myosin VI

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Synonym

KIAA0389, myosin VI, Myosin-6, MYO6, DFNB37, Myosin VI, DFNA22

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:55.70 cerebellum:113.30 brain stem:- corpus callosum/glia:58.30 pineal gland:296.70 peripheral nerve:184 spine:224.60 retina:237.30 eye:82.30 artery/aorta:89.90 vein:- lymphnode:10.10 peripheral blood:36.40 spleen:37.80 thymus:- bone marrow:- adipose:- bone:51.20 skin:48
GeneChip cerebrum:7.86 cerebellum:7.12 brain stem:7.79 corpus callosum/glia:8.71 pineal gland:- peripheral nerve:6.93 spine:7.68 retina:- eye:- artery/aorta:6.55 vein:6.20 lymphnode:6.68 peripheral blood:- spleen:6.53 thymus:5.30 bone marrow:4.68 adipose:6.50 bone:- skin:6.69
CAGE cerebrum:4.23 cerebellum:- brain stem:4.39 corpus callosum/glia:4.60 pineal gland:5.51 peripheral nerve:- spine:4.47 retina:- eye:- artery/aorta:3.37 vein:2.57 lymphnode:2.97 peripheral blood:- spleen:2.73 thymus:1.78 bone marrow:- adipose:3.31 bone:- skin:-
RNA-seq cerebrum:3.93 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.97 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.83 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:63.80 placenta:10.90 prostate:157.70 ovary:- testis:121.10 heart:25.50 muscle:40.20 esophagus:- stomach:21.20 intestine:97.20 colon:67.80     liver/hepato:42.20        lung:58.70    bladder:125.60 kidney:873.40 pituitary:- thyroid/parathyroid:- adrenal gland:101.60 pancreas:168.90 breast:185.90 salivary:328.40
GeneChip uterus:6.75 placenta:6.01 prostate:8.01 ovary:6.88 testis:7.26 heart:5.74 muscle:4.49 esophagus:8.11 stomach:7.72 intestine:6.65 colon:5.92 liver/hepato:7.05 lung:7.84 bladder:- kidney:8.19 pituitary:7.66 thyroid/parathyroid:7.08 adrenal gland:6.82 pancreas:6.78 breast:7.75 salivary:6.31
CAGE uterus:3.29 placenta:3.05 prostate:3.56 ovary:2.79 testis:3.72 heart:2.83 muscle:2.56 esophagus:3.60 stomach:- intestine:4.37 colon:3.80     liver/hepato:3.33    lung:4.29 bladder:3.42 kidney:4.69 pituitary:4.44 thyroid/parathyroid:3.44 adrenal gland:- pancreas:3.26 breast:4.10 salivary:3.35
RNA-seq uterus:- placenta:- prostate:3.18 ovary:2.63 testis:3.53 heart:1.32 muscle:0.60 esophagus:- stomach:- intestine:- colon:2.41     liver/hepato:2.11        lung:3.40    bladder:- kidney:4.41 pituitary:- thyroid/parathyroid:3.02 adrenal gland:2.23 pancreas:- breast:2.94 salivary:-

Gene Information

IDs

Refseq ID NM_004999
Gene ID 4646
Unigene ID Hs.149387
Probe set ID 203215_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000196586
GTEx ID ENSG00000196586

Orthologous Gene

Mouse[3]  NM_001039546
Rat[3]  NM_001039546

Chromosomal Region

6q14.1  [76,458,909  -  76,629,254]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

7493015
7929586
8022818
9205841
9259267
9852149
10198040
10519557
11447109
11468689
11517222
11707568
11728438
11906161
11967127
12050163
12477932
12687499
12857860
12893809
14574404
14702039
15044955
15060111
15123708
15146066
15231748
15247260
15837803
16169070
16196087
16335966
16344560
16499958
16507995
16908842
16948370
16949370
17071605
17187061
17353931
17635994
17683200
18029400
18212818
18311135
18348273
18429820
18543251
19056867
19615732
19855435
19893302
19913121
19946888
20161783
20201926
20301607
20353999
20379614
20473970
20576604
20604900
20628086
20850010
20936779
20972266
21139048
21148290
21182205
21278381
21735821
21890473
21906983
21963094
21987572
22053931
22171985
22266860
22268729
22321127
22323290
22884421
22992744
23000965
23023224
23340379
23398456
23503661
23635807
24028494

Gene Ontology  (GO ID)

Biological Process

GO:0030048  actin filament-based movement
GO:0042491  auditory receptor cell differentiation
GO:0071257  cellular response to electrical stimulus
GO:0016358  dendrite development
GO:0030330  DNA damage response, signal transduction by p53 class mediator
GO:0006897  endocytosis
GO:0014047  glutamate secretion
GO:0042472  inner ear morphogenesis
GO:0006886  intracellular protein transport
GO:0007626  locomotory behavior
GO:0016044  membrane organization
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0006605  protein targeting
GO:0051046  regulation of secretion
GO:0048167  regulation of synaptic plasticity
GO:0007605  sensory perception of sound
GO:0007416  synapse assembly
GO:0007268  synaptic transmission

Cellular Component

GO:0030424  axon
GO:0005938  cell cortex
GO:0043025  cell soma
GO:0030665  clathrin coated vesicle membrane
GO:0045334  clathrin-coated endocytic vesicle
GO:0005905  coated pit
GO:0005737  cytoplasm
GO:0016023  cytoplasmic membrane-bounded vesicle
GO:0005829  cytosol
GO:0016591  DNA-directed RNA polymerase II, holoenzyme
GO:0030139  endocytic vesicle
GO:0031941  filamentous actin
GO:0005794  Golgi apparatus
GO:0005765  lysosomal membrane
GO:0031965  nuclear membrane
GO:0005654  nucleoplasm
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane
GO:0001726  ruffle
GO:0032587  ruffle membrane
GO:0016461  unconventional myosin complex

Molecular Function

GO:0003779  actin binding
GO:0051015  actin filament binding
GO:0043531  ADP binding
GO:0005524  ATP binding
GO:0005516  calmodulin binding
GO:0060001  minus-end directed microfilament motor activity
GO:0003774  motor activity
GO:0005515  protein binding