low density lipoprotein receptor-related protein 4

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Synonym

low density lipoprotein receptor-related protein 4, KIAA0816, Multiple epidermal growth factor-like domains 7, MEGF7, LRP4, LRP10

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:22.50 cerebellum:63 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:118.60 eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:14.40
GeneChip cerebrum:7.56 cerebellum:6.15 brain stem:7.15 corpus callosum/glia:7.74 pineal gland:- peripheral nerve:6.39 spine:7.79 retina:- eye:- artery/aorta:5.39 vein:5.23 lymphnode:5.08 peripheral blood:- spleen:6.48 thymus:5.04 bone marrow:5.13 adipose:5.24 bone:- skin:6.79
CAGE cerebrum:3.45 cerebellum:- brain stem:3.03 corpus callosum/glia:3.51 pineal gland:1.09 peripheral nerve:- spine:3.39 retina:- eye:- artery/aorta:1.57 vein:1.44 lymphnode:0.62 peripheral blood:- spleen:1.26 thymus:0.77 bone marrow:- adipose:1.33 bone:- skin:-
RNA-seq cerebrum:3.98 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.73 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.54 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:27.90 salivary:-
GeneChip uterus:5.41 placenta:5.14 prostate:5.66 ovary:5.30 testis:5.03 heart:5.55 muscle:5.73 esophagus:5.54 stomach:5.86 intestine:5.92 colon:5.96 liver/hepato:4.93 lung:5.91 bladder:- kidney:5.12 pituitary:5.53 thyroid/parathyroid:5.42 adrenal gland:5.94 pancreas:5.41 breast:5.78 salivary:5.15
CAGE uterus:1.66 placenta:0.85 prostate:1.42 ovary:1.43 testis:1.35 heart:2.03 muscle:2.22 esophagus:1.20 stomach:- intestine:1.96 colon:2.47     liver/hepato:0.46    lung:1.60 bladder:0.98 kidney:1.01 pituitary:1.49 thyroid/parathyroid:1.15 adrenal gland:- pancreas:0.94 breast:0.90 salivary:1.28
RNA-seq uterus:- placenta:- prostate:0.98 ovary:1.80 testis:0.81 heart:1.89 muscle:2.78 esophagus:- stomach:- intestine:- colon:1.29     liver/hepato:0.46        lung:1.54    bladder:- kidney:0.46 pituitary:- thyroid/parathyroid:2.06 adrenal gland:0.61 pancreas:- breast:0.68 salivary:-

Gene Information

IDs

Refseq ID NM_002334
Gene ID 4038
Unigene ID Hs.493037
Probe set ID 212850_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000134569
GTEx ID ENSG00000134569

Orthologous Gene

Mouse[4]  NM_001145857, NM_172668
Rat[1]  NM_031322, NM_172668

Chromosomal Region

11p11.2  [46,878,419  -  46,940,193]

Gene Family (Interpro ID)

IPR001881  EGF-like calcium-binding
IPR000742  EGF-like, type 3

Link to Pubmed  (Pubmed ID)

9693030
12421765
12477932
15489334
16344560
16517118
16554811
17549794
17620599
19079262
20005200
20205790
20381006
20554715
20686565
21471202
21502573
21645651
21890473
21969364
22794264
23321396
23664847
24097068
24297891

Gene Ontology  (GO ID)

Biological Process

GO:0009953  dorsal/ventral pattern formation
GO:0042733  embryonic digit morphogenesis
GO:0006897  endocytosis
GO:0030198  extracellular matrix organization
GO:0001942  hair follicle development
GO:0001822  kidney development
GO:0030279  negative regulation of ossification
GO:0090090  negative regulation of Wnt receptor signaling pathway through beta-catenin
GO:0042475  odontogenesis of dentine-containing tooth
GO:0009954  proximal/distal pattern formation
GO:0043113  receptor clustering
GO:0001932  regulation of protein amino acid phosphorylation
GO:0051124  synaptic growth at neuromuscular junction
GO:0016055  Wnt receptor signaling pathway

Cellular Component

GO:0005575  cellular_component
GO:0016021  integral to membrane
GO:0005886  plasma membrane

Molecular Function

GO:0005509  calcium ion binding
GO:0005515  protein binding
GO:0042803  protein homodimerization activity
GO:0030971  receptor tyrosine kinase binding