leptin

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Synonym

OB, LEP, Obese protein, leptin (obesity homolog, mouse), OBS, Obesity factor, leptin (murine obesity homolog), Leptin precursor

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:18.20 spleen:- thymus:12.90 bone marrow:- adipose:80.70 bone:- skin:4.80
GeneChip cerebrum:4.09 cerebellum:4.05 brain stem:4.07 corpus callosum/glia:4.04 pineal gland:- peripheral nerve:4.02 spine:4.10 retina:- eye:- artery/aorta:5.57 vein:4.37 lymphnode:4.15 peripheral blood:- spleen:4 thymus:3.73 bone marrow:4.44 adipose:7.93 bone:- skin:5.74
CAGE cerebrum:0.00 cerebellum:- brain stem:0 corpus callosum/glia:0 pineal gland:0 peripheral nerve:- spine:0 retina:- eye:- artery/aorta:0.95 vein:1.98 lymphnode:0.80 peripheral blood:- spleen:0 thymus:0 bone marrow:- adipose:4.81 bone:- skin:-
RNA-seq cerebrum:0.05 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.26 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.38 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:21.90 prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:8.50     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:27.90 salivary:-
GeneChip uterus:3.94 placenta:7.67 prostate:3.88 ovary:4.09 testis:4.02 heart:4.92 muscle:4.39 esophagus:3.96 stomach:4.04 intestine:3.95 colon:4.38 liver/hepato:4.09 lung:4 bladder:- kidney:4.17 pituitary:4.12 thyroid/parathyroid:3.97 adrenal gland:4.39 pancreas:4.38 breast:6.34 salivary:4.11
CAGE uterus:0.07 placenta:3.79 prostate:0 ovary:0.20 testis:0.12 heart:0.86 muscle:0.59 esophagus:0 stomach:- intestine:0.14 colon:0.59     liver/hepato:0    lung:0.34 bladder:1.38 kidney:0.15 pituitary:0 thyroid/parathyroid:0.17 adrenal gland:- pancreas:0 breast:4.79 salivary:0
RNA-seq uterus:- placenta:- prostate:0.17 ovary:0.14 testis:0.57 heart:0.80 muscle:0 esophagus:- stomach:- intestine:- colon:0.47     liver/hepato:0.01        lung:0.05    bladder:- kidney:0.08 pituitary:- thyroid/parathyroid:0.62 adrenal gland:0.30 pancreas:- breast:8.53 salivary:-

IDs

Refseq ID NM_000230
Gene ID 3952
Unigene ID Hs.194236
Probe set ID 207092_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000174697
GTEx ID ENSG00000174697

Orthologous Gene

Mouse[1]  NM_008493
Rat [0]  

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

3952
1686014
7499240
7789654
7984236
8608603
8621021
8626726
8717050
9144295
9166907
9202122
9205417
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Gene Ontology  (GO ID)

Biological Process

GO:0060612  adipose tissue development
GO:0008343  adult feeding behavior
GO:0008206  bile acid metabolic process
GO:0071298  cellular response to L-ascorbic acid
GO:0071300  cellular response to retinoic acid
GO:0021954  central nervous system neuron development
GO:0008203  cholesterol metabolic process
GO:0007623  circadian rhythm
GO:0042755  eating behavior
GO:0006112  energy reserve metabolic process
GO:0009062  fatty acid catabolic process
GO:0007565  female pregnancy
GO:0006006  glucose metabolic process
GO:0006114  glycerol biosynthetic process
GO:0042445  hormone metabolic process
GO:0030073  insulin secretion
GO:0033210  leptin-mediated signaling pathway
GO:0050901  leukocyte tethering or rolling
GO:0043066  negative regulation of apoptosis
GO:0032099  negative regulation of appetite
GO:0070093  negative regulation of glucagon secretion
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045906  negative regulation of vasoconstriction
GO:0001542  ovulation from ovarian follicle
GO:0001890  placenta development
GO:0008284  positive regulation of cell proliferation
GO:0001819  positive regulation of cytokine production
GO:0048639  positive regulation of developmental growth
GO:0046881  positive regulation of follicle-stimulating hormone secretion
GO:0046628  positive regulation of insulin receptor signaling pathway
GO:0043270  positive regulation of ion transport
GO:0033686  positive regulation of luteinizing hormone secretion
GO:0043410  positive regulation of MAPKKK cascade
GO:0045639  positive regulation of myeloid cell differentiation
GO:0042517  positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0008217  regulation of blood pressure
GO:0006111  regulation of gluconeogenesis
GO:0050796  regulation of insulin secretion
GO:0030300  regulation of intestinal cholesterol absorption
GO:0060587  regulation of lipoprotein lipid oxidation
GO:0050810  regulation of steroid biosynthetic process
GO:0002021  response to dietary excess
GO:0001666  response to hypoxia
GO:0032868  response to insulin stimulus
GO:0033197  response to vitamin E
GO:0007260  tyrosine phosphorylation of STAT protein

Cellular Component

GO:0005737  cytoplasm
GO:0005576  extracellular region
GO:0005615  extracellular space

Molecular Function

GO:0008083  growth factor activity
GO:0005179  hormone activity
GO:0051428  peptide hormone receptor binding