neutrophil cytosolic factor 2

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Synonym

67 kDa neutrophil oxidase factor, Neutrophil NADPH oxidase factor 2, NOXA2, p67phox, chronic granulomatous disease, p67-phox, Neutrophil cytosol factor 2, NCF2, NCF-2, P67-PHOX

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:8.30 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:47 artery/aorta:30 vein:- lymphnode:80.90 peripheral blood:1330 spleen:434.80 thymus:38.70 bone marrow:196.80 adipose:- bone:358.30 skin:4.80
GeneChip cerebrum:4.26 cerebellum:4.12 brain stem:4.39 corpus callosum/glia:4.53 pineal gland:- peripheral nerve:4.37 spine:4.58 retina:- eye:- artery/aorta:4.63 vein:4.52 lymphnode:4.96 peripheral blood:- spleen:7.17 thymus:4.74 bone marrow:8.68 adipose:5 bone:- skin:5.18
CAGE cerebrum:1.17 cerebellum:- brain stem:1.93 corpus callosum/glia:1.78 pineal gland:0.95 peripheral nerve:- spine:2.06 retina:- eye:- artery/aorta:2.28 vein:2.79 lymphnode:3.11 peripheral blood:- spleen:4.02 thymus:1.86 bone marrow:- adipose:3.28 bone:- skin:-
RNA-seq cerebrum:1.60 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.86 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.49 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:61.90 prostate:- ovary:37.30 testis:4.30 heart:- muscle:- esophagus:- stomach:- intestine:32.40 colon:17     liver/hepato:21.10        lung:122.20    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:8.90 breast:37.20 salivary:-
GeneChip uterus:4.24 placenta:5.44 prostate:4.14 ovary:4.29 testis:3.99 heart:4.69 muscle:4.21 esophagus:4.63 stomach:4.56 intestine:4.87 colon:4.63 liver/hepato:4.58 lung:8.18 bladder:- kidney:4.09 pituitary:4.38 thyroid/parathyroid:4.24 adrenal gland:4.16 pancreas:4.66 breast:4.74 salivary:4.59
CAGE uterus:1.39 placenta:2.78 prostate:1.86 ovary:1.80 testis:1.47 heart:2.16 muscle:0.97 esophagus:1.59 stomach:- intestine:1.15 colon:1.27     liver/hepato:2.10    lung:4.35 bladder:1.81 kidney:1.53 pituitary:0.67 thyroid/parathyroid:1.38 adrenal gland:- pancreas:1.87 breast:2.02 salivary:1.58
RNA-seq uterus:- placenta:- prostate:1.86 ovary:2.08 testis:1.92 heart:0.32 muscle:0.79 esophagus:- stomach:- intestine:- colon:2.24     liver/hepato:1.32        lung:4.39    bladder:- kidney:1.45 pituitary:- thyroid/parathyroid:0.38 adrenal gland:2.69 pancreas:- breast:2.96 salivary:-

Gene Information

IDs

Refseq ID NM_001127651
Gene ID 4688
Unigene ID Hs.587558
Probe set ID 209949_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000116701
GTEx ID ENSG00000116701

Orthologous Gene

Mouse[1]  NM_010877
Rat[1]  NM_001100984

Chromosomal Region

1q25.3  [183,524,698  -  183,560,011]
LRG_88  [4,978  -  40,020]

Gene Family (Interpro ID)

IPR019734  Tetratricopeptide repeat

Link to Pubmed  (Pubmed ID)

1692159
1979859
2393022
7738010
7903171
7938008
8036496
8257426
8286749
8748143
8889548
8975869
9070911
9083043
9121467
9255350
9365277
9624165
9642115
9914162
10486263
10498624
10598813
10672014
11027608
11090627
11248021
11278853
11483497
11483614
11705402
11733522
11781392
11796733
11893732
11896062
11917128
11929750
12101222
12121978
12130503
12169629
12207919
12477932
12716910
12719414
12813044
12887891
15181005
15256399
15342556
15489334
15513967
15642721
16052631
16293794
16297854
16310324
16344560
16608528
16626305
16710414
16782902
16987007
17060455
17462995
17537988
17651608
17703412
17712795
17910042
18029348
18029359
18424721
18546332
18625437
18676680
19116138
19170196
19258923
19372141
19423521
19423540
19439231
19505917
19625176
19692168
19717732
19913121
19953534
20056178
20074641
20167518
20237496
20375610
20406964
20438785
20503287
20628086
20679349
20842512
21119665
21900546
21954286
22046141
22203994
22562447
22797925
22876374
23187810
23264412
23821607

Gene Ontology  (GO ID)

Biological Process

GO:0007568  aging
GO:0042590  antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0002479  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002474  antigen processing and presentation of peptide antigen via MHC class I
GO:0006968  cellular defense response
GO:0032870  cellular response to hormone stimulus
GO:0045087  innate immune response
GO:0051701  interaction with host
GO:0045777  positive regulation of blood pressure
GO:0043525  positive regulation of neuron apoptosis
GO:0045730  respiratory burst
GO:0014823  response to activity
GO:0042493  response to drug
GO:0009749  response to glucose stimulus
GO:0055093  response to hyperoxia
GO:0034616  response to laminar fluid shear stress
GO:0032496  response to lipopolysaccharide
GO:0032570  response to progesterone stimulus
GO:0042554  superoxide anion generation
GO:0006801  superoxide metabolic process

Cellular Component

GO:0001669  acrosomal vesicle
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0043020  NADPH oxidase complex
GO:0005730  nucleolus
GO:0032010  phagolysosome

Molecular Function

GO:0009055  electron carrier activity
GO:0005515  protein binding
GO:0008022  protein C-terminus binding
GO:0048365  Rac GTPase binding
GO:0016175  superoxide-generating NADPH oxidase activity