.13 brain stem:7.01 corpus callosum/glia:7.26 pineal gland:- peripheral nerve:6.89 spine:6.99 retina:- eye:- artery/aorta:7.17 vein:6.98 lymphnode:7.84 peripheral blood:- spleen:8.08 thymus:8.36 bone marrow:8.09 adipose:7.18 bone:- skin:7.73
CAGE cerebrum:3.86 cerebellum:- brain stem:3.65 corpus callosum/glia:4.02 pineal gland:4.97 peripheral nerve:- spine:3.67 retina:- eye:- artery/aorta:3.64 vein:4.06 lymphnode:4.10 peripheral blood:- spleen:3.99 thymus:4.86 bone marrow:- adipose:3.76 bone:- skin:-
RNA-seq cerebrum:2.41 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.24 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.26 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:7.25 placenta:6.72 prostate:6.89 ovary:6.96 testis:8.19 heart:6.95 muscle:7.21 esophagus:8.04 stomach:7.31 intestine:6.90 colon:7.29 liver/hepato:6.94 lung:7.23 bladder:- kidney:6.97 pituitary:6.82 thyroid/parathyroid:7.01 adrenal gland:7.27 pancreas:6.54 breast:7.85 salivary:7.32
CAGE uterus:3.53 placenta:3.27 prostate:3.00 ovary:3.18 testis:3.55 heart:3.10 muscle:3.56 esophagus:3.50 stomach:- intestine:3.86 colon:3.78     liver/hepato:2.35    lung:3.72 bladder:3.29 kidney:3.00 pituitary:3.35 thyroid/parathyroid:2.45 adrenal gland:- pancreas:2.98 breast:2.99 salivary:3.87
RNA-seq uterus:- placenta:- prostate:1.72 ovary:1.81 testis:3.91 heart:2.15 muscle:1.29 esophagus:- stomach:- intestine:- colon:1.57     liver/hepato:1.03        lung:1.91    bladder:- kidney:1.35 pituitary:- thyroid/parathyroid:1.66 adrenal gland:2.33 pancreas:- breast:1.98 salivary:-

Gene Information

IDs

Refseq ID NM_004973
Gene ID 3720
Unigene ID Hs.630189
Probe set ID 203297_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000008083
GTEx ID ENSG00000008083

Orthologous Gene

Mouse[3]  NM_001205043, NM_001205044, NM_021878
Rat[3]  NM_001205043, NM_001205044, NM_021878

Chromosomal Region

6p22.3  [15,245,734  -  15,522,252]

Gene Family (Interpro ID)

IPR003347  Transcription factor jumonji/aspartyl beta-hydroxylase

Link to Pubmed  (Pubmed ID)

8894700
10807864
10913339
12477932
12890668
14574404
15057990
15174051
15489334
15542826
16967465
18805276
19010785
19010793
19322201
19759154
19884986
20075857
20123894
22110129
22116950
22190018
22215809
23294540
23349640
23435416
24374312
24457600
24462204

Gene Ontology  (GO ID)

Biological Process

GO:0007417  central nervous system development
GO:0001889  liver development
GO:0008285  negative regulation of cell proliferation
GO:0031061  negative regulation of histone methylation
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0051574  positive regulation of histone H3-K9 methylation
GO:0048536  spleen development
GO:0048863  stem cell differentiation
GO:0048538  thymus development
GO:0006351  transcription, DNA-dependent

Cellular Component

GO:0035098  ESC/E(Z) complex
GO:0035097  histone methyltransferase complex
GO:0005634  nucleus

Molecular Function

GO:0003682  chromatin binding
GO:0003677  DNA binding
GO:0032452  histone demethylase activity