nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

Synonym

LYT10, LYT-10, DNA-binding factor KBF2, NFKB2, H2TF1, Lymphocyte translocation chromosome 10, Lyt10, Nuclear factor NF-kappa-B p100 subunit, Oncogene Lyt-10

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:15.40

cerebellum:12.60

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:41.10

artery/aorta:-

vein:-

lymphnode:80.90

peripheral blood:72.90

spleen:132.30

thymus:141.70

bone marrow:19.70

adipose:40.30

bone:51.20

skin:24

GeneChip

cerebrum:5.34

cerebellum:5.47

brain stem:5.41

corpus callosum/glia:5.33

pineal gland:-

peripheral nerve:5.53

spine:5.55

retina:-

eye:-

artery/aorta:5.93

vein:6.23

lymphnode:6.83

peripheral blood:-

spleen:7.07

thymus:6.05

bone marrow:5.64

adipose:5.90

bone:-

skin:5.67

CAGE

cerebrum:1.49

cerebellum:-

brain stem:1.76

corpus callosum/glia:1.74

pineal gland:1.90

peripheral nerve:-

spine:2.41

retina:-

eye:-

artery/aorta:3.47

vein:4.15

lymphnode:4.04

peripheral blood:-

spleen:3.71

thymus:3.27

bone marrow:-

adipose:3.17

bone:-

skin:-

RNA-seq

cerebrum:0.47

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:1.11

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:1.92

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:54.70

placenta:29.10

prostate:45.10

ovary:-

testis:34.60

heart:-

muscle:-

esophagus:-

stomach:21.20

intestine:32.40

colon:67.80

liver/hepato:-

lung:44

bladder:125.60

kidney:10.40

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:8.90

breast:130.10

salivary:-

GeneChip

uterus:5.89

placenta:5.37

prostate:5.80

ovary:5.69

testis:5.21

heart:5.86

muscle:5.64

esophagus:5.72

stomach:6.13

intestine:6.02

colon:6.20

liver/hepato:5.93

lung:7.07

bladder:-

kidney:5.63

pituitary:5.35

thyroid/parathyroid:5.55

adrenal gland:6.09

pancreas:5.71

breast:5.85

salivary:5.94

CAGE

uterus:3.21

placenta:2.92

prostate:3.42

ovary:3.15

testis:2.44

heart:3.33

muscle:2.72

esophagus:2.98

stomach:-

intestine:2.83

colon:3.04

liver/hepato:2.87

lung:3.51

bladder:3.53

kidney:2.62

pituitary:1.51

thyroid/parathyroid:2.55

adrenal gland:-

pancreas:3.13

breast:3.40

salivary:3.24

RNA-seq

uterus:-

placenta:-

prostate:1.51

ovary:1.77

testis:0.95

heart:0.00

muscle:2.42

esophagus:-

stomach:-

intestine:-

colon:2.14

liver/hepato:0.00

lung:2.98

bladder:-

kidney:1.05

pituitary:-

thyroid/parathyroid:1.68

adrenal gland:3.49

pancreas:-

breast:1.61

salivary:-

IDs

Refseq ID	NM_001077493
Gene ID	4791
Unigene ID	Hs.73090
Probe set ID	207535_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000077150
GTEx ID	ENSG00000077150

Orthologous Gene

Mouse[2]	NM_001177369, NM_001177370, NM_019408
Rat[2]	NM_001177369, NM_001177370, NM_019408

Chromosomal Region

10q24.32 [104,154,229 - 104,162,281]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR002909	Cell surface receptor IPT/TIG
IPR000488	Death
IPR011029	DEATH-like
IPR014756	Immunoglobulin E-set
IPR000451	NF-kappa-B/Rel/dorsal
IPR008967	p53-like transcription factor, DNA-binding
IPR011539	Rel homology

Gene Ontology (GO ID)

Biological Process

GO:0030198	extracellular matrix organization
GO:0002268	follicular dendritic cell differentiation
GO:0002467	germinal center formation
GO:0045087	innate immune response
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0032481	positive regulation of type I interferon production
GO:0006355	regulation of transcription, DNA-dependent
GO:0048536	spleen development
GO:0034166	toll-like receptor 10 signaling pathway
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0002224	toll-like receptor signaling pathway
GO:0006351	transcription, DNA-dependent

Cellular Component

GO:0033257	Bcl3/NF-kappaB2 complex
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005730	nucleolus
GO:0005654	nucleoplasm
GO:0005634	nucleus

Molecular Function

GO:0003677	DNA binding
GO:0005515	protein binding
GO:0003713	transcription coactivator activity
GO:0003700	transcription factor activity

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function