lymphotoxin beta (TNF superfamily, member 3)

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Synonym

lymphotoxin beta (TNF superfamily, member 3), TNF-C, TNFSF3, Lymphotoxin-beta, Tumor necrosis factor C, TNFC, Tumor necrosis factor ligand superfamily member 3, LTB, LT-beta

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:4.70 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:293.20 peripheral blood:54.70 spleen:151.30 thymus:103.10 bone marrow:19.70 adipose:- bone:25.60 skin:-
GeneChip cerebrum:6.08 cerebellum:6.22 brain stem:6.25 corpus callosum/glia:5.95 pineal gland:- peripheral nerve:5.55 spine:5.65 retina:- eye:- artery/aorta:6.13 vein:6.51 lymphnode:9.93 peripheral blood:- spleen:10.40 thymus:9.92 bone marrow:7.68 adipose:6.95 bone:- skin:6.56
CAGE cerebrum:0.02 cerebellum:- brain stem:0.13 corpus callosum/glia:0 pineal gland:0 peripheral nerve:- spine:0 retina:- eye:- artery/aorta:1.22 vein:4.80 lymphnode:4.54 peripheral blood:- spleen:4.63 thymus:5.22 bone marrow:- adipose:0.46 bone:- skin:-
RNA-seq cerebrum:0.35 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:5.82 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.13 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:18.20 prostate:- ovary:- testis:4.30 heart:- muscle:- esophagus:- stomach:- intestine:32.40 colon:8.50     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:6.13 placenta:5.80 prostate:5.86 ovary:6.24 testis:5.42 heart:6.40 muscle:6.28 esophagus:6.17 stomach:7.03 intestine:6.58 colon:7.03 liver/hepato:6.51 lung:7.12 bladder:- kidney:6.24 pituitary:5.84 thyroid/parathyroid:6.46 adrenal gland:6.22 pancreas:6.54 breast:6.41 salivary:6.32
CAGE uterus:0.57 placenta:0.59 prostate:1.16 ovary:0.92 testis:0.62 heart:0.47 muscle:0.17 esophagus:2.10 stomach:- intestine:1.95 colon:1.95     liver/hepato:1.12    lung:2.16 bladder:1.58 kidney:1.61 pituitary:0 thyroid/parathyroid:0.06 adrenal gland:- pancreas:1.21 breast:0.90 salivary:2.50
RNA-seq uterus:- placenta:- prostate:1.27 ovary:0.70 testis:0.32 heart:0.00 muscle:0.30 esophagus:- stomach:- intestine:- colon:0.31     liver/hepato:0.42        lung:2.22    bladder:- kidney:0.86 pituitary:- thyroid/parathyroid:0.58 adrenal gland:7.34 pancreas:- breast:0.97 salivary:-

Gene Information

IDs

Refseq ID NM_009588
Gene ID 4050
Unigene ID Hs.376208
Probe set ID 207339_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000204487
ENSG00000206437
ENSG00000223448
ENSG00000227507
ENSG00000231314
ENSG00000236237
ENSG00000236925
ENSG00000238114
GTEx ID ENSG00000204487
ENSG00000206437
ENSG00000223448
ENSG00000227507
ENSG00000231314
ENSG00000236237
ENSG00000236925
ENSG00000238114

Orthologous Gene

Mouse[1]  NM_008518
Rat[1]  NM_212507

Chromosomal Region

HSCHR6_MHC_APD  [31,559,653  -  31,561,620]
6p21.33  [31,548,302  -  31,550,299]
HSCHR6_MHC_SSTO  [31,538,275  -  31,540,242]
HSCHR6_MHC_MANN  [31,587,819  -  31,589,786]
HSCHR6_MHC_QBL  [31,538,575  -  31,540,542]
HSCHR6_MHC_MCF  [31,624,641  -  31,626,608]
HSCHR6_MHC_DBB  [31,530,476  -  31,532,443]
HSCHR6_MHC_COX  [31,535,744  -  31,537,711]

Gene Family (Interpro ID)

IPR006052  Tumor Necrosis Factor
IPR006053  Tumor necrosis factor alpha/beta/c
IPR002961  Tumour necrosis factor c/lymphotoxin-beta
IPR008983  Tumour necrosis factor-like

Link to Pubmed  (Pubmed ID)

1670638
1671667
1714477
2995927
7590964
7601445
7916655
7995952
8081366
8499947
8586432
8629302
8824804
9185077
9235946
9299492
9317127
9480751
9545284
10202016
10318773
10668961
11823516
12474234
12477932
14656967
15034048
15077289
15248211
15489334
15910501
15969671
16702430
17981284
18292573
18379788
19115949
19222863
19729601
19735075
19800575
19851445
19913121
19948975
20356761
20628086
20662065
21029472
21102463
21211989
21248773
22294627
22652080
22742857

Gene Ontology  (GO ID)

Biological Process

GO:0007267  cell-cell signaling
GO:0010467  gene expression
GO:0006955  immune response
GO:0048535  lymph node development
GO:0045084  positive regulation of interleukin-12 biosynthetic process
GO:0007165  signal transduction
GO:0043588  skin development

Cellular Component

GO:0005575  cellular_component
GO:0005615  extracellular space
GO:0016021  integral to membrane

Molecular Function

GO:0005125  cytokine activity
GO:0005102  receptor binding
GO:0005164  tumor necrosis factor receptor binding