potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2

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Synonym

KCa2.2, KCNN2, SKCA2, SK2, hSK2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:11.90 cerebellum:12.60 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:5.90 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:12.80 skin:4.80
GeneChip cerebrum:5.35 cerebellum:5.67 brain stem:5.51 corpus callosum/glia:5.63 pineal gland:- peripheral nerve:5.51 spine:7.19 retina:- eye:- artery/aorta:3.64 vein:3.99 lymphnode:3.90 peripheral blood:- spleen:3.47 thymus:3.33 bone marrow:3.51 adipose:3.59 bone:- skin:3.65
CAGE cerebrum:3.05 cerebellum:- brain stem:2.65 corpus callosum/glia:3.09 pineal gland:2.98 peripheral nerve:- spine:2.75 retina:- eye:- artery/aorta:0.59 vein:0.34 lymphnode:0.62 peripheral blood:- spleen:0.76 thymus:0.28 bone marrow:- adipose:0.36 bone:- skin:-
RNA-seq cerebrum:1.04 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.47 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.14 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:45.10 ovary:- testis:8.70 heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:10.40 pituitary:- thyroid/parathyroid:- adrenal gland:101.60 pancreas:- breast:- salivary:-
GeneChip uterus:4.17 placenta:3.21 prostate:7.11 ovary:3.64 testis:4.14 heart:5.02 muscle:4.46 esophagus:3.72 stomach:3.53 intestine:3.64 colon:3.63 liver/hepato:7.18 lung:3.85 bladder:- kidney:4.05 pituitary:5.97 thyroid/parathyroid:3.28 adrenal gland:7.74 pancreas:4.08 breast:3.48 salivary:3.48
CAGE uterus:1.02 placenta:0.24 prostate:2.58 ovary:0.52 testis:1.72 heart:1.41 muscle:0.09 esophagus:0.90 stomach:- intestine:0.14 colon:0.76     liver/hepato:2.31    lung:1.17 bladder:1.32 kidney:0.67 pituitary:3.64 thyroid/parathyroid:0.28 adrenal gland:- pancreas:1.87 breast:0 salivary:0.62
RNA-seq uterus:- placenta:- prostate:1.58 ovary:0.29 testis:0.81 heart:1.88 muscle:0.14 esophagus:- stomach:- intestine:- colon:1.10     liver/hepato:1.28        lung:0.66    bladder:- kidney:0.37 pituitary:- thyroid/parathyroid:0.27 adrenal gland:0.35 pancreas:- breast:0.31 salivary:-

Gene Information

IDs

Refseq ID NM_021614
Gene ID 3781
Unigene ID Hs.98280
Probe set ID 220116_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000080709
GTEx ID ENSG00000080709

Orthologous Gene

Mouse[1]  NM_080465
Rat [0]  

Chromosomal Region

5q22.3  [113,696,666  -  113,832,321]

Gene Family (Interpro ID)

IPR011996  Potassium channel, calcium-activated, SK, conserved region
IPR003931  Potassium channel, calcium-activated, SK, conserved region, subgroup

Link to Pubmed  (Pubmed ID)

10559207
10713270
10758170
10991935
11146124
11323678
11395478
11527975
12477932
12778407
13679367
14702039
15362045
16382103
16396931
17110593
17452806
19139040
19815520
20972266
21906983
22154908
23251661
23525437
23602568
23677057

Gene Ontology  (GO ID)

Biological Process

GO:0006813  potassium ion transport
GO:0007268  synaptic transmission

Cellular Component

GO:0016021  integral to membrane
GO:0005886  plasma membrane

Molecular Function

GO:0051393  alpha-actinin binding
GO:0015269  calcium-activated potassium channel activity
GO:0005516  calmodulin binding
GO:0042803  protein homodimerization activity
GO:0016286  small conductance calcium-activated potassium channel activity