low density lipoprotein receptor-related protein 5

Synonym

LRP5, OPS, osteoporosis pseudoglioma syndrome, low density lipoprotein receptor-related protein 5, LR3, exudative vitreoretinopathy 1, EVR4, EVR1, BMND1, VBCH2, LRP7, HBM, OPTA1, OPPG

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:-

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

GeneChip

cerebrum:3.91

cerebellum:3.52

brain stem:3.84

corpus callosum/glia:4.18

pineal gland:-

peripheral nerve:4.43

spine:4.07

retina:-

eye:-

artery/aorta:5.97

vein:5.16

lymphnode:4.67

peripheral blood:-

spleen:4.49

thymus:4.18

bone marrow:4.10

adipose:5.49

bone:-

skin:4.78

CAGE

cerebrum:1.17

cerebellum:-

brain stem:1.25

corpus callosum/glia:1.92

pineal gland:0.14

peripheral nerve:-

spine:1.45

retina:-

eye:-

artery/aorta:3.68

vein:2.31

lymphnode:1.91

peripheral blood:-

spleen:1.12

thymus:2.13

bone marrow:-

adipose:2.75

bone:-

skin:-

RNA-seq

cerebrum:0.55

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:2.72

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:3.70

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:-

prostate:-

ovary:-

testis:8.70

heart:-

muscle:-

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:-

lung:-

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

GeneChip

uterus:5.07

placenta:5.11

prostate:5.17

ovary:5.36

testis:4.02

heart:5.61

muscle:4.26

esophagus:4.86

stomach:6.03

intestine:5.53

colon:6.07

liver/hepato:7.02

lung:5.93

bladder:-

kidney:6.18

pituitary:5.11

thyroid/parathyroid:6.14

adrenal gland:6.29

pancreas:4.84

breast:5.77

salivary:6.90

CAGE

uterus:2.67

placenta:2.55

prostate:2.73

ovary:2.54

testis:1.56

heart:2.67

muscle:1.99

esophagus:2.29

stomach:-

intestine:3.22

colon:3.18

liver/hepato:3.58

lung:2.66

bladder:2.28

kidney:2.57

pituitary:1.66

thyroid/parathyroid:2.89

adrenal gland:-

pancreas:3.50

breast:3.38

salivary:3.37

RNA-seq

uterus:-

placenta:-

prostate:3.35

ovary:3.66

testis:2.66

heart:2.40

muscle:1.61

esophagus:-

stomach:-

intestine:-

colon:3.38

liver/hepato:3.74

lung:2.49

bladder:-

kidney:2.61

pituitary:-

thyroid/parathyroid:3.43

adrenal gland:3.23

pancreas:-

breast:4.08

salivary:-

IDs

Refseq ID	NM_002335
Gene ID	4041
Unigene ID	Hs.634720
Probe set ID	209468_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000162337
GTEx ID	ENSG00000162337

Orthologous Gene

Mouse[1]	NM_008513
Rat[1]	NM_001106321

Chromosomal Region

11q13.2 [68,080,077 - 68,216,743]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

Gene Ontology (GO ID)

Biological Process

GO:0060612	adipose tissue development
GO:0009952	anterior/posterior pattern formation
GO:0048539	bone marrow development
GO:0060349	bone morphogenesis
GO:0046849	bone remodeling
GO:0060444	branching involved in mammary gland duct morphogenesis
GO:0042632	cholesterol homeostasis
GO:0048596	embryonic camera-type eye morphogenesis
GO:0030326	embryonic limb morphogenesis
GO:0060059	embryonic retina morphogenesis in camera-type eye
GO:0006897	endocytosis
GO:0001702	gastrulation with mouth forming second
GO:0006007	glucose catabolic process
GO:0045668	negative regulation of osteoblast differentiation
GO:0002076	osteoblast development
GO:0008284	positive regulation of cell proliferation
GO:0045600	positive regulation of fat cell differentiation
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0045840	positive regulation of mitosis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045893	positive regulation of transcription, DNA-dependent
GO:0008217	regulation of blood pressure
GO:0060828	regulation of Wnt receptor signaling pathway through beta-catenin
GO:0060042	retina morphogenesis in camera-type eye
GO:0016055	Wnt receptor signaling pathway
GO:0060070	Wnt receptor signaling pathway through beta-catenin

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0016021	integral to membrane
GO:0005886	plasma membrane
GO:0043235	receptor complex

Molecular Function

GO:0015026	coreceptor activity
GO:0005515	protein binding
GO:0019534	toxin transporter activity
GO:0042813	Wnt receptor activity
GO:0017147	Wnt-protein binding

low density lipoprotein receptor-related protein 5

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function