Mdm2 p53 binding protein homolog (mouse)

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Synonym

p53-binding protein Mdm2, Ubiquitin-protein ligase E3 Mdm2, hdm2, HDMX, MGC71221, MDM2, Hdm2, HDM2, Double minute 2 protein, Oncoprotein Mdm2

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:35.60 cerebellum:12.60 brain stem:- corpus callosum/glia:204.10 pineal gland:- peripheral nerve:30.70 spine:- retina:118.60 eye:58.80 artery/aorta:- vein:- lymphnode:131.40 peripheral blood:309.70 spleen:170.20 thymus:12.90 bone marrow:39.40 adipose:- bone:76.80 skin:129.60
GeneChip cerebrum:3.86 cerebellum:3.74 brain stem:3.94 corpus callosum/glia:3.83 pineal gland:- peripheral nerve:3.74 spine:3.97 retina:- eye:- artery/aorta:3.96 vein:3.92 lymphnode:3.92 peripheral blood:- spleen:3.83 thymus:5.01 bone marrow:4.16 adipose:4.08 bone:- skin:4.24
CAGE cerebrum:3.90 cerebellum:- brain stem:4.12 corpus callosum/glia:4.14 pineal gland:3.78 peripheral nerve:- spine:4.03 retina:- eye:- artery/aorta:4.06 vein:4.05 lymphnode:4.05 peripheral blood:- spleen:4.22 thymus:4.67 bone marrow:- adipose:4.34 bone:- skin:-
RNA-seq cerebrum:3.36 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.20 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.74 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:91.10 placenta:171.20 prostate:123.90 ovary:223.60 testis:34.60 heart:25.50 muscle:60.30 esophagus:- stomach:106.20 intestine:64.80 colon:25.40     liver/hepato:105.60        lung:205.30    bladder:125.60 kidney:311.90 pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:71.10 breast:- salivary:-
GeneChip uterus:4.21 placenta:4.20 prostate:4.23 ovary:4.10 testis:3.64 heart:3.81 muscle:3.82 esophagus:3.97 stomach:4.04 intestine:4.22 colon:4.46 liver/hepato:3.98 lung:3.74 bladder:- kidney:3.99 pituitary:3.93 thyroid/parathyroid:3.74 adrenal gland:3.74 pancreas:4.25 breast:3.88 salivary:3.74
CAGE uterus:3.88 placenta:4.59 prostate:4.00 ovary:3.93 testis:3.57 heart:3.87 muscle:4.40 esophagus:3.89 stomach:- intestine:3.55 colon:3.74     liver/hepato:4.00    lung:4.40 bladder:4.11 kidney:3.63 pituitary:3.96 thyroid/parathyroid:3.63 adrenal gland:- pancreas:3.80 breast:3.92 salivary:3.15
RNA-seq uterus:- placenta:- prostate:3.38 ovary:3.85 testis:3.20 heart:2.77 muscle:4.07 esophagus:- stomach:- intestine:- colon:2.72     liver/hepato:3.13        lung:3.26    bladder:- kidney:3.51 pituitary:- thyroid/parathyroid:3.71 adrenal gland:3.39 pancreas:- breast:3.63 salivary:-

IDs

Refseq ID NM_002392
Gene ID 4193
Unigene ID Hs.484551
Probe set ID 217373_x_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000135679
GTEx ID ENSG00000135679

Orthologous Gene

Mouse[2]  NM_010786
Rat[3]  NM_001108099

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

1535557
1614537
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Gene Ontology  (GO ID)

Biological Process

GO:0071229  cellular response to acid
GO:0071312  cellular response to alkaloid
GO:0071236  cellular response to antibiotic
GO:0071391  cellular response to estrogen stimulus
GO:0070301  cellular response to hydrogen peroxide
GO:0071456  cellular response to hypoxia
GO:0071375  cellular response to peptide hormone stimulus
GO:0071494  cellular response to UV-C
GO:0071301  cellular response to vitamin B1
GO:0006977  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0045184  establishment of protein localization
GO:0008543  fibroblast growth factor receptor signaling pathway
GO:0045087  innate immune response
GO:0043066  negative regulation of apoptosis
GO:0043154  negative regulation of caspase activity
GO:0071157  negative regulation of cell cycle arrest
GO:0043518  negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0010955  negative regulation of protein maturation by peptide bond cleavage
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0048011  nerve growth factor receptor signaling pathway
GO:0018205  peptidyl-lysine modification
GO:0048015  phosphoinositide-mediated signaling
GO:0008284  positive regulation of cell proliferation
GO:0010628  positive regulation of gene expression
GO:0045931  positive regulation of mitotic cell cycle
GO:0032436  positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0046827  positive regulation of protein export from nucleus
GO:0006461  protein complex assembly
GO:0031648  protein destabilization
GO:0034504  protein localization in nucleus
GO:0016567  protein ubiquitination
GO:0042787  protein ubiquitination during ubiquitin-dependent protein catabolic process
GO:0042176  regulation of protein catabolic process
GO:0046677  response to antibiotic
GO:0009743  response to carbohydrate stimulus
GO:0042220  response to cocaine
GO:0042493  response to drug
GO:0045472  response to ether
GO:0010039  response to iron ion
GO:0032026  response to magnesium ion
GO:0043278  response to morphine
GO:0007268  synaptic transmission
GO:0007089  traversing start control point of mitotic cell cycle
GO:0019048  virus-host interaction

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0030666  endocytic vesicle membrane
GO:0016604  nuclear body
GO:0005730  nucleolus
GO:0005654  nucleoplasm
GO:0005634  nucleus
GO:0005886  plasma membrane
GO:0043234  protein complex
GO:0045202  synapse

Molecular Function

GO:0019899  enzyme binding
GO:0042802  identical protein binding
GO:0002039  p53 binding
GO:0042975  peroxisome proliferator activated receptor binding
GO:0005515  protein binding
GO:0004842  ubiquitin-protein ligase activity
GO:0008270  zinc ion binding