hairy and enhancer of split 5 (Drosophila)

 jump to detail

Synonym

HES5, hairy and enhancer of split 5 (Drosophila)

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:5.90 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:29.40 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip nodata
CAGE cerebrum:2.33 cerebellum:- brain stem:1.13 corpus callosum/glia:1.51 pineal gland:1.07 peripheral nerve:- spine:0.86 retina:- eye:- artery/aorta:1.68 vein:1.23 lymphnode:0.41 peripheral blood:- spleen:0.45 thymus:0.46 bone marrow:- adipose:0.46 bone:- skin:-
RNA-seq cerebrum:0.08 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.02 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.06 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:38.30 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:10.40 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip nodata
CAGE uterus:1.22 placenta:0.68 prostate:1.58 ovary:0.47 testis:1.13 heart:1.48 muscle:0.05 esophagus:0.97 stomach:- intestine:0.57 colon:1.81     liver/hepato:0.71    lung:0.52 bladder:0.64 kidney:0.15 pituitary:0.79 thyroid/parathyroid:0.28 adrenal gland:- pancreas:0.58 breast:2.02 salivary:0.36
RNA-seq uterus:- placenta:- prostate:0.41 ovary:0.10 testis:0.52 heart:0.23 muscle:0.11 esophagus:- stomach:- intestine:- colon:0.13     liver/hepato:0.11        lung:0.11    bladder:- kidney:0.02 pituitary:- thyroid/parathyroid:0 adrenal gland:0.17 pancreas:- breast:0.08 salivary:-

Gene Information

IDs

Refseq ID NM_001010926
Gene ID 388585
Unigene ID Hs.57971
Probe set ID -
Ensembl ID ENSG00000197921
GTEx ID ENSG00000197921

Orthologous Gene

Mouse[2]  NM_010419
Rat [0]  

Chromosomal Region

1p36.32  [2,460,184  -  2,461,684]

Gene Family (Interpro ID)

IPR003650  Orange
IPR018352  Orange subgroup

Link to Pubmed  (Pubmed ID)

12477932
15156153
15254753
16214363
16365048
16710414
17072841
17093926
17388915
17611704
17849174
18354251
18524252
19682396
19855400
20091184
20972266
21238798
21495212
23637910
23776410

Gene Ontology  (GO ID)

Biological Process

GO:0048708  astrocyte differentiation
GO:0042491  auditory receptor cell differentiation
GO:0042668  auditory receptor cell fate determination
GO:0007420  brain development
GO:0043010  camera-type eye development
GO:0051216  cartilage development
GO:0007155  cell adhesion
GO:0048469  cell maturation
GO:0002062  chondrocyte differentiation
GO:0021781  glial cell fate commitment
GO:0022010  myelination in the central nervous system
GO:0048712  negative regulation of astrocyte differentiation
GO:0045665  negative regulation of neuron differentiation
GO:0048715  negative regulation of oligodendrocyte differentiation
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0021915  neural tube development
GO:0007219  Notch signaling pathway
GO:0014003  oligodendrocyte development
GO:0030513  positive regulation of BMP signaling pathway
GO:0008284  positive regulation of cell proliferation
GO:0046427  positive regulation of JAK-STAT cascade
GO:0045747  positive regulation of Notch signaling pathway
GO:0048661  positive regulation of smooth muscle cell proliferation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0042517  positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0006461  protein complex assembly
GO:0021861  radial glial cell differentiation in the forebrain
GO:0045595  regulation of cell differentiation
GO:0031641  regulation of myelination
GO:0050767  regulation of neurogenesis
GO:0007224  smoothened signaling pathway
GO:0021537  telencephalon development

Cellular Component

GO:0005575  cellular_component
GO:0005654  nucleoplasm

Molecular Function

GO:0003682  chromatin binding
GO:0003690  double-stranded DNA binding
GO:0046983  protein dimerization activity
GO:0008134  transcription factor binding