malic enzyme 1, NADP(+)-dependent, cytosolic

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Synonym

NADP-dependent malic enzyme, malic enzyme 1, NADP(+)-dependent, cytosolic, MES, Malic enzyme 1, HUMNDME, NADP-ME, ME1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:5.08 cerebellum:3.77 brain stem:5.98 corpus callosum/glia:4.44 pineal gland:- peripheral nerve:6.83 spine:5.83 retina:- eye:- artery/aorta:4.72 vein:4.33 lymphnode:3.99 peripheral blood:- spleen:3.04 thymus:3.42 bone marrow:3.05 adipose:6.28 bone:- skin:5.49
CAGE cerebrum:3.67 cerebellum:- brain stem:3.61 corpus callosum/glia:3.15 pineal gland:4.78 peripheral nerve:- spine:3.85 retina:- eye:- artery/aorta:3.59 vein:3.43 lymphnode:3.12 peripheral blood:- spleen:3.08 thymus:2.08 bone marrow:- adipose:3.99 bone:- skin:-
RNA-seq cerebrum:3.55 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.48 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.63 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:3.89 placenta:3.81 prostate:4.42 ovary:3.98 testis:5.41 heart:4.77 muscle:5.99 esophagus:5.70 stomach:4.25 intestine:4.42 colon:3.22 liver/hepato:4.10 lung:3.44 bladder:- kidney:2.93 pituitary:5.50 thyroid/parathyroid:3.72 adrenal gland:6.22 pancreas:3.33 breast:4.67 salivary:2.86
CAGE uterus:2.85 placenta:1.47 prostate:3.46 ovary:3.16 testis:3.80 heart:3.93 muscle:3.64 esophagus:3.76 stomach:- intestine:3.52 colon:2.91     liver/hepato:3.68    lung:3.57 bladder:4.00 kidney:2.61 pituitary:3.72 thyroid/parathyroid:2.64 adrenal gland:- pancreas:2.60 breast:4.16 salivary:2.01
RNA-seq uterus:- placenta:- prostate:4.50 ovary:3.62 testis:3.61 heart:3.27 muscle:3.49 esophagus:- stomach:- intestine:- colon:2.77     liver/hepato:2.84        lung:2.71    bladder:- kidney:2.53 pituitary:- thyroid/parathyroid:4.15 adrenal gland:2.71 pancreas:- breast:5.88 salivary:-

Gene Information

IDs

Refseq ID NM_002395
Gene ID 4199
Unigene ID Hs.211600
Probe set ID 204058_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000065833
GTEx ID ENSG00000065833

Orthologous Gene

Mouse[4]  NM_001198933, NM_008615
Rat [0]  

Chromosomal Region

6q14.2  [83,920,108  -  84,140,797]

Gene Family (Interpro ID)

IPR012302  Malic enzyme, NAD-binding
IPR016040  NAD(P)-binding domain

Link to Pubmed  (Pubmed ID)

1088824
2015102
3169368
4689040
7496989
7622060
7757881
8125298
8187880
8804575
9174159
11085912
11352855
11358520
12121650
12477932
14574404
15489334
16344560
16757477
18029348
18660489
19293334
19416979
19464998
20877624
21139048
21555518
21890473
21906983
21963094
22456781
22863883
23114090
23284632
23334421
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0005975  carbohydrate metabolic process
GO:0044255  cellular lipid metabolic process
GO:0006108  malate metabolic process
GO:0006741  NADP biosynthetic process
GO:0051262  protein tetramerization
GO:0009743  response to carbohydrate stimulus
GO:0009725  response to hormone stimulus

Cellular Component

GO:0005829  cytosol
GO:0005739  mitochondrion

Molecular Function

GO:0043531  ADP binding
GO:0009055  electron carrier activity
GO:0004473  malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity
GO:0016619  malate dehydrogenase (oxaloacetate-decarboxylating) activity
GO:0004470  malic enzyme activity
GO:0030145  manganese ion binding
GO:0051287  NAD or NADH binding
GO:0050661  NADP or NADPH binding