myosin, heavy chain 6, cardiac muscle, alpha

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Synonym

ASD3, Myosin heavy chain, cardiac muscle alpha isoform, MyHC-alpha, alpha-MHC, MYHCA, MYH6, heavy polypeptide 6, MYHC

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:29.60 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:245.40 spine:- retina:- eye:5.90 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:403.30 bone:- skin:110.40
GeneChip cerebrum:4.40 cerebellum:4.34 brain stem:4.40 corpus callosum/glia:4.31 pineal gland:- peripheral nerve:4.38 spine:4.27 retina:- eye:- artery/aorta:6.29 vein:8.30 lymphnode:4.62 peripheral blood:- spleen:4.33 thymus:4.60 bone marrow:4.64 adipose:4.47 bone:- skin:5.44
CAGE cerebrum:0.01 cerebellum:- brain stem:0 corpus callosum/glia:0 pineal gland:0 peripheral nerve:- spine:0 retina:- eye:- artery/aorta:0 vein:0.96 lymphnode:0 peripheral blood:- spleen:0 thymus:0 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:0.05 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.20 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.01 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:3.60 prostate:135.20 ovary:- testis:4.30 heart:2771.50 muscle:8638.90 esophagus:- stomach:- intestine:- colon:-     liver/hepato:21.10        lung:53.80    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:8.90 breast:9.30 salivary:-
GeneChip uterus:4.42 placenta:4.34 prostate:4.60 ovary:4.57 testis:4.50 heart:10.42 muscle:8.83 esophagus:5.98 stomach:4.39 intestine:5.30 colon:4.47 liver/hepato:4.40 lung:4.38 bladder:- kidney:4.41 pituitary:5.39 thyroid/parathyroid:4.32 adrenal gland:5.98 pancreas:4.71 breast:4.42 salivary:4.62
CAGE uterus:0 placenta:0 prostate:0.15 ovary:0 testis:0 heart:5.04 muscle:1.68 esophagus:0.33 stomach:- intestine:0 colon:0     liver/hepato:0    lung:0 bladder:0 kidney:0 pituitary:0 thyroid/parathyroid:0.90 adrenal gland:- pancreas:0 breast:0 salivary:0
RNA-seq uterus:- placenta:- prostate:0.03 ovary:0.04 testis:1.79 heart:8.08 muscle:5.01 esophagus:- stomach:- intestine:- colon:0.01     liver/hepato:0.04        lung:0    bladder:- kidney:0.00 pituitary:- thyroid/parathyroid:3.76 adrenal gland:0.00 pancreas:- breast:2.13 salivary:-

Gene Information

IDs

Refseq ID NM_002471
Gene ID 4624
Unigene ID Hs.278432
Probe set ID 214468_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000197616
GTEx ID ENSG00000197616

Orthologous Gene

Mouse[8]  NM_001164171, NM_010856
Rat [0]  

Chromosomal Region

14q11.2  [23,851,199  -  23,877,486]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

1776652
1930170
1975475
2062315
2144212
2494889
2726733
2969919
3037493
8307559
8424456
9410916
11512664
11815426
12477932
12933792
15621050
15735645
15998695
16088376
16344560
18029348
18029400
18429820
18511944
19801488
19913121
20035047
20062063
20215591
20301486
20301559
20301725
20628086
20639392
20656787
21378987
21436590
22194935
22627578
23183192
23583979
24224850

Gene Ontology  (GO ID)

Biological Process

GO:0007512  adult heart development
GO:0006200  ATP catabolic process
GO:0055009  atrial cardiac muscle tissue morphogenesis
GO:0030509  BMP signaling pathway
GO:0048739  cardiac muscle fiber development
GO:0001701  in utero embryonic development
GO:0006936  muscle contraction
GO:0030049  muscle filament sliding
GO:0030239  myofibril assembly
GO:0043462  regulation of ATPase activity
GO:0008217  regulation of blood pressure
GO:0008016  regulation of heart contraction
GO:0060420  regulation of heart growth
GO:0002027  regulation of heart rate
GO:0002026  regulation of the force of heart contraction
GO:0045214  sarcomere organization
GO:0006941  striated muscle contraction
GO:0055010  ventricular cardiac muscle tissue morphogenesis
GO:0007522  visceral muscle development
GO:0060070  Wnt receptor signaling pathway through beta-catenin

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005925  focal adhesion
GO:0005859  muscle myosin complex
GO:0030016  myofibril
GO:0016459  myosin complex
GO:0032982  myosin filament
GO:0005730  nucleolus
GO:0005634  nucleus
GO:0030017  sarcomere
GO:0001725  stress fiber
GO:0030018  Z disc

Molecular Function

GO:0003779  actin binding
GO:0030898  actin-dependent ATPase activity
GO:0005524  ATP binding
GO:0016887  ATPase activity
GO:0005516  calmodulin binding
GO:0000146  microfilament motor activity
GO:0019901  protein kinase binding
GO:0008307  structural constituent of muscle