neurofibromin 1

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Synonym

VRNF, WSS, Neurofibromin, NFNS, DKFZp686J1293, NF1, Neurofibromatosis-related protein NF-1

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:51

cerebellum:12.60

brain stem:-

corpus callosum/glia:29.20

pineal gland:148.30

peripheral nerve:-

spine:-

retina:-

eye:117.50

artery/aorta:-

vein:-

lymphnode:70.80

peripheral blood:18.20

spleen:-

thymus:25.80

bone marrow:-

adipose:-

bone:-

skin:62.40

GeneChip

cerebrum:6.57

cerebellum:6.51

brain stem:6.57

corpus callosum/glia:6.74

pineal gland:-

peripheral nerve:6.63

spine:6.85

retina:-

eye:-

artery/aorta:6.13

vein:6.29

lymphnode:5.86

peripheral blood:-

spleen:5.84

thymus:6.55

bone marrow:5.62

adipose:6.02

bone:-

skin:5.92

CAGE

cerebrum:4.63

cerebellum:-

brain stem:4.51

corpus callosum/glia:4.38

pineal gland:4.92

peripheral nerve:-

spine:4.55

retina:-

eye:-

artery/aorta:4.06

vein:3.95

lymphnode:3.22

peripheral blood:-

spleen:3.98

thymus:3.85

bone marrow:-

adipose:3.98

bone:-

skin:-

RNA-seq

cerebrum:3.33

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0.00

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0.01

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:18.20

placenta:18.20

prostate:11.30

ovary:-

testis:21.60

heart:38.30

muscle:-

esophagus:-

stomach:-

intestine:-

colon:17

liver/hepato:-

lung:48.90

bladder:-

kidney:31.20

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:88.90

breast:-

salivary:-

GeneChip

uterus:6.47

placenta:6.74

prostate:6.90

ovary:6.39

testis:5.77

heart:6.36

muscle:5.95

esophagus:5.79

stomach:6.05

intestine:6.23

colon:5.68

liver/hepato:5.87

lung:6.09

bladder:-

kidney:5.93

pituitary:6.17

thyroid/parathyroid:6.65

adrenal gland:6.06

pancreas:6.09

breast:6.39

salivary:6.35

CAGE

uterus:4.15

placenta:4.13

prostate:4.05

ovary:3.92

testis:4.37

heart:4.17

muscle:3.95

esophagus:3.75

stomach:-

intestine:4.07

colon:3.82

liver/hepato:3.81

lung:4.10

bladder:4.12

kidney:4.09

pituitary:4.58

thyroid/parathyroid:4.00

adrenal gland:-

pancreas:3.65

breast:4.10

salivary:3.88

RNA-seq

uterus:-

placenta:-

prostate:1.49

ovary:2.18

testis:2.52

heart:1.06

muscle:2.13

esophagus:-

stomach:-

intestine:-

colon:0.51

liver/hepato:1.84

lung:1.62

bladder:-

kidney:2.53

pituitary:-

thyroid/parathyroid:2.18

adrenal gland:0.96

pancreas:-

breast:1.71

salivary:-

IDs

Refseq ID	NM_000267
Gene ID	4763
Unigene ID	Hs.113577
Probe set ID	212676_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000196712
GTEx ID	ENSG00000196712

Orthologous Gene

Mouse[2]	NM_010897
Rat [0]

Chromosomal Region

17q11.2 [29,421,945 - 29,708,905]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR001936	Ras GTPase-activating protein
IPR008936	Rho GTPase activation protein

Gene Ontology (GO ID)

Biological Process

GO:0030036	actin cytoskeleton organization
GO:0030325	adrenal gland development
GO:0048844	artery morphogenesis
GO:0007420	brain development
GO:0048593	camera-type eye morphogenesis
GO:0007154	cell communication
GO:0021987	cerebral cortex development
GO:0050890	cognition
GO:0030199	collagen fibril organization
GO:0030198	extracellular matrix organization
GO:0021897	forebrain astrocyte development
GO:0048853	forebrain morphogenesis
GO:0007507	heart development
GO:0001889	liver development
GO:0000165	MAPKKK cascade
GO:0001656	metanephros development
GO:0022011	myelination in the peripheral nervous system
GO:0016525	negative regulation of angiogenesis
GO:0048712	negative regulation of astrocyte differentiation
GO:0030336	negative regulation of cell migration
GO:0001953	negative regulation of cell-matrix adhesion
GO:0001937	negative regulation of endothelial cell proliferation
GO:0048147	negative regulation of fibroblast proliferation
GO:0043407	negative regulation of MAP kinase activity
GO:0043409	negative regulation of MAPKKK cascade
GO:0007406	negative regulation of neuroblast proliferation
GO:0046929	negative regulation of neurotransmitter secretion
GO:0048715	negative regulation of oligodendrocyte differentiation
GO:0045671	negative regulation of osteoclast differentiation
GO:0006469	negative regulation of protein kinase activity
GO:0035021	negative regulation of Rac protein signal transduction
GO:0046580	negative regulation of Ras protein signal transduction
GO:0042992	negative regulation of transcription factor import into nucleus
GO:0021915	neural tube development
GO:0001649	osteoblast differentiation
GO:0007422	peripheral nervous system development
GO:0014065	phosphoinositide 3-kinase cascade
GO:0043473	pigmentation
GO:0045762	positive regulation of adenylate cyclase activity
GO:0043065	positive regulation of apoptosis
GO:0001938	positive regulation of endothelial cell proliferation
GO:0043525	positive regulation of neuron apoptosis
GO:0032320	positive regulation of Ras GTPase activity
GO:0007265	Ras protein signal transduction
GO:0045765	regulation of angiogenesis
GO:0043535	regulation of blood vessel endothelial cell migration
GO:0045124	regulation of bone resorption
GO:0001952	regulation of cell-matrix adhesion
GO:0045685	regulation of glial cell differentiation
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0032318	regulation of Ras GTPase activity
GO:0032228	regulation of synaptic transmission, GABAergic
GO:0001666	response to hypoxia
GO:0014044	Schwann cell development
GO:0007519	skeletal muscle tissue development
GO:0048745	smooth muscle tissue development
GO:0021510	spinal cord development
GO:0048485	sympathetic nervous system development
GO:0008542	visual learning
GO:0042060	wound healing

Cellular Component

GO:0030424	axon
GO:0005737	cytoplasm
GO:0030425	dendrite
GO:0031235	intrinsic to internal side of plasma membrane
GO:0005634	nucleus

Molecular Function

GO:0005515	protein binding
GO:0005099	Ras GTPase activator activity

neurofibromin 1

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function