metallothionein 3

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Synonym

Metallothionein-3, MT-III, Growth inhibitory factor, GRIF, Metallothionein-III, MT-3, GIFB, MT3

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:111.40 cerebellum:63 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:23.50 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip nodata
CAGE cerebrum:6.38 cerebellum:- brain stem:5.97 corpus callosum/glia:5.55 pineal gland:4.12 peripheral nerve:- spine:5.70 retina:- eye:- artery/aorta:1.38 vein:1.98 lymphnode:0.80 peripheral blood:- spleen:0.25 thymus:0.46 bone marrow:- adipose:0.96 bone:- skin:-
RNA-seq cerebrum:7.83 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.34 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.38 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:- breast:- salivary:-
GeneChip nodata
CAGE uterus:0.73 placenta:0.08 prostate:1.21 ovary:0.64 testis:1.51 heart:1.47 muscle:1.02 esophagus:1.64 stomach:- intestine:0.33 colon:1.82     liver/hepato:0    lung:0.14 bladder:1.47 kidney:0.82 pituitary:2.31 thyroid/parathyroid:0.45 adrenal gland:- pancreas:0 breast:0 salivary:3.08
RNA-seq uterus:- placenta:- prostate:1.92 ovary:0.26 testis:2.94 heart:0.98 muscle:0.80 esophagus:- stomach:- intestine:- colon:2.88     liver/hepato:0.15        lung:1.39    bladder:- kidney:0.93 pituitary:- thyroid/parathyroid:0.11 adrenal gland:0.30 pancreas:- breast:0.12 salivary:-

Gene Information

IDs

Refseq ID NM_005954
Gene ID 4504
Unigene ID Hs.73133
Probe set ID -
Ensembl ID ENSG00000087250
GTEx ID ENSG00000087250

Orthologous Gene

Mouse[1]  NM_013603
Rat [0]  

Chromosomal Region

16q12.2  [56,623,184  -  56,625,000]

Gene Family (Interpro ID)

IPR003019  Metallothionein superfamily, eukaryotic
IPR000006  Metallothionein, vertebrate

Link to Pubmed  (Pubmed ID)

1464312
1631128
1873033
2071148
7677777
8039715
8751715
9655243
10355541
10517878
11226237
11849386
11994011
12058024
12067712
12072966
12111700
12187490
12383939
12477932
12538345
12539042
12763630
15129022
15190073
15489334
16036436
16087360
16336778
16351731
16387743
16546755
16601975
16712791
16945328
17712581
18029348
18157556
18182399
18206644
18208603
18295594
18533104
18554677
18757100
18782281
19425569
19490120
19536566
19578815
19881214
20039155
20646067
20974010
21044950
21818286
22615124
23086305
23482768
23728617
23794209
24222235

Gene Ontology  (GO ID)

Biological Process

GO:0032148  activation of protein kinase B activity
GO:0014002  astrocyte development
GO:0055073  cadmium ion homeostasis
GO:0008283  cell proliferation
GO:0044242  cellular lipid catabolic process
GO:0006875  cellular metal ion homeostasis
GO:0071276  cellular response to cadmium ion
GO:0071456  cellular response to hypoxia
GO:0034599  cellular response to oxidative stress
GO:0006882  cellular zinc ion homeostasis
GO:0006707  cholesterol catabolic process
GO:0006112  energy reserve metabolic process
GO:0070371  ERK1 and ERK2 cascade
GO:0016570  histone modification
GO:0033210  leptin-mediated signaling pathway
GO:0043066  negative regulation of apoptosis
GO:0010507  negative regulation of autophagy
GO:0030517  negative regulation of axon extension
GO:0043154  negative regulation of caspase activity
GO:0030308  negative regulation of cell growth
GO:0060547  negative regulation of necrotic cell death
GO:0043524  negative regulation of neuron apoptosis
GO:0051354  negative regulation of oxidoreductase activity
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0043085  positive regulation of catalytic activity
GO:0010942  positive regulation of cell death
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0010628  positive regulation of gene expression
GO:0010940  positive regulation of necrotic cell death
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0030949  positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0000060  protein import into nucleus, translocation
GO:0043491  protein kinase B signaling cascade
GO:0050821  protein stabilization
GO:0060049  regulation of protein amino acid glycosylation
GO:0032095  regulation of response to food
GO:0019430  removal of superoxide radicals
GO:0001666  response to hypoxia
GO:0055069  zinc ion homeostasis
GO:0006829  zinc ion transport

Cellular Component

GO:0005737  cytoplasm
GO:0016234  inclusion body
GO:0005622  intracellular
GO:0048471  perinuclear region of cytoplasm
GO:0008021  synaptic vesicle

Molecular Function

GO:0016209  antioxidant activity
GO:0046870  cadmium ion binding
GO:0043027  caspase inhibitor activity
GO:0005507  copper ion binding
GO:0008144  drug binding
GO:0005515  protein binding
GO:0030295  protein kinase activator activity
GO:0008270  zinc ion binding