5-methyltetrahydrofolate-homocysteine methyltransferase reductase

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Synonym

MSR, MGC129643, MTRR

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:77

cerebellum:50.40

brain stem:-

corpus callosum/glia:58.30

pineal gland:-

peripheral nerve:61.30

spine:-

retina:-

eye:11.80

artery/aorta:30

vein:-

lymphnode:30.30

peripheral blood:91.10

spleen:37.80

thymus:90.20

bone marrow:59

adipose:-

bone:64

skin:67.20

GeneChip

cerebrum:4.76

cerebellum:4.34

brain stem:4.90

corpus callosum/glia:5

pineal gland:-

peripheral nerve:4.35

spine:4.74

retina:-

eye:-

artery/aorta:4.52

vein:4.67

lymphnode:4.34

peripheral blood:-

spleen:4.36

thymus:4.33

bone marrow:4.20

adipose:4.64

bone:-

skin:4.42

CAGE

cerebrum:3.17

cerebellum:-

brain stem:3.45

corpus callosum/glia:3.72

pineal gland:3.51

peripheral nerve:-

spine:3.36

retina:-

eye:-

artery/aorta:2.97

vein:2.69

lymphnode:2.88

peripheral blood:-

spleen:2.84

thymus:2.58

bone marrow:-

adipose:2.84

bone:-

skin:-

RNA-seq

cerebrum:2.02

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0.00

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:2.54

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:82

placenta:51

prostate:33.80

ovary:-

testis:116.80

heart:25.50

muscle:60.30

esophagus:-

stomach:-

intestine:64.80

colon:42.40

liver/hepato:73.90

lung:88

bladder:125.60

kidney:62.40

pituitary:116

thyroid/parathyroid:-

adrenal gland:-

pancreas:35.60

breast:18.60

salivary:-

GeneChip

uterus:4.63

placenta:4.46

prostate:4.65

ovary:4.53

testis:4.53

heart:4.92

muscle:5.11

esophagus:4.18

stomach:4.69

intestine:4.84

colon:4.60

liver/hepato:4.68

lung:4.68

bladder:-

kidney:4.83

pituitary:4.56

thyroid/parathyroid:4.16

adrenal gland:4.65

pancreas:4.42

breast:4.41

salivary:4.46

CAGE

uterus:3.27

placenta:2.75

prostate:3.09

ovary:3.22

testis:3.14

heart:2.83

muscle:3.36

esophagus:2.69

stomach:-

intestine:2.99

colon:2.77

liver/hepato:3.53

lung:3.43

bladder:3.16

kidney:3.32

pituitary:3.26

thyroid/parathyroid:3.22

adrenal gland:-

pancreas:3.13

breast:2.53

salivary:3.13

RNA-seq

uterus:-

placenta:-

prostate:1.29

ovary:3.12

testis:3.00

heart:0.29

muscle:3.64

esophagus:-

stomach:-

intestine:-

colon:2.77

liver/hepato:0.90

lung:2.38

bladder:-

kidney:2.00

pituitary:-

thyroid/parathyroid:1.80

adrenal gland:1.59

pancreas:-

breast:1.63

salivary:-

IDs

Refseq ID	NM_002454
Gene ID	4552
Unigene ID	Hs.481551
Probe set ID	203199_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000124275
GTEx ID	ENSG00000124275

Orthologous Gene

Mouse[1]	NM_172480
Rat[1]	NM_001039003

Chromosomal Region

5p15.31 [7,851,299 - 7,906,138]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR001094	Flavodoxin-like
IPR008254	Flavodoxin/nitric oxide synthase
IPR001709	Flavoprotein pyridine nucleotide cytochrome reductase

Gene Ontology (GO ID)

Biological Process

GO:0034641	cellular nitrogen compound metabolic process
GO:0009235	cobalamin metabolic process
GO:0009086	methionine biosynthetic process
GO:0006555	methionine metabolic process
GO:0032259	methylation
GO:0055114	oxidation reduction
GO:0000096	sulfur amino acid metabolic process
GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0006805	xenobiotic metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0045111	intermediate filament cytoskeleton
GO:0005730	nucleolus
GO:0005634	nucleus

Molecular Function

GO:0050660	FAD binding
GO:0010181	FMN binding
GO:0005506	iron ion binding
GO:0050661	NADP or NADPH binding
GO:0003958	NADPH-hemoprotein reductase activity
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
GO:0016723	oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor
GO:0030586	[methionine synthase] reductase activity

5-methyltetrahydrofolate-homocysteine methyltransferase reductase

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function