arrestin, beta 2

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Synonym

ARB2, Arrestin beta 2, ARRB2, arrestin, beta 2, DKFZp686L0365, Beta-arrestin-2, ARR2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:78.20 cerebellum:37.80 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:61.30 spine:- retina:- eye:70.50 artery/aorta:30 vein:- lymphnode:222.40 peripheral blood:200.40 spleen:94.50 thymus:90.20 bone marrow:373.90 adipose:80.70 bone:64 skin:91.20
GeneChip cerebrum:6.69 cerebellum:6.78 brain stem:6.75 corpus callosum/glia:6.74 pineal gland:- peripheral nerve:6.70 spine:6.88 retina:- eye:- artery/aorta:6.15 vein:6.06 lymphnode:6.91 peripheral blood:- spleen:7.14 thymus:6.48 bone marrow:8.24 adipose:6.51 bone:- skin:6.21
CAGE cerebrum:4.03 cerebellum:- brain stem:4.16 corpus callosum/glia:4.22 pineal gland:3.33 peripheral nerve:- spine:3.87 retina:- eye:- artery/aorta:3.41 vein:3.94 lymphnode:4.09 peripheral blood:- spleen:4.80 thymus:3.93 bone marrow:- adipose:4.23 bone:- skin:-
RNA-seq cerebrum:2.13 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.94 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.19 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:51 prostate:- ovary:- testis:21.60 heart:25.50 muscle:80.40 esophagus:- stomach:85 intestine:- colon:42.40     liver/hepato:52.80        lung:53.80    bladder:- kidney:20.80 pituitary:116 thyroid/parathyroid:- adrenal gland:- pancreas:26.70 breast:- salivary:-
GeneChip uterus:5.86 placenta:5.98 prostate:5.43 ovary:6.03 testis:5.55 heart:6.12 muscle:5.51 esophagus:5.97 stomach:6.28 intestine:6.43 colon:6.43 liver/hepato:6.54 lung:7.36 bladder:- kidney:5.95 pituitary:6.20 thyroid/parathyroid:5.85 adrenal gland:6.32 pancreas:6.06 breast:6.26 salivary:5.78
CAGE uterus:3.24 placenta:3.36 prostate:3.30 ovary:3.43 testis:2.72 heart:3.31 muscle:2.76 esophagus:3.11 stomach:- intestine:4.15 colon:3.33     liver/hepato:3.44    lung:4.30 bladder:3.48 kidney:3.34 pituitary:3.08 thyroid/parathyroid:2.73 adrenal gland:- pancreas:2.66 breast:2.99 salivary:3.03
RNA-seq uterus:- placenta:- prostate:0.00 ovary:1.92 testis:2.04 heart:0.02 muscle:0.80 esophagus:- stomach:- intestine:- colon:1.44     liver/hepato:1.08        lung:0.00    bladder:- kidney:0.00 pituitary:- thyroid/parathyroid:1.65 adrenal gland:4.07 pancreas:- breast:1.93 salivary:-

Gene Information

IDs

Refseq ID NM_199004
Gene ID 409
Unigene ID Hs.435811
Probe set ID 203388_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000141480
GTEx ID ENSG00000141480

Orthologous Gene

Mouse[2]  NM_145429
Rat [0]  

Chromosomal Region

17p13.2  [4,613,784  -  4,624,795]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

1517224
1587386
7695743
8486659
9037196
9169477
9346876
9668034
10097102
10644702
10858453
11090355
11226259
11259507
11279203
11356842
11533043
11535606
11588219
11729201
11867621
11877451
12070169
12105416
12186555
12370187
12393857
12464600
12473660
12477932
12488444
12538596
12574160
12582207
12654503
12949261
12958364
12958365
14500724
14702039
14711824
14769794
15125834
15173580
15231748
15355986
15361545
15364949
15489220
15489334
15528268
15611106
15618519
15626751
15634674
15635042
15687500
15699045
15699339
15728711
15782195
15817468
15878855
15888437
16038799
16051150
16103897
16169070
16181421
16308565
16325578
16378096
16513835
16524428
16580177
16605244
16611986
16689683
16820410
16894395
16956790
16968782
17005854
17038311
17233643
17256744
17272726
17353931
17377064
17500066
17540773
17565992
17579607
17620599
17713785
17761157
17846866
17855543
17947233
17978999
17984062
18006496
18036556
18039931
18191226
18408005
18435604
18445652
18544533
18604210
18621717
18691971
18703513
18768750
18787115
18801735
18802075
18937294
18940181
19008961
19049562
19060904
19071087
19165858
19171933
19188335
19202075
19219857
19239323
19262695
19279230
19306926
19363159
19372219
19416857
19424180
19453261
19458261
19531493
19730683
19782076
19794961
19846537
19874574
20035620
20056609
20100572
20228252
20360068
20457218
20478633
20497256
20505072
20514076
20656684
20734064
20801186
20864483
20936779
21081496
21112970
21152433
21256133
21258807
21296876
21306178
21318602
21321125
21378163
21389118
21466165
21502318
21589858
21642958
21644508
21645452
21708946
21833475
21890473
21906983
21952200
21988832
22006018
22190034
22242112
22333895
22369787
22472784
22523395
22562249
22610101
22735336
22773819
22871966
23011268
23069267
23077507
23139825
23188799
23208550
23236378
23266473
23290307
23297229
23302795
23341447
23382074
23449980
23527545
23541635
23782696
23818521
23820308
23985900
24056371
24069330
24157794
24169548
24250222
24265322
24561123
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0007628  adult walking behavior
GO:0007596  blood coagulation
GO:0007420  brain development
GO:0060326  cell chemotaxis
GO:0002032  desensitization of G-protein coupled receptor protein signaling pathway by arrestin
GO:0050965  detection of temperature stimulus involved in sensory perception of pain
GO:0042699  follicle-stimulating hormone signaling pathway
GO:0002031  G-protein coupled receptor internalization
GO:0034260  negative regulation of GTPase activity
GO:0032691  negative regulation of interleukin-1 beta production
GO:0032695  negative regulation of interleukin-12 production
GO:0032715  negative regulation of interleukin-6 production
GO:0045953  negative regulation of natural killer cell mediated cytotoxicity
GO:0032088  negative regulation of NF-kappaB transcription factor activity
GO:0031397  negative regulation of protein ubiquitination
GO:0034392  negative regulation of smooth muscle cell apoptosis
GO:0034122  negative regulation of toll-like receptor signaling pathway
GO:0032720  negative regulation of tumor necrosis factor production
GO:0007219  Notch signaling pathway
GO:0030168  platelet activation
GO:0051928  positive regulation of calcium ion transport
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0050731  positive regulation of peptidyl-tyrosine phosphorylation
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0031398  positive regulation of protein ubiquitination
GO:0002092  positive regulation of receptor internalization
GO:0032226  positive regulation of synaptic transmission, dopaminergic
GO:0043161  proteasomal ubiquitin-dependent protein catabolic process
GO:0015031  protein transport
GO:0016567  protein ubiquitination
GO:0031623  receptor internalization
GO:0060765  regulation of androgen receptor signaling pathway
GO:0006366  transcription from RNA polymerase II promoter
GO:0007179  transforming growth factor beta receptor signaling pathway

Cellular Component

GO:0016323  basolateral plasma membrane
GO:0005905  coated pit
GO:0005737  cytoplasm
GO:0016023  cytoplasmic membrane-bounded vesicle
GO:0031410  cytoplasmic vesicle
GO:0005829  cytosol
GO:0043197  dendritic spine
GO:0005634  nucleus
GO:0005886  plasma membrane
GO:0014069  postsynaptic density
GO:0045211  postsynaptic membrane

Molecular Function

GO:0031691  alpha-1A adrenergic receptor binding
GO:0031692  alpha-1B adrenergic receptor binding
GO:0031701  angiotensin receptor binding
GO:0031748  D1 dopamine receptor binding
GO:0031762  follicle stimulating hormone receptor binding
GO:0001664  G-protein-coupled receptor binding
GO:0051019  mitogen-activated protein kinase binding
GO:0005515  protein binding
GO:0032403  protein complex binding
GO:0032947  protein complex scaffold
GO:0019904  protein domain specific binding
GO:0043422  protein kinase B binding
GO:0005102  receptor binding
GO:0031702  type 1 angiotensin receptor binding
GO:0031826  type 2A serotonin receptor binding
GO:0031625  ubiquitin protein ligase binding