ligase IV, DNA, ATP-dependent

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Synonym

ligase IV, DNA, ATP-dependent, DNA ligase 4, LIG4, Polydeoxyribonucleotide synthase [ATP] 4, DNA ligase IV

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:30.80

cerebellum:37.80

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:30.70

spine:-

retina:-

eye:11.80

artery/aorta:-

vein:-

lymphnode:30.30

peripheral blood:18.20

spleen:18.90

thymus:64.40

bone marrow:-

adipose:-

bone:-

skin:19.20

GeneChip

cerebrum:4.89

cerebellum:5.12

brain stem:4.85

corpus callosum/glia:4.81

pineal gland:-

peripheral nerve:4.28

spine:4.76

retina:-

eye:-

artery/aorta:4.08

vein:4.36

lymphnode:4

peripheral blood:-

spleen:4.20

thymus:6.62

bone marrow:4.26

adipose:4.18

bone:-

skin:4.14

CAGE

cerebrum:2.68

cerebellum:-

brain stem:2.92

corpus callosum/glia:2.51

pineal gland:3.21

peripheral nerve:-

spine:2.74

retina:-

eye:-

artery/aorta:1.33

vein:1.92

lymphnode:1.58

peripheral blood:-

spleen:2.55

thymus:2.67

bone marrow:-

adipose:2.34

bone:-

skin:-

RNA-seq

cerebrum:1.53

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0.97

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:1.33

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:7.30

prostate:11.30

ovary:-

testis:13

heart:-

muscle:-

esophagus:-

stomach:106.20

intestine:-

colon:-

liver/hepato:31.70

lung:14.70

bladder:-

kidney:-

pituitary:116

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:27.90

salivary:-

GeneChip

uterus:4.35

placenta:3.96

prostate:4.23

ovary:4.36

testis:4.31

heart:4.35

muscle:4.54

esophagus:4.14

stomach:4.21

intestine:4.44

colon:4.21

liver/hepato:4.62

lung:4.19

bladder:-

kidney:4.10

pituitary:4.51

thyroid/parathyroid:3.91

adrenal gland:4.10

pancreas:4.13

breast:4.14

salivary:4.11

CAGE

uterus:1.68

placenta:2.17

prostate:2.11

ovary:2.04

testis:2.14

heart:1.93

muscle:1.67

esophagus:2.21

stomach:-

intestine:2.26

colon:1.41

liver/hepato:2.68

lung:1.92

bladder:1.96

kidney:2.46

pituitary:3.09

thyroid/parathyroid:2.11

adrenal gland:-

pancreas:0.94

breast:2.41

salivary:1.00

RNA-seq

uterus:-

placenta:-

prostate:0.45

ovary:0.42

testis:0.83

heart:1.43

muscle:1.52

esophagus:-

stomach:-

intestine:-

colon:0.85

liver/hepato:0.44

lung:1.40

bladder:-

kidney:0.46

pituitary:-

thyroid/parathyroid:1.19

adrenal gland:1.25

pancreas:-

breast:0.80

salivary:-

IDs

Refseq ID	NM_002312
Gene ID	3981
Unigene ID	Hs.166091
Probe set ID	206235_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000174405
GTEx ID	ENSG00000174405

Orthologous Gene

Mouse[1]	NM_176953
Rat [0]

Chromosomal Region

13q33.3 [108,859,794 - 108,870,716]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

LRG_79 [5,753 - 13,093]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR012310

ATP dependent DNA ligase, central

Gene Ontology (GO ID)

Biological Process

GO:0007049	cell cycle
GO:0051301	cell division
GO:0008283	cell proliferation
GO:0071285	cellular response to lithium ion
GO:0007417	central nervous system development
GO:0051276	chromosome organization
GO:0006266	DNA ligation
GO:0051102	DNA ligation during DNA recombination
GO:0051103	DNA ligation during DNA repair
GO:0006281	DNA repair
GO:0006302	double-strand break repair
GO:0006303	double-strand break repair via nonhomologous end joining
GO:0033152	immunoglobulin V(D)J recombination
GO:0001701	in utero embryonic development
GO:0045190	isotype switching
GO:0006273	lagging strand elongation
GO:0043524	negative regulation of neuron apoptosis
GO:0051402	neuron apoptosis
GO:0006297	nucleotide-excision repair, DNA gap filling
GO:0048146	positive regulation of fibroblast proliferation
GO:0050769	positive regulation of neurogenesis
GO:0002328	pro-B cell differentiation
GO:0010332	response to gamma radiation
GO:0010165	response to X-ray
GO:0000012	single strand break repair
GO:0035019	somatic stem cell maintenance
GO:0033077	T cell differentiation in the thymus
GO:0033153	T cell receptor V(D)J recombination
GO:0033151	V(D)J recombination
GO:0016032	viral reproduction

Cellular Component

GO:0000793	condensed chromosome
GO:0005737	cytoplasm
GO:0032807	DNA ligase IV complex
GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex
GO:0005925	focal adhesion
GO:0070419	nonhomologous end joining complex
GO:0005730	nucleolus
GO:0005654	nucleoplasm
GO:0005634	nucleus
GO:0005886	plasma membrane

Molecular Function

GO:0005524	ATP binding
GO:0003677	DNA binding
GO:0003910	DNA ligase (ATP) activity
GO:0003909	DNA ligase activity
GO:0016874	ligase activity
GO:0046872	metal ion binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding

ligase IV, DNA, ATP-dependent

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function