mitogen-activated protein kinase kinase kinase 11

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Synonym

SPRK, MLK3, MLK-3, MAP3K11, mitogen-activated protein kinase kinase kinase 11, PTK1, Mitogen-activated protein kinase kinase kinase 11, MGC17114, Mixed lineage kinase 3

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:100.70 cerebellum:314.80 brain stem:- corpus callosum/glia:58.30 pineal gland:- peripheral nerve:- spine:112.30 retina:- eye:47 artery/aorta:30 vein:66.60 lymphnode:131.40 peripheral blood:164 spleen:226.90 thymus:180.40 bone marrow:- adipose:40.30 bone:12.80 skin:9.60
GeneChip cerebrum:7.16 cerebellum:6.48 brain stem:7.18 corpus callosum/glia:7.84 pineal gland:- peripheral nerve:7.68 spine:7.36 retina:- eye:- artery/aorta:7.63 vein:6.87 lymphnode:7.77 peripheral blood:- spleen:8.12 thymus:7.18 bone marrow:7.25 adipose:7.59 bone:- skin:7.29
CAGE cerebrum:2.57 cerebellum:- brain stem:3.32 corpus callosum/glia:3.69 pineal gland:1.56 peripheral nerve:- spine:2.91 retina:- eye:- artery/aorta:2.59 vein:2.56 lymphnode:2.86 peripheral blood:- spleen:3.14 thymus:2.39 bone marrow:- adipose:2.99 bone:- skin:-
RNA-seq cerebrum:2.46 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.88 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.33 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:82 placenta:72.90 prostate:56.30 ovary:- testis:51.90 heart:25.50 muscle:- esophagus:- stomach:- intestine:64.80 colon:50.90     liver/hepato:10.60        lung:73.30    bladder:- kidney:52 pituitary:- thyroid/parathyroid:- adrenal gland:101.60 pancreas:35.60 breast:37.20 salivary:-
GeneChip uterus:6.91 placenta:6.64 prostate:6.84 ovary:6.79 testis:7 heart:6.89 muscle:6.41 esophagus:6.97 stomach:7.34 intestine:7.01 colon:7.47 liver/hepato:7.93 lung:7.84 bladder:- kidney:7.42 pituitary:7.09 thyroid/parathyroid:7.39 adrenal gland:7.37 pancreas:6.87 breast:7.52 salivary:7.15
CAGE uterus:2.67 placenta:2.76 prostate:2.82 ovary:2.52 testis:2.79 heart:2.92 muscle:1.59 esophagus:2.99 stomach:- intestine:3.58 colon:2.86     liver/hepato:3.52    lung:3.27 bladder:2.38 kidney:2.68 pituitary:2.18 thyroid/parathyroid:2.50 adrenal gland:- pancreas:2.60 breast:3.64 salivary:1.58
RNA-seq uterus:- placenta:- prostate:3.33 ovary:2.91 testis:3.14 heart:2.21 muscle:2.16 esophagus:- stomach:- intestine:- colon:3.35     liver/hepato:3.80        lung:4.72    bladder:- kidney:3.38 pituitary:- thyroid/parathyroid:3.31 adrenal gland:3.93 pancreas:- breast:3.68 salivary:-

Gene Information

IDs

Refseq ID NM_002419
Gene ID 4296
Unigene ID Hs.502872
Probe set ID 203652_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000173327
GTEx ID ENSG00000173327

Orthologous Gene

Mouse[1]  NM_022012
Rat[1]  NM_001013150

Chromosomal Region

11q13.1  [65,365,226  -  65,382,853]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

8125298
8183572
8195146
9267807
9427749
9430657
9829970
10187804
10490659
10629060
10713178
10799501
11053428
11152698
11306803
11590155
11713255
11784851
11969422
12190962
12354290
12376551
12458207
12477932
12504027
12529434
12917434
14504284
14702039
15001580
15069087
15258589
15489334
15923109
16253996
16344560
16456539
16537381
16687404
16964243
17192257
17584736
17711861
18222647
18624398
18851832
19546888
19586614
19782705
19946888
19955118
20145118
20150185
20158498
20368287
20514022
20890305
20936779
20937558
21880738
21979919
21988832
22078707
22118674
22139075
22509080
22566623
22652451
22700880
22761715
23172226
23857585
23906792
24044867

Gene Ontology  (GO ID)

Biological Process

GO:0007257  activation of JUN kinase activity
GO:0000187  activation of MAPK activity
GO:0008219  cell death
GO:0008283  cell proliferation
GO:0000080  G1 phase of mitotic cell cycle
GO:0007254  JNK cascade
GO:0007017  microtubule-based process
GO:0046330  positive regulation of JNK cascade
GO:0043507  positive regulation of JUN kinase activity
GO:0043525  positive regulation of neuron apoptosis
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation

Cellular Component

GO:0005813  centrosome
GO:0005737  cytoplasm
GO:0005874  microtubule

Molecular Function

GO:0005524  ATP binding
GO:0042802  identical protein binding
GO:0004706  JUN kinase kinase kinase activity
GO:0031434  mitogen-activated protein kinase kinase binding
GO:0031435  mitogen-activated protein kinase kinase kinase binding
GO:0005515  protein binding
GO:0042803  protein homodimerization activity
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0004713  protein tyrosine kinase activity
GO:0048365  Rac GTPase binding